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  1. Artikel ; Online: Prevalence of massively diluted bone marrow cell samples aspirated from patients with myelodysplastic syndromes (MDS) or suspected of MDS: A retrospective analysis of nationwide samples in Japan.

    Ogata, Kiyoyuki / Mochimaru, Yuto / Kasai, Nana / Sei, Kazuma / Kawahara, Naoya / Ogata, Mika / Yamamoto, Yumi

    British journal of haematology

    2024  

    Abstract: Bone marrow (BM) examination is a key element in the diagnosis and prognostic grading of myelodysplastic syndromes (MDSs), and obtaining adequate BM cell samples is critical for accurate test results. Massive haemodilution of aspirated BM samples is a ... ...

    Abstract Bone marrow (BM) examination is a key element in the diagnosis and prognostic grading of myelodysplastic syndromes (MDSs), and obtaining adequate BM cell samples is critical for accurate test results. Massive haemodilution of aspirated BM samples is a well-known problem; however, its incidence in patients with MDS has not been well studied. We report the first study to examine the incidence of massive haemodilution in nationwide BM samples aspirated from patients diagnosed with or suspected of MDS in Japan. Among 283 cases available for analysis, BM smears from 92 cases (32.5%) were hypospicular (massively haemodiluted) and, particularly, no BM particles were observed in 52 cases (18.4%). Regarding hypospicular cases, we examined how the doctors in charge interpreted the BM smears of their patients. In only 19 of 92 cases (20.7%), doctors realised that the BM smears were haemodiluted. Furthermore, the BM biopsy, which can help diagnose hypospicular cases, was oftentimes not performed when the haemodilution was overlooked by doctors (not performed in 50 of 73 such cases). These real-world data highlight that not only researchers who are working to improve diagnostic tests but also clinicians who perform and use diagnostic tests must realise this common and potentially critical problem.
    Sprache Englisch
    Erscheinungsdatum 2024-04-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19447
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: WT1 Expression in Patients with Myelodysplastic Syndromes: A Variety of Possibilities in Future Clinical Practice.

    Ogata, Kiyoyuki

    Acta haematologica

    2017  Band 137, Heft 1, Seite(n) 30–31

    Mesh-Begriff(e) Biomarkers/metabolism ; Bone Marrow Cells/immunology ; Bone Marrow Cells/pathology ; Gene Expression ; Humans ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/immunology ; Myelodysplastic Syndromes/pathology ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; WT1 Proteins/genetics ; WT1 Proteins/immunology
    Chemische Substanzen Biomarkers ; RNA, Messenger ; WT1 Proteins ; WT1 protein, human
    Sprache Englisch
    Erscheinungsdatum 2017
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 80008-9
    ISSN 1421-9662 ; 0001-5792
    ISSN (online) 1421-9662
    ISSN 0001-5792
    DOI 10.1159/000449363
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Myeloblasts transition to megakaryoblastic immunophenotypes over time in some patients with myelodysplastic syndromes.

    Ogata, Kiyoyuki / Mochimaru, Yuto / Sei, Kazuma / Kawahara, Naoya / Ogata, Mika / Yamamoto, Yumi

    PloS one

    2023  Band 18, Heft 9, Seite(n) e0291662

    Abstract: Objectives: In myelodysplastic syndromes (MDS), neoplastic myeloblast (CD34+CD13+CD33+ cells) numbers often increase over time, leading to secondary acute myeloid leukemia (AML). In recent studies, blasts in some MDS patients have been found to express ... ...

