Artikel ; Online: Embryo manipulation and imprinting.
Seminars in reproductive medicine
2012 Band 30, Heft 4, Seite(n) 323–334
Abstract: As the use of assisted reproductive technologies (ART) continues to rise worldwide, it remains of the upmost importance to maintain the safety of those techniques used in ART. Many of these practices are unique to this discipline; as such, it becomes ... ...
Abstract | As the use of assisted reproductive technologies (ART) continues to rise worldwide, it remains of the upmost importance to maintain the safety of those techniques used in ART. Many of these practices are unique to this discipline; as such, it becomes difficult to assess the true risks that the potential offspring may be subjected to under this type of treatment. Removal of oocytes from a woman's body during an in vitro fertilization (IVF) cycle offers an increased opportunity for routine cellular processes to go awry. Specifically, epigenetic modifications and imprinting diseases are rare among the general population; however, although their incidence among IVF-conceived children is also rare, their frequency in this population remains elevated compared with universal rates. Recent investigations have directly attributed their occurrences to the use of ART and IVF to achieve a successful pregnancy. This review discusses the major cellular manipulations of a typical IVF cycle to assess the potential risks versus the reported risks. These manipulations include preimplantation genetic diagnosis and screening, intracytoplasmic sperm injection, ooplasmic transfer, embryo culture, in vitro maturation, and cryopreservation. Oocyte and embryo handling is a delicate part of the IVF process that continues to improve. The safety of those potential improvements is also discussed. |
---|---|
Mesh-Begriff(e) | Chromosome Disorders/etiology ; Chromosome Disorders/genetics ; Cryopreservation/methods ; DNA Methylation/physiology ; Embryo Culture Techniques/methods ; Female ; Fertilization in Vitro/methods ; Genomic Imprinting/physiology ; Humans ; Pregnancy ; Preimplantation Diagnosis/methods ; Sperm Injections, Intracytoplasmic/methods |
Sprache | Englisch |
Erscheinungsdatum | 2012-08 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 2042479-6 |
ISSN | 1526-4564 ; 1526-8004 |
ISSN (online) | 1526-4564 |
ISSN | 1526-8004 |
DOI | 10.1055/s-0032-1320013 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Se 881: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.