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  1. Artikel ; Online: What artificial intelligence knows about 70 kDa heat shock proteins, and how we will face this ChatGPT era.

    Heck, Thiago Gomes

    Cell stress & chaperones

    2023  Band 28, Heft 3, Seite(n) 225–229

    Mesh-Begriff(e) Artificial Intelligence ; Heat-Shock Proteins
    Chemische Substanzen Heat-Shock Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-04-14
    Erscheinungsland Netherlands
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-023-01340-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Cardioprotection during Chemotherapy: Prospects of Antioxidant Strategies.

    Heck, Thiago Gomes

    Arquivos brasileiros de cardiologia

    2022  Band 117, Heft 6, Seite(n) 1159–1160

    Titelübersetzung Cardioproteção durante a Quimioterapia: Perspectivas de Estratégias com Antioxidantes.
    Mesh-Begriff(e) Antioxidants/therapeutic use ; Humans ; Myocardial Reperfusion Injury
    Chemische Substanzen Antioxidants
    Sprache Portugiesisch
    Erscheinungsdatum 2022-05-25
    Erscheinungsland Brazil
    Dokumenttyp Editorial ; Comment
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20210914
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: New Insights into the Role of Oxidative Stress in the Development of Diabetes Mellitus and Its Complications.

    Dos Santos, Julia Matzenbacher / Zhong, Qing / Benite-Ribeiro, Sandra A / Heck, Thiago Gomes

    Journal of diabetes research

    2023  Band 2023, Seite(n) 9824864

    Mesh-Begriff(e) Humans ; Oxidative Stress ; Diabetes Mellitus, Type 2 ; Diabetes Mellitus ; Antioxidants ; Diabetes Complications
    Chemische Substanzen Antioxidants
    Sprache Englisch
    Erscheinungsdatum 2023-07-26
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2023/9824864
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR).

    Schroeder, Helena Trevisan / De Lemos Muller, Carlos Henrique / Heck, Thiago Gomes / Krause, Mauricio / Homem de Bittencourt, Paulo Ivo

    Cell stress & chaperones

    2024  Band 29, Heft 1, Seite(n) 66–87

    Abstract: ... inflammatory disorders. Therefore, the Heck index, contrasting extracellular 70 kDa family ...

    Abstract Effective resolution of inflammation via the heat shock response (HSR) is pivotal in averting the transition to chronic inflammatory states. This transition characterizes a spectrum of debilitating conditions, including insulin resistance, obesity, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular ailments. This manuscript explores a range of physiological, pharmacological, and nutraceutical interventions aimed at reinstating the HSR in the context of chronic low-grade inflammation, as well as protocols to assess the HSR. Monitoring the progression or suppression of the HSR in patients and laboratory animals offers predictive insights into the organism's capacity to combat chronic inflammation, as well as the impact of exercise and hyperthermic treatments (e.g., sauna or hot tub baths) on the HSR. Interestingly, a reciprocal correlation exists between the expression of HSR components in peripheral blood leukocytes (PBL) and the extent of local tissue proinflammatory activity in individuals afflicted by chronic inflammatory disorders. Therefore, the Heck index, contrasting extracellular 70 kDa family of heat shock proteins (HSP70) (proinflammatory) and intracellular HSP70 (anti-inflammatory) in PBL, serves as a valuable metric for HSR assessment. Our laboratory has also developed straightforward protocols for evaluating HSR by subjecting whole blood samples from both rodents and human volunteers to ex vivo heat challenges. Collectively, this discussion underscores the critical role of HSR disruption in the pathogenesis of chronic inflammatory states and emphasizes the significance of simple, cost-effective tools for clinical HSR assessment. This understanding is instrumental in the development of innovative strategies for preventing and managing chronic inflammatory diseases, which continue to exert a substantial global burden on morbidity and mortality.
    Mesh-Begriff(e) Animals ; Humans ; Diabetes Mellitus, Type 2 ; Heat-Shock Response ; Heat-Shock Proteins/metabolism ; HSP70 Heat-Shock Proteins/metabolism ; Inflammation ; Chronic Disease
    Chemische Substanzen Heat-Shock Proteins ; HSP70 Heat-Shock Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1016/j.cstres.2024.01.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The dance of proteostasis and metabolism: Unveiling the caloristatic controlling switch.

    Schroeder, Helena Trevisan / De Lemos Muller, Carlos Henrique / Heck, Thiago Gomes / Krause, Mauricio / Homem de Bittencourt, Paulo Ivo

    Cell stress & chaperones

    2024  Band 29, Heft 1, Seite(n) 175–200

    Abstract: The heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger ... ...

