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  1. Artikel: An Online Version of Physical Exercise with Musical Accompaniment Might Facilitate Participation by Subjects Who Cannot Participate in Person: A Questionnaire-Based Study.

    Satoh, Masayuki / Tabei, Ken-Ichi / Ogawa, Jun-Ichi / Abe, Makiko / Kamikawa, Chiaki / Ota, Yoshinori

    Dementia and geriatric cognitive disorders extra

    2023  Band 13, Heft 1, Seite(n) 10–17

    Abstract: Introduction: Due to the ongoing outbreak of the coronavirus disease 2019 (COVID-19), it is currently difficult to conduct in-person exercise classes. We thus started the program of an online physical exercise with musical accompaniment. Several ... ...

    Abstract Introduction: Due to the ongoing outbreak of the coronavirus disease 2019 (COVID-19), it is currently difficult to conduct in-person exercise classes. We thus started the program of an online physical exercise with musical accompaniment. Several interesting differences were found in the characteristics of the online participants compared with our previous in-person interventions.
    Participants and methods: The total number of subjects was 88 (71.2 ± 4.9 years old; male 42, female 46). The questionnaire included the attributes of the participants, the perceived advantages of the exercise classes, and the presence or absence of noticeable changes in cognitive and physical function after participating in the classes.
    Results: The personal computers used to attend the online classes were operated by the participants themselves. About 42% of the participants felt that their sense of day of the week and volition were improved by attending the exercise classes for 3 months. The most frequent answer to the reason for participation was because it was free (81.8%). The second most frequent answer was because the classes were held online (75.0%). Almost half of the participants answered that they would not participate if it was held in person because of the risk of COVID-19 infection (75.0%) and the difficulty getting to the site where the exercise classes were held (59.1%).
    Conclusion: Online physical exercise with musical accompaniment improved the perceived orientation, volition, activity, exercise habits, and health condition in 30-40% of the participants and also stimulated greater participation by males compared to classes held in person.
    Sprache Englisch
    Erscheinungsdatum 2023-05-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2621464-7
    ISSN 1664-5464
    ISSN 1664-5464
    DOI 10.1159/000529192
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Online physical exercise program with music improves working memory.

    Tabei, Ken-Ichi / Ogawa, Jun-Ichi / Kamikawa, Chiaki / Abe, Makiko / Ota, Yoshinori / Satoh, Masayuki

    Frontiers in aging neuroscience

    2023  Band 15, Seite(n) 1146060

    Abstract: Objective: The spread of coronavirus disease (COVID-19) has limited the implementation of face-to-face non-pharmacological treatment for the prevention of dementia. As a result, online non-pharmacological treatment has become increasingly important. In ... ...

    Abstract Objective: The spread of coronavirus disease (COVID-19) has limited the implementation of face-to-face non-pharmacological treatment for the prevention of dementia. As a result, online non-pharmacological treatment has become increasingly important. In this study, we used an online conferencing system to implement an online version of a physical exercise program with music, and examined its effect on cognitive function.
    Methods: The participants were 114 healthy older adults [63 men and 51 women; mean age of 70.7 years (standard deviation = 4.6)]. Seventy-five participants were allocated to the physical exercise with music group (60 min, once a week, total 20 sessions), while the remaining 39 participants were assigned to the control group, and only underwent the examinations. In the physical exercise with music group, we performed neuropsychological examinations and brain tests both before and after the exercise program. Neuropsychological tests included the Mini-Mental State Examination, Raven's Colored Progressive Matrices (RCPM), the Rivermead Behavioral Memory Test, graphic imitation, word fluency (WF) (animal names and initial sounds), and the Trail Making Test-A/B. As an assessment of brain function, we developed an online examination of subtle cognitive decline, including tests of number and word memory, spatial grasp, the N-back task, and change inference.
    Results: In the N-back task, the physical exercise with music group improved significantly relative to the control group (
    Discussion: The present findings suggest that the online version of the physical exercise with music program improved working memory, which mainly involves the frontal lobe.
    Sprache Englisch
    Erscheinungsdatum 2023-07-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1146060
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: [Molecular Pathogenesis of Nasu-Hakola Disease Brain Lesions].

