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Artikel ; Online: Measuring PROMIS® Well-Being in Early Childhood.

Blackwell, Courtney K / Kallen, Michael A / Lai, Jin-Shei / Bevans, Katherine B / Wakschlag, Lauren S / Cella, David

2022 Band 47, Heft 5, Seite(n) 559–572

Abstract: Objective: Expand the current Patient-Reported Outcome Measurement Information System (PROMIS®) well-being measures to early childhood (1-5 years) using best practices from PROMIS and developmental science.: Methods: Qualitative methods included ... ...

Abstract	Objective: Expand the current Patient-Reported Outcome Measurement Information System (PROMIS®) well-being measures to early childhood (1-5 years) using best practices from PROMIS and developmental science. Methods: Qualitative methods included expert input, literature and measure review, and parent interviews to confirm measure frameworks, item understandability, and developmental appropriateness. Quantitative methods included two waves of field testing and item response theory (IRT)-based psychometric evaluation of reliability and validity, as well as IRT centering and item calibration. Correlational analyses with other PROMIS Early Childhood (EC) Parent Report measures and known-group differences analyses by health status were conducted to evaluate construct validity. All measures were normed to the general U.S. population. Results: Qualitative results suggested three primary early childhood well-being domains: Positive Affect, Engagement, and Self-Regulation. Quantitative results revealed a unidimensional factor structure for Positive Affect and multidimensional factor structures for Engagement and Self-Regulation, both of which had two factors accounting for >10% of modeled variance reflecting unique unidimensional domains. This resulted in five final PROMIS EC well-being measures: Positive Affect, Engagement-Curiosity, Engagement-Persistence, Self-Regulation-Flexibility, and Self-Regulation-Frustration Tolerance. Correlations and known-groups differences analyses showed robust construct validity across a range of chronic health conditions. Conclusions: The new PROMIS EC Parent Report well-being measures offer clinicians and researchers a brief, efficient, and precise way to evaluate young children's well-being. All five measures include only positively valanced item content, which pushes the field to evaluate the presence of children's positive assets rather than the absence of problems.
Mesh-Begriff(e)	Child ; Child, Preschool ; Chronic Disease ; Health Status ; Humans ; Patient Reported Outcome Measures ; Psychometrics/methods ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires
Sprache	Englisch
Erscheinungsdatum	2022-05-04
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	625329-5
ISSN	1465-735X ; 0146-8693
ISSN (online)	1465-735X
ISSN	0146-8693
DOI	10.1093/jpepsy/jsac030
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The Use of Methylphenidate During Inpatient Rehabilitation After Pediatric Traumatic Brain Injury: Population Characteristics and Prescribing Patterns.

Caliendo, Eric / Lowder, Ryan / McLaughlin, Matthew J / Watson, William D / Baum, Katherine T / Blackwell, Laura S / Koterba, Christine H / Hoskinson, Kristen R / Tlustos, Sarah J / Shah, Sudhin A / Suskauer, Stacy J / Kurowski, Brad G

The Journal of head trauma rehabilitation

2023 Band 39, Heft 3, Seite(n) E122–E131

Abstract: Objective: To understand how methylphenidate (MPH) is used in youth with traumatic brain injury (TBI) during inpatient pediatric rehabilitation.: Setting: Inpatient pediatric rehabilitation.: Participants: In total, 234 children with TBI; 62 of ... ...