    Abstract The heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger the HSR. This interplay between proteostasis and energy regulation is rooted in the fundamental need for ATP to fuel protein synthesis and repair, making the HSR an essential component of cellular energy management. Recent findings suggest that the origins of proteostasis-defending systems can be traced back over 3.6 billion years, aligning with the emergence of sugar kinases that optimized glycolysis around 3.594 billion years ago. This evolutionary connection is underscored by the spatial similarities between the nucleotide-binding domain of HSP70, the key player in protein chaperone machinery, and hexokinases. The HSR serves as a hub that integrates energy metabolism and resolution of inflammation, further highlighting its role in maintaining cellular homeostasis. Notably, 5'-adenosine monophosphate-activated protein kinase emerges as a central regulator, promoting the HSR during predominantly proteotoxic stress while suppressing it in response to predominantly metabolic stress. The complex relationship between 5'-adenosine monophosphate-activated protein kinase and the HSR is finely tuned, with paradoxical effects observed under different stress conditions. This delicate equilibrium, known as caloristasis, ensures that cellular homeostasis is maintained despite shifting environmental and intracellular conditions. Understanding the caloristatic controlling switch at the heart of this interplay is crucial. It offers insights into a wide range of conditions, including glycemic control, obesity, type 2 diabetes, cardiovascular and neurodegenerative diseases, reproductive abnormalities, and the optimization of exercise routines. These findings highlight the profound interconnectedness of proteostasis and energy metabolism in cellular function and adaptation.
    Mesh-Begriff(e) Humans ; Proteostasis ; Diabetes Mellitus, Type 2 ; HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Response ; Adenosine Monophosphate/metabolism ; Protein Kinases/metabolism
    Chemische Substanzen HSP70 Heat-Shock Proteins ; Adenosine Monophosphate (415SHH325A) ; Protein Kinases (EC 2.7.-)
    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1016/j.cstres.2024.02.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases.

    Schroeder, Helena Trevisan / De Lemos Muller, Carlos Henrique / Heck, Thiago Gomes / Krause, Mauricio / Homem de Bittencourt, Paulo Ivo

    Cell stress & chaperones

    2024  Band 29, Heft 1, Seite(n) 116–142

    Abstract: The heat shock response (HSR) is a crucial biochemical pathway that orchestrates the resolution of inflammation, primarily under proteotoxic stress conditions. This process hinges on the upregulation of heat shock proteins (HSPs) and other chaperones, ... ...

    Abstract The heat shock response (HSR) is a crucial biochemical pathway that orchestrates the resolution of inflammation, primarily under proteotoxic stress conditions. This process hinges on the upregulation of heat shock proteins (HSPs) and other chaperones, notably the 70 kDa family of heat shock proteins, under the command of the heat shock transcription factor-1. However, in the context of chronic degenerative disorders characterized by persistent low-grade inflammation (such as insulin resistance, obesity, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular diseases) a gradual suppression of the HSR does occur. This work delves into the mechanisms behind this phenomenon. It explores how the Western diet and sedentary lifestyle, culminating in the endoplasmic reticulum stress within adipose tissue cells, trigger a cascade of events. This cascade includes the unfolded protein response and activation of the NOD-like receptor pyrin domain-containing protein-3 inflammasome, leading to the emergence of the senescence-associated secretory phenotype and the propagation of inflammation throughout the body. Notably, the activation of the NOD-like receptor pyrin domain-containing protein-3 inflammasome not only fuels inflammation but also sabotages the HSR by degrading human antigen R, a crucial mRNA-binding protein responsible for maintaining heat shock transcription factor-1 mRNA expression and stability on heat shock gene promoters. This paper underscores the imperative need to comprehend how chronic inflammation stifles the HSR and the clinical significance of evaluating the HSR using cost-effective and accessible tools. Such understanding is pivotal in the development of innovative strategies aimed at the prevention and treatment of these chronic inflammatory ailments, which continue to take a heavy toll on global health and well-being.
    Mesh-Begriff(e) Humans ; Heat Shock Transcription Factors ; Diabetes Mellitus, Type 2 ; Inflammasomes/metabolism ; Inflammasomes/pharmacology ; Heat-Shock Response ; Heat-Shock Proteins/metabolism ; Inflammation ; RNA, Messenger ; NLR Proteins/metabolism ; HSP70 Heat-Shock Proteins/metabolism
    Chemische Substanzen Heat Shock Transcription Factors ; Inflammasomes ; Heat-Shock Proteins ; RNA, Messenger ; NLR Proteins ; HSP70 Heat-Shock Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1016/j.cstres.2024.01.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Inflammation, oxidative stress and altered heat shock response in type 2 diabetes: the basis for new pharmacological and non-pharmacological interventions.

