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  1. Artikel: Hilfer-Katugampola fractional stochastic differential inclusions with Clarke sub-differential.

    Mshary, Noorah / Ahmed, Hamdy M / Ghanem, Ahmed S / Sayed Ahmed, A M

    Heliyon

    2024  Band 10, Heft 8, Seite(n) e29667

    Abstract: The objective of this paper is to investigate the existence of mild solutions and optimal controls for a class of stochastic Hilfer-Katugampola fractional differential inclusions (SHKFDIs) with non-instantaneous impulsive (NIIs) that is strengthened by ... ...

    Abstract The objective of this paper is to investigate the existence of mild solutions and optimal controls for a class of stochastic Hilfer-Katugampola fractional differential inclusions (SHKFDIs) with non-instantaneous impulsive (NIIs) that is strengthened by Brownian motion (BM) and the Clarke sub-differential. First, we establish a new set of sufficient conditions for the existence of mild solutions of the aforementioned fractional systems by using stochastic analysis, the Clarke sub-differential's characteristics, and the multi-valued fixed point theorem. Subsequently, by employing Balder's theorem, the existence of optimal control pairs for the considered system is investigated. Eventually, an example is provided to validate the obtained results.
    Sprache Englisch
    Erscheinungsdatum 2024-04-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29667
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Effect of bempedoic acid on mortality and cardiovascular events in primary and secondary prevention: A post-hoc analysis of the CLEAR-outcomes trial.

    Sayed, Ahmed / Brophy, James M

    International journal of cardiology

    2024  Band 406, Seite(n) 132074

    Abstract: Background: The effects of bempedoic acid on mortality in the secondary prevention setting have not been examined.: Methods: We used data from the overall and primary prevention reports of CLEAR - Outcomes to reconstruct data for the secondary ... ...

    Abstract Background: The effects of bempedoic acid on mortality in the secondary prevention setting have not been examined.
    Methods: We used data from the overall and primary prevention reports of CLEAR - Outcomes to reconstruct data for the secondary prevention population. A Bayesian analyses was employed to calculate the posterior probability of benefit or harm for the outcomes of all-cause mortality, cardiovascular mortality, and major adverse cardiovascular events (MACE). Relative effect sizes are presented as risk ratios (RR) with 95% credible intervals (CrI), which represent the intervals that true effect sizes are expected to fall in with 95% probability, given the priors and model.
    Results: In primary prevention, the posterior probability of bempedoic acid decreasing all-cause and cardiovascular mortality was 99.4% (RR: 0.70; 95% CrI: 0.51 to 0.92) and 99.7% (RR: 0.58; 95% CrI: 0.38 to 0.86) respectively. In secondary prevention, the posterior probability of bempedoic acid increasing all-cause and cardiovascular mortality was 96.6% (RR: 1.15; 95% CrI: 0.99 to 1.33) and 97.2% (RR: 1.21; 95% CrI: 1.00 to 1.45) respectively. The probability of bemepdoic acid reducing MACE in the primary and secondary prevention settings was 99.9% (RR: 0.70; 95% CrI: 0.54 to 0.88) and 95.8% (RR: 0.92; 95% CrI: 0.84 to 1.01) respectively.
    Conclusion: In contrast to its effect in the primary prevention subgroup of CLEAR - Outcomes, bempedoic acid resulted in a more modest MACE reduction and a potential increase in mortality in the secondary prevention subgroup. Whether these findings represent true treatment effect heterogeneity or the play of chance requires further evidence.
    Sprache Englisch
    Erscheinungsdatum 2024-04-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2024.132074
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch ; Audio / Video ; Dissertation / Habilitation: CT-Perfusion und Dual-energy-CT von Tumoren in der Hals-Nasen-Ohren Region

    Tawfik Mohamed Sayed Ahmed, Ahmed Mohamed

    2011  

    Verfasserangabe vorgelegt von Ahmed Mohamed Tawfik Mohamed Sayed Ahmed
    Sprache Englisch
    Umfang III, 104 S., Ill., graph. Darst. ; 1 CD-ROM, 12 cm
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Audio / Video ; Dissertation / Habilitation
    Dissertation / Habilitation Frankfurt (Main), Univ., Diss., 2011
    HBZ-ID HT016929833
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Artikel ; Online: Determination of antihistaminic drugs alcaftadine and olopatadine hydrochloride via ion-pairing with eosin Y as a spectrofluorimetric and spectrophotometric probe: application to dosage forms.

    Derayea, Sayed M / Badr El-Din, Khalid M / Ahmed, Ahmed S / Khorshed, Ahmed A / Oraby, Mohamed

    BMC chemistry

    2024  Band 18, Heft 1, Seite(n) 40

    Abstract: ... of Alcaftadine or Olopatadine hydrochloride on the intrinsic fluorescence of eosin Y in a 0.1 M acetate buffer ...