    Satoh, Jun-Ichi

    Brain and nerve = Shinkei kenkyu no shinpo

    2016  Band 68, Heft 5, Seite(n) 543–550

    Abstract: Nasu-Hakola disease (NHD) is a rare intractable autosomal recessive disorder, characterized by pathological bone fractures and progressive dementia owing to multifocal bone cysts and leukoencephalopathy, caused by various genetic mutations of either ... ...

    Abstract Nasu-Hakola disease (NHD) is a rare intractable autosomal recessive disorder, characterized by pathological bone fractures and progressive dementia owing to multifocal bone cysts and leukoencephalopathy, caused by various genetic mutations of either DAP12 or TREM2. Loss-of-function of TREM2-DAP12, constituting a signaling complex on osteoclasts and microglia, plays a central role in the pathogenesis of NHD. Recently, NHD has been recognized as the disease entity designated "microgliopathy". However, at present, TREM2-specific ligands in microglia and the precise molecular mechanism underlying leukoencephalopathy remain to be investigated in order to establish an effective molecular targeted therapy for NHD.
    Mesh-Begriff(e) Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Brain/metabolism ; Humans ; Lipodystrophy/genetics ; Lipodystrophy/metabolism ; Lipodystrophy/pathology ; Lipodystrophy/physiopathology ; Membrane Glycoproteins/metabolism ; Membrane Proteins/metabolism ; Osteochondrodysplasias/genetics ; Osteochondrodysplasias/metabolism ; Osteochondrodysplasias/pathology ; Osteochondrodysplasias/physiopathology ; Protein Binding ; Receptors, Immunologic/metabolism ; Signal Transduction ; Subacute Sclerosing Panencephalitis/genetics ; Subacute Sclerosing Panencephalitis/metabolism ; Subacute Sclerosing Panencephalitis/pathology ; Subacute Sclerosing Panencephalitis/physiopathology
    Chemische Substanzen Adaptor Proteins, Signal Transducing ; Membrane Glycoproteins ; Membrane Proteins ; Receptors, Immunologic ; TREM2 protein, human ; TYROBP protein, human
    Sprache Japanisch
    Erscheinungsdatum 2016-05
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416200435
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Molecular network of ChIP-Seq-based NF-κB p65 target genes involves diverse immune functions relevant to the immunopathogenesis of multiple sclerosis.

    Satoh, Jun-Ichi

    Multiple sclerosis and related disorders

    2014  Band 3, Heft 1, Seite(n) 94–106

    Abstract: Background: The transcription factor nuclear factor-kappa B (NF-κB) acts as a central regulator of immune response, stress response, cell proliferation, and apoptosis. Aberrant regulation of NF-κB function triggers development of cancers, metabolic ... ...

    Abstract Background: The transcription factor nuclear factor-kappa B (NF-κB) acts as a central regulator of immune response, stress response, cell proliferation, and apoptosis. Aberrant regulation of NF-κB function triggers development of cancers, metabolic diseases, and autoimmune diseases. We attempted to characterize a global picture of the NF-κB target gene network relevant to the immunopathogenesis of multiple sclerosis (MS).
    Methods: We identified the comprehensive set of 918 NF-κB p65 binding sites on protein-coding genes from chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) dataset of TNFα-stimulated human B lymphoblastoid cells. The molecular network was studied by a battery of pathway analysis tools of bioinformatics.
    Results: The GenomeJack genome viewer showed that NF-κB p65 binding sites were accumulated in promoter (35.5%) and intronic (54.9%) regions with an existence of the NF-κB consensus sequence motif. A set of 52 genes (5.7%) corresponded to known NF-κB targets by database search. KEGG, PANTHER, and Ingenuity Pathways Analysis (IPA) revealed that the NF-κB p65 target gene network is linked to regulation of immune functions and oncogenesis, including B cell receptor signaling, T cell activation pathway, Toll-like receptor signaling, and apoptosis signaling, and molecular mechanisms of cancers. KeyMolnet indicated an involvement of the complex crosstalk among core transcription factors in the NF-κB p65 target gene network. Furthermore, the set of NF-κB p65 target genes included 10 genes among 98 MS risk alleles and 49 molecules among 709 MS brain lesion-specific proteins.
    Conclusions: These results suggest that aberrant regulation of NF-κB-mediated gene expression, by inducing dysfunction of diverse immune functions, is closely associated with development and progression of MS.
    Sprache Englisch
    Erscheinungsdatum 2014-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2211-0356
    ISSN (online) 2211-0356
    DOI 10.1016/j.msard.2013.04.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Nonthermal acceleration of protein hydration by sub-terahertz irradiation

    Jun-ichi Sugiyama / Yuji Tokunaga / Mafumi Hishida / Masahito Tanaka / Koh Takeuchi / Daisuke Satoh / Masahiko Imashimizu

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 13

    Abstract: Abstract The collective intermolecular dynamics of protein and water molecules, which overlap in the sub-terahertz (THz) frequency region, are relevant for expressing protein functions but remain largely unknown. This study used dielectric relaxation (DR) ...

