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  1. Artikel ; Online: Introduction to the ATS Core Curriculum Series, 2017.

    Poston, Jason T

    Annals of the American Thoracic Society

    2017  Band 14, Heft Suppl_2, Seite(n) S149

    Mesh-Begriff(e) Curriculum ; Education, Medical, Graduate/methods ; Humans ; Pulmonary Medicine/education ; Societies, Medical ; United States
    Sprache Englisch
    Erscheinungsdatum 2017-10-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201708-660ED
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  2. Artikel ; Online: Management of Critically Ill Adults With COVID-19.

    Poston, Jason T / Patel, Bhakti K / Davis, Andrew M

    JAMA

    2020  Band 323, Heft 18, Seite(n) 1839–1841

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-03-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.4914
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  3. Artikel ; Online: Sepsis associated acute kidney injury.

    Poston, Jason T / Koyner, Jay L

    BMJ (Clinical research ed.)

    2019  Band 364, Seite(n) k4891

    Abstract: Sepsis is defined as organ dysfunction resulting from the host's deleterious response to infection. One of the most common organs affected is the kidneys, resulting in sepsis associated acute kidney injury (SA-AKI) that contributes to the morbidity and ... ...

    Abstract Sepsis is defined as organ dysfunction resulting from the host's deleterious response to infection. One of the most common organs affected is the kidneys, resulting in sepsis associated acute kidney injury (SA-AKI) that contributes to the morbidity and mortality of sepsis. A growing body of knowledge has illuminated the clinical risk factors, pathobiology, response to treatment, and elements of renal recovery that have advanced our ability to prevent, detect, and treat SA-AKI. Despite these advances, SA-AKI remains an important concern and clinical burden, and further study is needed to reduce the acute and chronic consequences. This review summarizes the relevant evidence, with a focus on the risk factors, early recognition and diagnosis, treatment, and long term consequences of SA-AKI. In addition to literature pertaining to SA-AKI specifically, pertinent sepsis and acute kidney injury literature relevant to SA-AKI was included.
    Mesh-Begriff(e) Acute Kidney Injury/classification ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/epidemiology ; Biomarkers/blood ; Critical Care/standards ; Early Diagnosis ; Humans ; Kidney/injuries ; Kidney/microbiology ; Kidney/pathology ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Practice Guidelines as Topic/standards ; Risk Factors ; Sepsis/complications ; Sepsis/epidemiology ; Sepsis/mortality ; Sepsis/prevention & control
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2019-01-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.k4891
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  5. Artikel ; Online: Management of Critically Ill Adults With COVID-19

    Poston, Jason T. / Patel, Bhakti K. / Davis, Andrew M.

    JAMA ; ISSN 0098-7484

    2020  

    Schlagwörter General Medicine ; covid19
    Sprache Englisch
    Verlag American Medical Association (AMA)
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1001/jama.2020.4914
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Hemoglobin-unchained and causing harm in sepsis?

    Greenberg, Jared A / Poston, Jason T

    Critical care medicine

    2013  Band 41, Heft 3, Seite(n) 919–920

    Mesh-Begriff(e) Acetaminophen/pharmacology ; Analgesics, Non-Narcotic/pharmacology ; Female ; Hemoglobins/metabolism ; Hospital Mortality ; Humans ; Male ; Oxidative Stress/drug effects ; Sepsis/mortality
    Chemische Substanzen Analgesics, Non-Narcotic ; Hemoglobins ; Acetaminophen (362O9ITL9D)
    Sprache Englisch
    Erscheinungsdatum 2013-03
    Erscheinungsland United States
    Dokumenttyp Comment ; Editorial
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0b013e3182770570
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Heterogeneous cardiac sympathetic innervation gradients promote arrhythmogenesis in murine dilated cardiomyopathy.

    Dajani, Al-Hassan J / Liu, Michael B / Olaopa, Michael A / Cao, Lucian / Valenzuela-Ripoll, Carla / Davis, Timothy J / Poston, Megan D / Smith, Elizabeth H / Contreras, Jaime / Pennino, Marissa / Waldmann, Christopher M / Hoover, Donald B / Lee, Jason T / Jay, Patrick Y / Javaheri, Ali / Slavik, Roger / Qu, Zhilin / Ajijola, Olujimi A

    JCI insight

    2023  Band 8, Heft 22

    Abstract: Ventricular arrhythmias (VAs) in heart failure are enhanced by sympathoexcitation. However, radiotracer studies of catecholamine uptake in failing human hearts demonstrate a proclivity for VAs in patients with reduced cardiac sympathetic innervation. We ... ...