    Hirsch, Gabriela Elisa / Heck, Thiago Gomes

    Archives of physiology and biochemistry

    2019  Band 128, Heft 2, Seite(n) 411–425

    Abstract: Type 2 diabetes mellitus (DM2) is a chronic disease characterised by variable degrees of insulin resistance and impaired insulin secretion. Besides, several pieces of evidence have shown that chronic inflammation, oxidative stress, and 70 kDa heat shock ... ...

    Abstract Type 2 diabetes mellitus (DM2) is a chronic disease characterised by variable degrees of insulin resistance and impaired insulin secretion. Besides, several pieces of evidence have shown that chronic inflammation, oxidative stress, and 70 kDa heat shock proteins (HSP70) are strongly involved in DM2 and its complications, and various pharmacological and non-pharmacological treatment alternatives act in these processes/molecules to modulate them and ameliorate the disease. Besides, uncontrolled hyperglycaemia is related to several complications as diabetic retinopathy, neuropathy and hepatic, renal and cardiac complications. In this review, we address discuss the involvement of different inflammatory and pro-oxidant pathways related to DM2, and we described molecular targets modulated by therapeutics currently available to treat DM2.
    Mesh-Begriff(e) Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/therapy ; Heat-Shock Response ; Humans ; Inflammation/metabolism ; Insulin Resistance ; Oxidative Stress
    Sprache Englisch
    Erscheinungsdatum 2019-11-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2019.1687522
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Oxidative stress and decreased tissue HSP70 are involved in the genesis of sepsis: HSP70 as a therapeutic target.

    Sulzbacher, Maicon Machado / Ludwig, Mirna Stela / Heck, Thiago Gomes

    Revista Brasileira de terapia intensiva

    2020  Band 32, Heft 4, Seite(n) 585–591

    Abstract: Sepsis is a systemic infection that causes multiple organ dysfunction. HSP70 is a protein responsive to cell stress, in particular oxidative stress. Therefore, this literature review sought to investigate the roles of HSP70 and oxidative stress in the ... ...

    Titelübersetzung Estresse oxidativo e diminuição de HSP70 tecidual envolvidos na gênese da sepse: HSP70 como alvo terapêutico.
    Abstract Sepsis is a systemic infection that causes multiple organ dysfunction. HSP70 is a protein responsive to cell stress, in particular oxidative stress. Therefore, this literature review sought to investigate the roles of HSP70 and oxidative stress in the pathophysiology of sepsis and the possibility of HSP70 as a therapeutic target. HSP70 exerts a protective effect when located in cells (iHSP70), and its decrease, as well as its increase in the extracellular environment (eHSP70), under oxidative stress is a biomarker of sepsis severity. In addition, therapies that increase iHSP70 and treatment with HSP70 promote sepsis improvement.
    Mesh-Begriff(e) Biomarkers/metabolism ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Oxidative Stress ; Sepsis
    Chemische Substanzen Biomarkers ; HSP70 Heat-Shock Proteins
    Sprache Englisch
    Erscheinungsdatum 2020-12-03
    Erscheinungsland Brazil
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2732162-9
    ISSN 1982-4335 ; 0103-507X
    ISSN (online) 1982-4335
    ISSN 0103-507X
    DOI 10.5935/0103-507X.20200084
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A MULTIDISCIPLINARIEDADE E DIMENSÃO REGIONAL E NACIONAL DA REVISTA CONTEXTO & SAÚDE

    Thiago Gomes Heck

    Revista Contexto & Saúde, Vol 15, Iss

    2015  Band 29

    Abstract: ... ...

    Abstract Editorial
    Schlagwörter Saúde ; editorial ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2015-12-01T00:00:00Z
    Verlag Editora Unijuí
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: O QUE HÁ DE NOVO NO “NOVO” CONTEXTO DA REVISTA CONTEXTO & SAÚDE?

    Thiago Gomes Heck

    Revista Contexto & Saúde, Vol 15, Iss

    2015  Band 28

    Abstract: Editorial. ...

    Abstract Editorial.
    Schlagwörter Editoração de revista ; Indexação de Revista ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2015-08-01T00:00:00Z
    Verlag Editora Unijuí
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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