    Abstract Objectives: In myelodysplastic syndromes (MDS), neoplastic myeloblast (CD34+CD13+CD33+ cells) numbers often increase over time, leading to secondary acute myeloid leukemia (AML). In recent studies, blasts in some MDS patients have been found to express a megakaryocyte-lineage molecule, CD41, and such patients show extremely poor prognosis. This is the first study to evaluate whether myeloblasts transition to CD41+ blasts over time and to investigate the detailed immunophenotypic features of CD41+ blasts in MDS.
    Methods: We performed a retrospective cohort study, in which time-dependent changes in blast immunophenotypes were analyzed using multidimensional flow cytometry (MDF) in 74 patients with MDS and AML (which progressed from MDS).
    Results: CD41+ blasts (at least 20% of CD34+ blasts expressing CD41) were detected in 12 patients. In five of these 12 patients, blasts were CD41+ from the first MDF analysis. In the other seven patients, myeloblasts (CD34+CD33+CD41- cells) transitioned to megakaryoblasts (CD34+CD41+ cells) over time, which was often accompanied by disease progression (including leukemic transformation). These CD41+ patients were more frequently observed among patients with monosomal and complex karyotypes. CD41+ blasts were negative for the erythroid antigen, CD235a, and positive for CD33 in all cases, but CD33 expression levels were lower in three cases when compared with CD34+CD41- blasts. Among the five CD41+ patients who underwent extensive immunophenotyping, CD41+ blasts all expressed CD61, but two cases had reduced CD42b expression, three had reduced/absent CD13 expression, and three also expressed CD7.
    Conclusions: Myeloblasts become megakaryoblastic over time in some MDS patients, and examining the megakaryocyte lineage (not only as a diagnostic work-up but also as follow-up) is needed to detect CD41+ MDS. The immunophenotypic features revealed in this study may have diagnostic relevance for CD41+ MDS patients.
    Mesh-Begriff(e) Humans ; Granulocyte Precursor Cells ; Immunophenotyping ; Megakaryocyte Progenitor Cells ; Retrospective Studies ; Antigens, CD34 ; Myelodysplastic Syndromes
    Chemische Substanzen Antigens, CD34
    Sprache Englisch
    Erscheinungsdatum 2023-09-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291662
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Myeloblasts transition to megakaryoblastic immunophenotypes over time in some patients with myelodysplastic syndromes.

    Kiyoyuki Ogata / Yuto Mochimaru / Kazuma Sei / Naoya Kawahara / Mika Ogata / Yumi Yamamoto

    PLoS ONE, Vol 18, Iss 9, p e

    2023  Band 0291662

    Abstract: Objectives In myelodysplastic syndromes (MDS), neoplastic myeloblast (CD34+CD13+CD33+ cells) numbers often increase over time, leading to secondary acute myeloid leukemia (AML). In recent studies, blasts in some MDS patients have been found to express a ... ...

    Abstract Objectives In myelodysplastic syndromes (MDS), neoplastic myeloblast (CD34+CD13+CD33+ cells) numbers often increase over time, leading to secondary acute myeloid leukemia (AML). In recent studies, blasts in some MDS patients have been found to express a megakaryocyte-lineage molecule, CD41, and such patients show extremely poor prognosis. This is the first study to evaluate whether myeloblasts transition to CD41+ blasts over time and to investigate the detailed immunophenotypic features of CD41+ blasts in MDS. Methods We performed a retrospective cohort study, in which time-dependent changes in blast immunophenotypes were analyzed using multidimensional flow cytometry (MDF) in 74 patients with MDS and AML (which progressed from MDS). Results CD41+ blasts (at least 20% of CD34+ blasts expressing CD41) were detected in 12 patients. In five of these 12 patients, blasts were CD41+ from the first MDF analysis. In the other seven patients, myeloblasts (CD34+CD33+CD41- cells) transitioned to megakaryoblasts (CD34+CD41+ cells) over time, which was often accompanied by disease progression (including leukemic transformation). These CD41+ patients were more frequently observed among patients with monosomal and complex karyotypes. CD41+ blasts were negative for the erythroid antigen, CD235a, and positive for CD33 in all cases, but CD33 expression levels were lower in three cases when compared with CD34+CD41- blasts. Among the five CD41+ patients who underwent extensive immunophenotyping, CD41+ blasts all expressed CD61, but two cases had reduced CD42b expression, three had reduced/absent CD13 expression, and three also expressed CD7. Conclusions Myeloblasts become megakaryoblastic over time in some MDS patients, and examining the megakaryocyte lineage (not only as a diagnostic work-up but also as follow-up) is needed to detect CD41+ MDS. The immunophenotypic features revealed in this study may have diagnostic relevance for CD41+ MDS patients.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Clinical, immunophenotypic, and cytogenetic characteristics of high-grade myelodysplastic syndromes with CD41-positive progenitor cells.