    Abstract Ventricular arrhythmias (VAs) in heart failure are enhanced by sympathoexcitation. However, radiotracer studies of catecholamine uptake in failing human hearts demonstrate a proclivity for VAs in patients with reduced cardiac sympathetic innervation. We hypothesized that this counterintuitive finding is explained by heterogeneous loss of sympathetic nerves in the failing heart. In a murine model of dilated cardiomyopathy (DCM), delayed PET imaging of sympathetic nerve density using the catecholamine analog [11C]meta-Hydroxyephedrine demonstrated global hypoinnervation in ventricular myocardium. Although reduced, sympathetic innervation in 2 distinct DCM models invariably exhibited transmural (epicardial to endocardial) gradients, with the endocardium being devoid of sympathetic nerve fibers versus controls. Further, the severity of transmural innervation gradients was correlated with VAs. Transmural innervation gradients were also identified in human left ventricular free wall samples from DCM versus controls. We investigated mechanisms underlying this relationship by in silico studies in 1D, 2D, and 3D models of failing and normal human hearts, finding that arrhythmogenesis increased as heterogeneity in sympathetic innervation worsened. Specifically, both DCM-induced myocyte electrical remodeling and spatially inhomogeneous innervation gradients synergistically worsened arrhythmogenesis. Thus, heterogeneous innervation gradients in DCM promoted arrhythmogenesis. Restoration of homogeneous sympathetic innervation in the failing heart may reduce VAs.
    Mesh-Begriff(e) Humans ; Mice ; Animals ; Cardiomyopathy, Dilated/diagnostic imaging ; Heart ; Myocardium ; Arrhythmias, Cardiac/diagnostic imaging ; Catecholamines
    Chemische Substanzen Catecholamines
    Sprache Englisch
    Erscheinungsdatum 2023-11-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.157956
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  8. Artikel ; Online: Heterogeneous cardiac sympathetic innervation gradients promote arrhythmogenesis in murine dilated cardiomyopathy

    Al-Hassan J. Dajani / Michael B. Liu / Michael A. Olaopa / Lucian Cao / Carla Valenzuela-Ripoll / Timothy J. Davis / Megan D. Poston / Elizabeth H. Smith / Jaime Contreras / Marissa Pennino / Christopher M. Waldmann / Donald B. Hoover / Jason T. Lee / Patrick Y. Jay / Ali Javaheri / Roger Slavik / Zhilin Qu / Olujimi A. Ajijola

    JCI Insight, Vol 8, Iss

    2023  Band 22

    Abstract: Ventricular arrhythmias (VAs) in heart failure are enhanced by sympathoexcitation. However, radiotracer studies of catecholamine uptake in failing human hearts demonstrate a proclivity for VAs in patients with reduced cardiac sympathetic innervation. We ... ...

    Abstract Ventricular arrhythmias (VAs) in heart failure are enhanced by sympathoexcitation. However, radiotracer studies of catecholamine uptake in failing human hearts demonstrate a proclivity for VAs in patients with reduced cardiac sympathetic innervation. We hypothesized that this counterintuitive finding is explained by heterogeneous loss of sympathetic nerves in the failing heart. In a murine model of dilated cardiomyopathy (DCM), delayed PET imaging of sympathetic nerve density using the catecholamine analog [11C]meta-Hydroxyephedrine demonstrated global hypoinnervation in ventricular myocardium. Although reduced, sympathetic innervation in 2 distinct DCM models invariably exhibited transmural (epicardial to endocardial) gradients, with the endocardium being devoid of sympathetic nerve fibers versus controls. Further, the severity of transmural innervation gradients was correlated with VAs. Transmural innervation gradients were also identified in human left ventricular free wall samples from DCM versus controls. We investigated mechanisms underlying this relationship by in silico studies in 1D, 2D, and 3D models of failing and normal human hearts, finding that arrhythmogenesis increased as heterogeneity in sympathetic innervation worsened. Specifically, both DCM-induced myocyte electrical remodeling and spatially inhomogeneous innervation gradients synergistically worsened arrhythmogenesis. Thus, heterogeneous innervation gradients in DCM promoted arrhythmogenesis. Restoration of homogeneous sympathetic innervation in the failing heart may reduce VAs.
    Schlagwörter Cardiology ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag American Society for Clinical investigation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Improving medical and pharmacy student confidence in medication management and attitudes about interprofessional collaboration by utilizing an interprofessional module.

    Kostas, Tia / Thomas, Jiz / Thompson, Katherine / Poston, Jason / Levine, Stacie

    Journal of interprofessional care

    2018  Band 32, Heft 6, Seite(n) 790–793

    Abstract: Adverse drug events are common and often preventable. Educating the interprofessional workforce to appropriately manage medications as part of a team is a priority. An interprofessional medication management module for graduating medical and pharmacy ... ...