    Abstract Abstract The collective intermolecular dynamics of protein and water molecules, which overlap in the sub-terahertz (THz) frequency region, are relevant for expressing protein functions but remain largely unknown. This study used dielectric relaxation (DR) measurements to investigate how externally applied sub-THz electromagnetic fields perturb the rapid collective dynamics and influence the considerably slower chemical processes in protein–water systems. We analyzed an aqueous lysozyme solution, whose hydration is not thermally equilibrated. By detecting time-lapse differences in microwave DR, we demonstrated that sub-THz irradiation gradually decreases the dielectric permittivity of the lysozyme solution by reducing the orientational polarization of water molecules. Comprehensive analysis combining THz and nuclear magnetic resonance spectroscopies suggested that the gradual decrease in the dielectric permittivity is not induced by heating but is due to a slow shift toward the hydrophobic hydration structure in lysozyme. Our findings can be used to investigate hydration-mediated protein functions based on sub-THz irradiation.
    Schlagwörter Science ; Q
    Thema/Rubrik (Code) 541
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Nonthermal acceleration of protein hydration by sub-terahertz irradiation.

    Sugiyama, Jun-Ichi / Tokunaga, Yuji / Hishida, Mafumi / Tanaka, Masahito / Takeuchi, Koh / Satoh, Daisuke / Imashimizu, Masahiko

    Nature communications

    2023  Band 14, Heft 1, Seite(n) 2825

    Abstract: The collective intermolecular dynamics of protein and water molecules, which overlap in the sub-terahertz (THz) frequency region, are relevant for expressing protein functions but remain largely unknown. This study used dielectric relaxation (DR) ... ...

    Abstract The collective intermolecular dynamics of protein and water molecules, which overlap in the sub-terahertz (THz) frequency region, are relevant for expressing protein functions but remain largely unknown. This study used dielectric relaxation (DR) measurements to investigate how externally applied sub-THz electromagnetic fields perturb the rapid collective dynamics and influence the considerably slower chemical processes in protein-water systems. We analyzed an aqueous lysozyme solution, whose hydration is not thermally equilibrated. By detecting time-lapse differences in microwave DR, we demonstrated that sub-THz irradiation gradually decreases the dielectric permittivity of the lysozyme solution by reducing the orientational polarization of water molecules. Comprehensive analysis combining THz and nuclear magnetic resonance spectroscopies suggested that the gradual decrease in the dielectric permittivity is not induced by heating but is due to a slow shift toward the hydrophobic hydration structure in lysozyme. Our findings can be used to investigate hydration-mediated protein functions based on sub-THz irradiation.
    Mesh-Begriff(e) Muramidase/chemistry ; Proteins/chemistry ; Water/chemistry ; Chemical Phenomena
    Chemische Substanzen Muramidase (EC 3.2.1.17) ; Proteins ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2023-05-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38462-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Molecular network analysis of human microRNA targetome: from cancers to Alzheimer's disease.

    Satoh, Jun-Ichi

    BioData mining

    2012  Band 5, Heft 1, Seite(n) 17

    Abstract: MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs, mediate posttranscriptional regulation of protein-coding genes by binding chiefly to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or ... ...