    Ogata, Kiyoyuki / Sei, Kazuma / Kawahara, Naoya / Ogata, Mika / Yamamoto, Yumi

    Cytometry. Part B, Clinical cytometry

    2021  Band 104, Heft 1, Seite(n) 98–107

    Abstract: Background: Patients with myelodysplastic syndromes (MDS) with progenitors expressing CD41 (CD41+ MDS) showed a poor prognosis in a previous study but their detailed characteristics remain unclear.: Methods: One hundred thirty-seven subjects at our ... ...

    Abstract Background: Patients with myelodysplastic syndromes (MDS) with progenitors expressing CD41 (CD41+ MDS) showed a poor prognosis in a previous study but their detailed characteristics remain unclear.
    Methods: One hundred thirty-seven subjects at our institution were diagnosed with excess blasts (EB)-1, EB-2, and acute myeloid leukemia with a low blast count (20%-30%). The immunophenotypes of progenitor cells in their bone marrow (BM) were determined by CD45-gating flow cytometry. A false-positive reaction to CD41 was eliminated by examining the flow cytometry data of lymphocytes and monocytes in addition to progenitors and by examining CD42b in histological sections. The characteristics were compared between CD41+ and CD41- MDS patients.
    Results: Forty-three patients (31%) were CD41+. Additionally, 91% of the CD41+ MDS patients were very high-risk defined by the Revised International Prognostic Score System, which was higher than in patients with CD41- MDS (p = 0.015). Approximately 60% of the CD41+ MDS patients had a monosomal karyotype and very poor cytogenetics, which was higher than in CD41- MDS patients (p < 0.001). Normal cytogenetics was less common in CD41+ patients (p = 0.0016). Blasts with bleb formation were more abundant in CD41+ MDS patients (p = 0.026). All CD41+ MDS patients were positive for CD13 and were mostly positive for CD33. The frequency of aberrant expression of other antigens on progenitors was similar between CD41+ and CD41- MDS patients.
    Conclusions: We determined clinical, immunophenotypic, and cytogenetic characteristics of CD41+ MDS patients. Further studies are needed to improve the survival of these patients.
    Mesh-Begriff(e) Humans ; Flow Cytometry ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/pathology ; Bone Marrow/pathology ; Karyotyping ; Stem Cells/pathology
    Sprache Englisch
    Erscheinungsdatum 2021-12-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2099657-3
    ISSN 1552-4957 ; 1552-4949 ; 0196-4763
    ISSN (online) 1552-4957
    ISSN 1552-4949 ; 0196-4763
    DOI 10.1002/cyto.b.22052
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Clinical significance of CD41-positive blasts in association with a monosomal karyotype in patients with myelodysplastic syndrome treated with azacitidine.

    Ogata, Kiyoyuki / Sei, Kazuma / Kawahara, Naoya / Yamamoto, Yumi

    British journal of haematology

    2020  Band 189, Heft 4, Seite(n) e144–e147

    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antimetabolites, Antineoplastic/pharmacology ; Antimetabolites, Antineoplastic/therapeutic use ; Azacitidine/pharmacology ; Azacitidine/therapeutic use ; Female ; Humans ; Karyotype ; Male ; Middle Aged ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/immunology ; Platelet Membrane Glycoprotein IIb/immunology ; Young Adult
    Chemische Substanzen Antimetabolites, Antineoplastic ; Platelet Membrane Glycoprotein IIb ; Azacitidine (M801H13NRU)
    Sprache Englisch
    Erscheinungsdatum 2020-03-04
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16565
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Flow cytometry will be a routine tool in clinical practice in myelodysplastic syndromes: a real story.

    Ogata, Kiyoyuki

    Leukemia research

    2011  Band 35, Heft 7, Seite(n) 848–849

    Mesh-Begriff(e) Flow Cytometry/methods ; Flow Cytometry/utilization ; Humans ; Myelodysplastic Syndromes/diagnosis ; Prognosis ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 2011-07
    Erscheinungsland England
    Dokumenttyp Comment ; Editorial
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2011.03.018
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  8. Artikel: [New horizons in MDS: flow cytometric diagnosis and a role of immunomodulatory molecules in disease progression].