    Abstract Adverse drug events are common and often preventable. Educating the interprofessional workforce to appropriately manage medications as part of a team is a priority. An interprofessional medication management module for graduating medical and pharmacy students was developed. The module was case-based and co-led by physicians and pharmacists. Students completed pre- and post-module surveys regarding their attitudes about interprofessional collaboration, confidence in managing medications, and self-reported ability to perform the tasks laid out in the minimum geriatrics competencies as a result of the module. Eighteen medical and 13 pharmacy students participated over a two-year period. There was statistically significant improvement in students' attitudes about interprofessional collaboration with regards to understanding their role and the role of others on the interprofessional team, and about teamwork between medical and pharmacy students. There was also statistically significant improvement in confidence with regards to the 3 medication management competencies after completion of the module. The vast majority of students agreed that the module improved their self-reported ability to manage medications. An interprofessional medication management module is an effective way to improve medical and pharmacy students' attitudes about interprofessional collaboration and confidence in medication management.
    Sprache Englisch
    Erscheinungsdatum 2018-08-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1099758-1
    ISSN 1469-9567 ; 0884-3988 ; 1356-1820
    ISSN (online) 1469-9567
    ISSN 0884-3988 ; 1356-1820
    DOI 10.1080/13561820.2018.1512957
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  10. Artikel ; Online: Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit.

    Patel, Shruti B / Poston, Jason T / Pohlman, Anne / Hall, Jesse B / Kress, John P

    American journal of respiratory and critical care medicine

    2014  Band 189, Heft 6, Seite(n) 658–665

    Abstract: Rationale: Intensive care unit (ICU) delirium is associated with ventilator, ICU, and hospital days; discharge functional status; and mortality. Whether rapidly reversible, sedation-related delirium (delirium that abates shortly after sedative ... ...

    Abstract Rationale: Intensive care unit (ICU) delirium is associated with ventilator, ICU, and hospital days; discharge functional status; and mortality. Whether rapidly reversible, sedation-related delirium (delirium that abates shortly after sedative interruption) occurs with the same frequency and portends the same prognosis as persistent delirium (delirium that persists despite a short period of sedative interruption) is unknown.
    Objectives: To compare rapidly reversible, sedation-related delirium and persistent delirium.
    Methods: This was a prospective cohort study of 102 adult, intubated medical ICU subjects in a tertiary care teaching hospital. Confusion Assessment Method for the ICU evaluation was performed before and after daily interruption of continuous sedation (DIS). Investigators were blinded to each other's assessments and as to whether evaluations were before or after DIS. The primary outcome was proportion of days with no delirium versus rapidly reversible, sedation-related delirium versus persistent delirium. Secondary outcomes were ventilator, ICU, and hospital days; discharge disposition; and 1-year mortality.
    Measurements and main results: The median proportion of ICU days with delirium was 0.57 before versus 0.50 after DIS (P < 0.001). The Confusion Assessment Method for the ICU indicated patients are 10.5 times more likely to have delirium before DIS versus after (P < 0.001). Rapidly reversible, sedation-related delirium showed fewer ventilator (P < 0.001), ICU (P = 0.001), and hospital days (P < 0.001) than persistent delirium. Subjects with no delirium and rapidly reversible, sedation-related delirium were more likely to be discharged home (P < 0.001). Patients with persistent delirium had increased 1-year mortality versus those with no delirium and rapidly reversible, sedation-related delirium (P < 0.001).
    Conclusions: Rapidly reversible, sedation-related delirium does not signify the same poor prognosis as persistent delirium. Degree of sedation should be considered in delirium assessments. Coordinating delirium assessments with daily sedative interruption will improve such assessments' ability to prognosticate ICU delirium outcomes. Clinical trial registered with www.clinicaltrials.gov (NCT 00919698).
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Conscious Sedation/adverse effects ; Conscious Sedation/methods ; Critical Care/methods ; Delirium/chemically induced ; Delirium/diagnosis ; Delirium/mortality ; Delirium/therapy ; Female ; Fentanyl/adverse effects ; Follow-Up Studies ; Humans ; Hypnotics and Sedatives/adverse effects ; Intensive Care Units ; Length of Stay/statistics & numerical data ; Logistic Models ; Male ; Middle Aged ; Outcome Assessment (Health Care) ; Prognosis ; Propofol/adverse effects ; Proportional Hazards Models ; Prospective Studies ; Respiration, Artificial/statistics & numerical data ; Single-Blind Method ; Young Adult
    Chemische Substanzen Hypnotics and Sedatives ; Fentanyl (UF599785JZ) ; Propofol (YI7VU623SF)
    Sprache Englisch
    Erscheinungsdatum 2014-03-15
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201310-1815OC
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