Abstract	Objective: To understand how methylphenidate (MPH) is used in youth with traumatic brain injury (TBI) during inpatient pediatric rehabilitation. Setting: Inpatient pediatric rehabilitation. Participants: In total, 234 children with TBI; 62 of whom received MPH and 172 who did not. Patients were on average 11.6 years of age (range, 2 months to 21 years); 88 of 234 were female; the most common mechanism of injury was motor vehicle collision (49%); median (IQR) acute hospital length of stay (LOS) and inpatient rehabilitation LOS were 16 (10-29) and 23 (14-39), respectively; 51 of 234 were in a disorder of consciousness cognitive state at time of inpatient rehabilitation admission. Design: Multicenter, retrospective medical record review. Main measures: Patient demographic data, time to inpatient pediatric rehabilitation admission (TTA), cognitive state, MPH dosing (mg/kg/day). Results: Patients who received MPH were older (P = .011); TTA was significantly longer in patients who received MPH than those who did not (P =.002). The lowest recorded dose range by weight was 0.05 to 0.89 mg/kg/d, representing an 18-fold difference; the weight-based range for the maximum dose was 0.11 to 0.97 mg/kg/d, a 9-fold difference. Patients in lower cognitive states at admission (P = .001) and at discharge (P = .030) were more likely to receive MPH. Five patients had side effects known to be associated with MPH; no serious adverse events were reported. Conclusion: This multicenter study indicates that there is variable use of MPH during acute inpatient rehabilitation for children with TBI. Children who receive MPH tend to be older with lower cognitive states. Dosing practices are likely consistent with underdosing. Clinical indications for MPH use during inpatient pediatric rehabilitation should be better defined. The use of MPH, as well as its combination with other medications and treatments, during inpatient rehabilitation needs to be further explored.
Mesh-Begriff(e)	Humans ; Methylphenidate/therapeutic use ; Methylphenidate/administration & dosage ; Child ; Female ; Brain Injuries, Traumatic/rehabilitation ; Male ; Adolescent ; Child, Preschool ; Retrospective Studies ; Central Nervous System Stimulants/therapeutic use ; Central Nervous System Stimulants/administration & dosage ; Infant ; Practice Patterns, Physicians'/statistics & numerical data ; Young Adult ; Inpatients ; Length of Stay ; Rehabilitation Centers
Chemische Substanzen	Methylphenidate (207ZZ9QZ49) ; Central Nervous System Stimulants
Sprache	Englisch
Erscheinungsdatum	2023-08-14
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Multicenter Study
ZDB-ID	639221-0
ISSN	1550-509X ; 0885-9701
ISSN (online)	1550-509X
ISSN	0885-9701
DOI	10.1097/HTR.0000000000000889
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Estimating acoustic cue rates in bowhead whales, Balaena mysticetus, during their fall migration through the Alaskan Beaufort Sea.

Blackwell, Susanna B / Thode, Aaron M / Conrad, Alexander S / Ferguson, Megan C / Berchok, Catherine L / Stafford, Kathleen M / Marques, Tiago A / Kim, Katherine H

The Journal of the Acoustical Society of America

2021 Band 149, Heft 5, Seite(n) 3611

Abstract: Eight years of passive acoustic data (2007-2014) from the Beaufort Sea were used to estimate the mean cue rate (calling rate) of individual bowhead whales (Balaena mysticetus) during their fall migration along the North Slope of Alaska. Calls detected on ...

Abstract	Eight years of passive acoustic data (2007-2014) from the Beaufort Sea were used to estimate the mean cue rate (calling rate) of individual bowhead whales (Balaena mysticetus) during their fall migration along the North Slope of Alaska. Calls detected on directional acoustic recorders (DASARs) were triangulated to provide estimates of locations at times of call production, which were then translated into call densities (calls/h/km
Mesh-Begriff(e)	Acoustics ; Alaska ; Animals ; Bowhead Whale ; Cues ; Seasons
Sprache	Englisch
Erscheinungsdatum	2021-07-09
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0005043
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation.

Cardiovascular research

2024

Abstract: Aims: The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth factor signaling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to cardiovascular, inflammatory, and hematologic disorders including stroke. In ...