    Ogata, Kiyoyuki

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2011  Band 52, Heft 3, Seite(n) 106–110

    Mesh-Begriff(e) Antigens, CD ; B7-H1 Antigen ; Disease Progression ; Flow Cytometry/methods ; Humans ; Interleukin-2 Receptor alpha Subunit ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/immunology
    Chemische Substanzen Antigens, CD ; B7-H1 Antigen ; CD274 protein, human ; Interleukin-2 Receptor alpha Subunit
    Sprache Japanisch
    Erscheinungsdatum 2011-03
    Erscheinungsland Japan
    Dokumenttyp Journal Article ; Review
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Diagnostic flow cytometry for low-grade myelodysplastic syndromes.

    Ogata, Kiyoyuki

    Hematological oncology

    2008  Band 26, Heft 4, Seite(n) 193–198

    Abstract: It has long been considered that flow cytometry (FCM) has little role in clinical practice in the diagnosis of myelodysplastic syndromes (MDS). However, recent advances in the analytical method and knowledge of MDS FCM are changing this stereotype. This ... ...

    Abstract It has long been considered that flow cytometry (FCM) has little role in clinical practice in the diagnosis of myelodysplastic syndromes (MDS). However, recent advances in the analytical method and knowledge of MDS FCM are changing this stereotype. This paper reviews the concept and current status of FCM in the diagnosis of low-grade MDS. The diagnosis of low-grade MDS in the absence of ringed sideroblasts and chromosomal aberration is not always straightforward, and a report from a recent international working conference has proposed FCM as an adjunctive diagnostic test for such cases. Currently, only a limited number of laboratories are applying FCM to the diagnosis of MDS. Furthermore, standard analytical methods in FCM for MDS have not been established, and no single FCM parameter is sufficiently sensitive and specific to make the diagnosis of MDS. To establish MDS FCM as a widely accepted, dependable diagnostic tool, prospective studies should increase flow parameters that can be analysed reproducibly and determine their sensitivity and specificity, either alone or in combination. CD34+ cell-related parameters that are applicable for diagnosing low-grade MDS in many laboratories are introduced here.
    Mesh-Begriff(e) Antigens, CD34/analysis ; Flow Cytometry/methods ; Forecasting ; Granulocyte Precursor Cells/metabolism ; Humans ; Leukocyte Common Antigens/analysis ; Myelodysplastic Syndromes/diagnosis ; Pattern Recognition, Visual ; Precursor Cells, B-Lymphoid/metabolism ; Reproducibility of Results ; Sensitivity and Specificity
    Chemische Substanzen Antigens, CD34 ; Leukocyte Common Antigens (EC 3.1.3.48)
    Sprache Englisch
    Erscheinungsdatum 2008-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.857
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Myelodysplastic syndromes: recent progress in diagnosis and understanding of their pathophysiology.

    Ogata, Kiyoyuki

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

    2006  Band 73, Heft 6, Seite(n) 300–307

    Abstract: Myelodysplastic syndromes (MDS) are common malignant disorders with a poor prognosis. MDS are a group of highly heterogeneous disorders but show certain universal findings including a high incidence in the elderly population, cytopenia, dysplastic ... ...

    Abstract Myelodysplastic syndromes (MDS) are common malignant disorders with a poor prognosis. MDS are a group of highly heterogeneous disorders but show certain universal findings including a high incidence in the elderly population, cytopenia, dysplastic myeloid cells, and frequent transformation to acute myeloid leukemia. Until recently, the vast majority of MDS patients were treated with supportive therapy alone, such as transfusions. Allogeneic stem cell transplantation (SCT) has the potential for cure, although due to the age and comorbidity of MDS patients, the role of allogeneic SCT in MDS has been limited. Recently, research in MDS has shown substantial advances that have deepened our understanding of MDS pathophysiology and changed our approach to MDS patients. This review touches on some recent developments in the diagnosis and pathophysiology of MDS.
    Mesh-Begriff(e) Apoptosis ; Cytogenetics ; Epigenesis, Genetic ; Flow Cytometry ; Humans ; Immunocompetence ; Leukemia, Myeloid, Acute ; Myelodysplastic Syndromes/classification ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/etiology ; T-Lymphocytes/immunology
    Sprache Englisch
    Erscheinungsdatum 2006-11-15
    Erscheinungsland Japan
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2091563-9
    ISSN 1347-3409 ; 1345-4676
    ISSN (online) 1347-3409
    ISSN 1345-4676
    DOI 10.1272/jnms.73.300
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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