    Abstract MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs, mediate posttranscriptional regulation of protein-coding genes by binding chiefly to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or degradation. A single miRNA concurrently downregulates hundreds of target mRNAs designated "targetome", and thereby fine-tunes gene expression involved in diverse cellular functions, such as development, differentiation, proliferation, apoptosis and metabolism. Recently, we characterized the molecular network of the whole human miRNA targetome by using bioinformatics tools for analyzing molecular interactions on the comprehensive knowledgebase. We found that the miRNA targetome regulated by an individual miRNA generally constitutes the biological network of functionally-associated molecules in human cells, closely linked to pathological events involved in cancers and neurodegenerative diseases. We also identified a collaborative regulation of gene expression by transcription factors and miRNAs in cancer-associated miRNA targetome networks. This review focuses on the workflow of molecular network analysis of miRNA targetome in silico. We applied the workflow to two representative datasets, composed of miRNA expression profiling of adult T cell leukemia (ATL) and Alzheimer's disease (AD), retrieved from Gene Expression Omnibus (GEO) repository. The results supported the view that miRNAs act as a central regulator of both oncogenesis and neurodegeneration.
    Sprache Englisch
    Erscheinungsdatum 2012-10-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2438773-3
    ISSN 1756-0381 ; 1756-0381
    ISSN (online) 1756-0381
    ISSN 1756-0381
    DOI 10.1186/1756-0381-5-17
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Molecular network of microRNA targets in Alzheimer's disease brains.

    Satoh, Jun-ichi

    Experimental neurology

    2012  Band 235, Heft 2, Seite(n) 436–446

    Abstract: MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of target mRNAs. The vast majority of presently identified miRNAs are expressed in the brain where they fine-tune the expression of a wide range of target ... ...

    Abstract MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of target mRNAs. The vast majority of presently identified miRNAs are expressed in the brain where they fine-tune the expression of a wide range of target molecules essential for neuronal and glial development, differentiation, proliferation, apoptosis and metabolism. Aberrant expression and dysfunction of brain-enriched miRNAs induce development of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Because a single miRNA concurrently downregulates hundreds of target mRNAs, the set of miRNA target genes coregulated by an individual miRNA generally constitutes the biologically integrated network of functionally associated molecules. Recent advances in systems biology enable us to characterize the global molecular network of experimentally validated targets for individual miRNAs by using pathway analysis tools of bioinformatics endowed with comprehensive knowledgebase. This review is conducted to summarize accumulating studies focused on aberrant miRNA expression in AD brains, and to propose the systems biological view that abnormal regulation of cell cycle progression as a result of deregulation of miRNA target networks plays a central role in the pathogenesis of AD.
    Mesh-Begriff(e) Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/therapy ; Animals ; Brain/metabolism ; Brain/pathology ; Brain Chemistry/genetics ; Gene Regulatory Networks/genetics ; Gene Targeting/methods ; Humans ; MicroRNAs/biosynthesis ; MicroRNAs/genetics
    Chemische Substanzen MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2012-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2011.09.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Reactive astrocytes express Aggregatin (

    Satoh, Jun-Ichi / Kino, Yoshihiro / Yanaizu, Motoaki / Ishida, Tsuyoshi / Saito, Yuko

    Intractable & rare diseases research

    2020  Band 9, Heft 4, Seite(n) 217–221

    Abstract: By combining genomic data and brain imaging data, a recent study has identified a novel gene ... ...

    Abstract By combining genomic data and brain imaging data, a recent study has identified a novel gene named
    Sprache Englisch
    Erscheinungsdatum 2020-10-28
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2672570-8
    ISSN 2186-361X ; 2186-3644
    ISSN (online) 2186-361X
    ISSN 2186-3644
    DOI 10.5582/irdr.2020.03080
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains.

    Satoh, Jun-ichi

    Journal of pharmacological sciences

    2010  Band 114, Heft 3, Seite(n) 269–275

    Abstract: MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are ...

    Abstract MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled manner. They play a key role in neuronal development, differentiation, and synaptic plasticity. However, at present, the pathological implications of deregulated miRNA expression in neurodegenerative diseases remain largely unknown. This review will briefly summarize recent studies that focus attention on aberrant miRNA expression in Alzheimer's disease brains.
    Mesh-Begriff(e) Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Brain/metabolism ; Gene Expression Regulation/physiology ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurons/metabolism ; Neurons/physiology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Chemische Substanzen MIRN29a microRNA, human ; Membrane Proteins ; MicroRNAs ; NAV3 protein, human ; Nerve Tissue Proteins ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2010-10-09
    Erscheinungsland Japan
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2104264-0
    ISSN 1347-8648 ; 1347-8613
    ISSN (online) 1347-8648
    ISSN 1347-8613
    DOI 10.1254/jphs.10r11fm
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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