Abstract	Aims: The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth factor signaling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to cardiovascular, inflammatory, and hematologic disorders including stroke. In mice, deletion of Lnk causes inflammation and oxidative stress. We hypothesized that Lnk-/- mice are susceptible to atrial fibrillation (AF) and that rs3184504 is associated with AF and AF-related stroke in humans. During inflammation, reactive lipid dicarbonyls are a major component of oxidative injury, and we further hypothesized that these mediators are critical drivers of the AF substrate in Lnk-/- mice. Methods and results: Lnk-/- or wild-type (WT) mice were treated with vehicle or 2-hydroxybenzylamine (2-HOBA), a dicarbonyl scavenger, for 3 months. Compared to WT, Lnk-/- mice displayed increased AF duration that was prevented by 2-HOBA. In the Lnk-/- atria, action potentials were prolonged with reduced transient outward K+ current, increased late Na+ current, and reduced peak Na+ current, proarrhythmic effects that were inhibited by 2-HOBA. Mitochondrial dysfunction, especially for complex I, was evident in Lnk-/- atria, while scavenging lipid dicarbonyls prevented this abnormality. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were elevated in Lnk-/- plasma and atrial tissue, respectively, both of which caused electrical and bioenergetic remodeling in vitro. Inhibition of soluble TNF-α prevented electrical remodeling and AF susceptibility, while IL-1β inhibition improved mitochondrial respiration but had no effect on AF susceptibility. In a large database of genotyped patients, rs3184504 was associated with AF, as well as AF-related stroke. Conclusions: These findings identify a novel role for LNK in the pathophysiology of AF in both experimental mice and in humans. Moreover, reactive lipid dicarbonyls are critical to the inflammatory AF substrate in Lnk-/- mice and mediate the proarrhythmic effects of pro-inflammatory cytokines, primarily through electrical remodeling.
Sprache	Englisch
Erscheinungsdatum	2024-02-20
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvae036
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Weekly and Daily Tooth Brushing by Care Staff Reduces Gingivitis and Calculus in Racing Greyhounds.

Rooney, Nicola J / Wonham, Katharine L / McIndoe, Katherine S / Casey, Rachel A / Blackwell, Emily J / Browne, William J

Animals : an open access journal from MDPI

2021 Band 11, Heft 7

Abstract: Periodontal disease is one of the most common conditions affecting dogs worldwide and is reported to be particularly prevalent in racing greyhounds. A range of potential risk factors have been hypothesised. Previous research has suggested that regular ... ...

Abstract	Periodontal disease is one of the most common conditions affecting dogs worldwide and is reported to be particularly prevalent in racing greyhounds. A range of potential risk factors have been hypothesised. Previous research has suggested that regular tooth brushing can reduce both calculus and gingivitis, but the frequency required is unclear. Here, we report a controlled blinded in situ trial, in which kennel staff brushed 160 racing greyhounds' teeth (living at six kennel establishments), either weekly, daily or never over a two-month period. All of the visible teeth were scored for calculus and gingivitis, using previously validated scales. We calculated average scores for each of the three teeth groups and overall whole mouth scores, averaging the teeth groups. Changes were compared to the baseline. After two months, the total calculus scores (controlling for baseline) were significantly different in the three treatment groups, (F
Sprache	Englisch
Erscheinungsdatum	2021-06-23
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11071869
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Crowdsourcing medical education.

Blackwell, Katherine A / Travis, Michael J / Arbuckle, Melissa R / Ross, David A

Medical education

2016 Band 50, Heft 5, Seite(n) 576

Mesh-Begriff(e)	Crowdsourcing/methods ; Curriculum ; Education, Medical/methods ; Humans ; Neurosciences/education
Sprache	Englisch
Erscheinungsdatum	2016-05
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	195274-2
ISSN	1365-2923 ; 0308-0110
ISSN (online)	1365-2923
ISSN	0308-0110
DOI	10.1111/medu.13010
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Weekly and Daily Tooth Brushing by Care Staff Reduces Gingivitis and Calculus in Racing Greyhounds

Nicola J. Rooney / Katharine L. Wonham / Katherine S. McIndoe / Rachel A. Casey / Emily J. Blackwell / William J. Browne