    Abstract Four sensitive and fast analytical approaches relied on ion pairing with eosin Y were built up and evaluated using spectroscopy for determination of Alcaftadine and Olopatadine hydrochloride with high sensitivity and selectivity. Two spectrofluorimetric techniques were employed to observe the quenching effect of Alcaftadine or Olopatadine hydrochloride on the intrinsic fluorescence of eosin Y in a 0.1 M acetate buffer solution at pH 3.8 and 3.3 for Alcaftadine and Olopatadine hydrochloride, respectively. Those methods are considered the first spectrofluorimetric methods for Alcaftadine and Olopatadine hydrochloride assay. The fluorescence quenching effect was linear with concentration ranging from 150 to 2000 and 200 to 2000 ng mL
    Sprache Englisch
    Erscheinungsdatum 2024-02-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-024-01137-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Development of a green synchronous spectrofluorimetric technique for simultaneous determination of Montelukast sodium and Bilastine in pharmaceutical formulations.

    Derayea, Sayed M / Badr El-Din, Khalid M / Ahmed, Ahmed S / Khorshed, Ahmed A / Oraby, Mohamed

    BMC chemistry

    2024  Band 18, Heft 1, Seite(n) 18

    Abstract: For the treatment of rhinitis and asthma, a combination of Montelukast sodium and Bilastine has just been approved. Based on the first derivative of synchronous fluorescence, the current work developed a green, highly accurate, sensitive, and selective ... ...

    Abstract For the treatment of rhinitis and asthma, a combination of Montelukast sodium and Bilastine has just been approved. Based on the first derivative of synchronous fluorescence, the current work developed a green, highly accurate, sensitive, and selective spectroscopic approach for estimating Montelukast sodium and Bilastine in pharmaceutical dosage form without previous separation. The selected technique focuses on measuring the synchronized fluorescence of the studied medications at a fixed wavelength range (Δλ) = 110 nm, and using the amplitude of the first derivative's peak at 381 and 324 nm, for quantitative estimation of Montelukast sodium and Bilastine, respectively. The impacts of different factors on the referred drugs' synchronized fluorescence intensity were investigated and adjusted. The calibration plots for were found to be linear over concentration ranges of 50-2000 ng mL
    Sprache Englisch
    Erscheinungsdatum 2024-01-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-024-01116-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Imaging of Bifid Fourth Rib Presenting as a Chest Wall Mass in an Infant.

    Garg, Pankaj / El-Sayed Ahmed, Magdy M

    Texas Heart Institute journal

    2023  Band 50, Heft 1

    Mesh-Begriff(e) Humans ; Infant ; Thoracic Wall/diagnostic imaging ; Ribs/diagnostic imaging ; Ribs/surgery ; Diagnostic Imaging
    Sprache Englisch
    Erscheinungsdatum 2023-02-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 604761-0
    ISSN 1526-6702 ; 0730-2347
    ISSN (online) 1526-6702
    ISSN 0730-2347
    DOI 10.14503/THIJ-22-7975
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Metabolic profiling, antimicrobial, anticancer, and in vitro and in silico immunomodulatory investigation of Aspergillus niger OR730979 isolated from the Western Desert, Egypt.

    Baz, Amira M / Elwy, Esmat / Ahmed, Wafaa A / El-Sayed, Heba

    International microbiology : the official journal of the Spanish Society for Microbiology

    2024  

    Abstract: Ten fungal species were isolated from soil in the Western Desert and Wadi El-Natron in Egypt. All fungal isolates were morphologically recognized down to the species level. Methanol extracts of fungal mycelia and ethyl acetate extracts of culture ... ...

    Abstract Ten fungal species were isolated from soil in the Western Desert and Wadi El-Natron in Egypt. All fungal isolates were morphologically recognized down to the species level. Methanol extracts of fungal mycelia and ethyl acetate extracts of culture filtrate from the isolated fungi were evaluated for antimicrobial activity against six pathogenic bacteria and one pathogenic yeast (Candida albicans ATCC20231). Only ethyl acetate extracts of Fusarium circinatum, Aspergillus niger, and Aspergillus terreus culture filtrates showed significant antimicrobial activity against the majority of the investigated pathogens. The culture filtrate extract of Aspergillus niger exhibited notable cytotoxicity towards the breast cancer (MCF-7) cell line, with the lowest detected IC
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1454951-7
    ISSN 1618-1905 ; 1139-6709
    ISSN (online) 1618-1905
    ISSN 1139-6709
    DOI 10.1007/s10123-024-00503-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Design, synthesis, structure elucidation, antimicrobial, molecular docking, and SAR studies of novel urea derivatives bearing tricyclic aromatic hydrocarbon rings.