Animals, Vol 11, Iss 1869, p

2021 Band 1869

Abstract	Periodontal disease is one of the most common conditions affecting dogs worldwide and is reported to be particularly prevalent in racing greyhounds. A range of potential risk factors have been hypothesised. Previous research has suggested that regular tooth brushing can reduce both calculus and gingivitis, but the frequency required is unclear. Here, we report a controlled blinded in situ trial, in which kennel staff brushed 160 racing greyhounds’ teeth (living at six kennel establishments), either weekly, daily or never over a two-month period. All of the visible teeth were scored for calculus and gingivitis, using previously validated scales. We calculated average scores for each of the three teeth groups and overall whole mouth scores, averaging the teeth groups. Changes were compared to the baseline. After two months, the total calculus scores (controlling for baseline) were significantly different in the three treatment groups, (F (2,129) = 10.76, p < 0.001) with both weekly and daily brushing resulting in significant reductions. Gingivitis was also significantly different between groups (F (2,128) = 4.57, p = 0.012), but in this case, only daily brushing resulted in a significant reduction. Although the dogs in different kennels varied significantly in their levels of both calculus (F (5,129) = 8.64, p < 0.001) and gingivitis (F (5,128) = 3.51 p = 0.005), the intervention was similarly effective in all of the establishments. The teeth groups varied, and the incisors were not significantly affected by the treatment. Since the trainers implementing the routine, reported a minimal time commitment and positive experiences, we suggest that daily brushing is recommended for racing greyhounds, and that any instructions or demonstrations should include attention to all teeth groups including the incisors. Similar trials need to be conducted with retired greyhounds since these have been shown to present particularly high levels of periodontal disease.
Schlagwörter	teeth ; greyhound ; intervention ; brushing ; calculus ; gingivitis ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Thema/Rubrik (Code)	630
Sprache	Englisch
Erscheinungsdatum	2021-06-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: A comparison of three methods for estimating call densities of migrating bowhead whales using passive acoustic monitoring

Oedekoven, Cornelia S. / Marques, Tiago A. / Harris, Danielle / Thomas, Len / Thode, Aaron M. / Blackwell, Susanna B. / Conrad, Alexander S. / Kim, Katherine H.

Environmental and ecological statistics. 2022 Mar., v. 29, no. 1

2022

Abstract: Various methods for estimating animal density from visual data, including distance sampling (DS) and spatially explicit capture-recapture (SECR), have recently been adapted for estimating call density using passive acoustic monitoring (PAM) data, e.g., ... ...

Abstract	Various methods for estimating animal density from visual data, including distance sampling (DS) and spatially explicit capture-recapture (SECR), have recently been adapted for estimating call density using passive acoustic monitoring (PAM) data, e.g., recordings of animal calls. Here we summarize three methods available for passive acoustic density estimation: plot sampling, DS, and SECR. The first two require distances from the sensors to calling animals (which are obtained by triangulating calls matched among sensors), but SECR only requires matching (not localizing) calls among sensors. We compare via simulation what biases can arise when assumptions underlying these methods are violated. We use insights gleaned from the simulation to compare the performance of the methods when applied to a case study: bowhead whale call data collected from arrays of directional acoustic sensors at five sites in the Beaufort Sea during the fall migration 2007–2014. Call detections were manually extracted from the recordings by human observers simultaneously scanning spectrograms of recordings from a given site. The large discrepancies between estimates derived using SECR and the other two methods were likely caused primarily by the manual detection procedure leading to non-independent detections among sensors, while errors in estimated distances between detected calls and sensors also contributed to the observed patterns. Our study is among the first to provide a direct comparison of the three methods applied to PAM data and highlights the importance that all assumptions of an analysis method need to be met for correct inference.
Schlagwörter	Balaena mysticetus ; acoustics ; animal density ; case studies ; humans ; mark-recapture studies ; statistics ; Beaufort Sea
Sprache	Englisch
Erscheinungsverlauf	2022-03
Umfang	p. 101-125.
Erscheinungsort	Springer US
Dokumenttyp	Artikel
ZDB-ID	2000906-9
ISSN	1573-3009 ; 1352-8505
ISSN (online)	1573-3009
ISSN	1352-8505
DOI	10.1007/s10651-021-00506-3
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF.