    Sroor, Farid M / El-Sayed, Ahmed F / Abdelraof, Mohamed

    Archiv der Pharmazie

    2024  , Seite(n) e2300738

    Abstract: The targeted compounds were prepared using both (9H-fluoren-9-ylidene)hydrazine (1) and 10H-phenothiazine (2) as starting materials. The treatment of 1 or 2 with different isocyanates afforded the title compounds 7a-d, 8a, and 8b in excellent yield. All ... ...

    Abstract The targeted compounds were prepared using both (9H-fluoren-9-ylidene)hydrazine (1) and 10H-phenothiazine (2) as starting materials. The treatment of 1 or 2 with different isocyanates afforded the title compounds 7a-d, 8a, and 8b in excellent yield. All compounds were characterized and ascertained by infrared, nuclear magnetic resonance, and elemental analyses as well as single-crystal X-ray diffraction. The antimicrobial efficiency of all was tested in vitro, and a noticeable inhibition activity against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans was obtained by compounds 7a, 7b, 8a, and 8b. Moreover, the biofilm mechanism activity was strongly inhibited by compounds 7b and 8b for all bacterial pathogens, with a percentage ratio of more than 55%. The findings from the molecular docking simulation revealed that compounds 7a, 7b, 8a, and 8b exhibited favorable binding energies and interacted effectively with the active sites of sterol 14-demethylase, dihydropteroate synthase, gyrase B, LasR (major transcriptional activator of P. aeruginosa), and carbapenemase for C. albicans, S. aureus, B. subtills, K. pneumoniae, and P. aeruginosa, respectively. These results suggest that the compounds have the potential to inhibit the activity of these enzymes and demonstrate promising antimicrobial properties. Moreover, the in silico evaluation of drug likeness and absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles for compounds 7a, 7b, 8a, and 8b demonstrated their compatibility with Lipinski's, Ghose's, Veber's, Muegge's, and Egan's rules. These findings suggest that these compounds possess favorable physicochemical properties, making them promising candidates for continued drug development efforts.
    Sprache Englisch
    Erscheinungsdatum 2024-03-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.202300738
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Value of Serum Asymmetric Dimethylarginine (ADMA) As a Novel Biomarker for Uveitis in Behçet's Disease.

    Sayed, Omima Ahmed / Abdel-Magied, Rasha Ali / Ahmed Abu Elela, Mostafa / Safwat, Abdallah Mm / Abdel-Nasser, Ahmed M

    Ocular immunology and inflammation

    2024  , Seite(n) 1–7

    Abstract: Purpose: To evaluate the serum asymmetric dimethylarginine (ADMA) level as a biomarker for uveitis in Behçet's Disease (BD).: Methods: In this cross-sectional study, two groups of BD patients were examined: 33 with uveitis and 27 without uveitis. All ...

    Abstract Purpose: To evaluate the serum asymmetric dimethylarginine (ADMA) level as a biomarker for uveitis in Behçet's Disease (BD).
    Methods: In this cross-sectional study, two groups of BD patients were examined: 33 with uveitis and 27 without uveitis. All patients were clinically evaluated, with disease activity measured by Behçet's Disease Current Activity Form (BDCAF) score. They also underwent thorough ophthalmic evaluation, and routine laboratory investigations, including serum ADMA.
    Results: Patients with BD who experienced active or inactive uveitis had higher levels of serum ADMA compared to those without uveitis. Anterior (ρ = 0.34,
    Conclusion: Serum ADMA level can serve as a novel biomarker of uveitis in BD and its severity with good diagnostic accuracy, regardless of its site or activity.
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2024.2342378
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Valorization of edible films based on chitosan/hydroxyethyl cellulose/olive leaf extract and TiO

    El-Sayed, Samah M / El-Sayed, Hoda S / Hashim, Ayat F / Youssef, Ahmed M

    International journal of biological macromolecules

    2024  Band 268, Heft Pt 1, Seite(n) 131727

    Abstract: Biodegradable edible films for sour cream packaging were developed based on chitosan (CS), hydroxyethyl cellulose (HEC), Olive leaf extract (OE), and titanium dioxide nanoparticles ( ... ...

    Abstract Biodegradable edible films for sour cream packaging were developed based on chitosan (CS), hydroxyethyl cellulose (HEC), Olive leaf extract (OE), and titanium dioxide nanoparticles (TiO
    Sprache Englisch
    Erscheinungsdatum 2024-04-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131727
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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