Agrawal, Vineet / Kropski, Jonathan A / Gokey, Jason J / Kobeck, Elizabeth / Murphy, Matthew B / Murray, Katherine T / Fortune, Niki L / Moore, Christy S / Meoli, David F / Monahan, Ken / Ru Su, Yan / Blackwell, Thomas / Gupta, Deepak K / Talati, Megha H / Gladson, Santhi / Carrier, Erica J / West, James D / Hemnes, Anna R

Circulation research

2023 Band 133, Heft 11, Seite(n) 885–898

Abstract: Background: Pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) is a common and highly morbid syndrome, but mechanisms driving PH-HFpEF are poorly understood. We sought to determine whether a well-accepted murine model ... ...

Abstract	Background: Pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) is a common and highly morbid syndrome, but mechanisms driving PH-HFpEF are poorly understood. We sought to determine whether a well-accepted murine model of HFpEF also displays features of PH, and we sought to identify pathways that might drive early remodeling of the pulmonary vasculature in HFpEF. Methods: Eight-week-old male and female C57BL/6J mice received either N Results: N Conclusions: We report a novel model for the study of PH and right heart remodeling in HFpEF, and we identify myeloid cell-derived IL-1β as an important contributor to PH in HFpEF.
Mesh-Begriff(e)	Animals ; Female ; Humans ; Male ; Mice ; Clodronic Acid ; Heart Failure/metabolism ; Hypertension, Pulmonary/etiology ; Interleukin-1beta ; Mice, Inbred C57BL ; Myeloid Cells/metabolism ; Stroke Volume/physiology
Chemische Substanzen	Clodronic Acid (0813BZ6866) ; Interleukin-1beta ; IL1B protein, mouse
Sprache	Englisch
Erscheinungsdatum	2023-11-06
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.123.323119
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Multiplatform Single-Cell Analysis Identifies Immune Cell Types Enhanced in Pulmonary Fibrosis.

Serezani, Ana P M / Pascoalino, Bruno D / Bazzano, Julia M R / Vowell, Katherine N / Tanjore, Harikrishna / Taylor, Chase J / Calvi, Carla L / McCall, A Scott / Bacchetta, Matthew D / Shaver, Ciara M / Ware, Lorraine B / Salisbury, Margaret L / Banovich, Nicholas E / Kendall, Peggy L / Kropski, Jonathan A / Blackwell, Timothy S

American journal of respiratory cell and molecular biology

2022 Band 67, Heft 1, Seite(n) 50–60

Abstract: Immune cells have been implicated in idiopathic pulmonary fibrosis (IPF), but the phenotypes and effector mechanisms of these cells remain incompletely characterized. We performed mass cytometry to quantify immune cell subsets in lungs of 12 patients ... ...

Abstract	Immune cells have been implicated in idiopathic pulmonary fibrosis (IPF), but the phenotypes and effector mechanisms of these cells remain incompletely characterized. We performed mass cytometry to quantify immune cell subsets in lungs of 12 patients with IPF and 15 organ donors without chronic lung disease and used existing single-cell RNA-sequencing data to investigate transcriptional profiles of immune cells overrepresented in IPF. Among myeloid cells, we found increased numbers of alveolar macrophages (AMØs) and dendritic cells (DCs) in IPF, as well as a subset of monocyte-derived DCs. In contrast, monocyte-like cells and interstitial macrophages were reduced in IPF. Transcriptomic profiling identified an enrichment for IFN-γ response pathways in AMØs and DCs from IPF, as well as antigen processing in DCs and phagocytosis in AMØs. Among T cells, we identified three subsets of memory T cells that were increased in IPF, including CD4
Mesh-Begriff(e)	Gene Expression Profiling ; Humans ; Idiopathic Pulmonary Fibrosis/pathology ; Lung/pathology ; Macrophages, Alveolar/metabolism ; Single-Cell Analysis
Sprache	Englisch
Erscheinungsdatum	2022-04-20
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2021-0418OC
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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