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Artikel: Update on transfusion-related acute lung injury.

Toy, Pearl

Clinical advances in hematology & oncology : H&O

2019 Band 17, Heft 7, Seite(n) 378–381

Mesh-Begriff(e)	Humans ; Transfusion-Related Acute Lung Injury/diagnosis ; Transfusion-Related Acute Lung Injury/epidemiology ; Transfusion-Related Acute Lung Injury/pathology ; Transfusion-Related Acute Lung Injury/therapy
Sprache	Englisch
Erscheinungsdatum	2019-08-26
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	2271951-9
ISSN	1543-0790
ISSN	1543-0790
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Antibodies associated with TRALI: differences in clinical relevance.

Kopko, Patricia M / Bux, Jürgen / Toy, Pearl

Transfusion

2018 Band 59, Heft 3, Seite(n) 1147–1151

Mesh-Begriff(e)	Antibodies/immunology ; Blood Donors ; Female ; Humans ; Male ; Transfusion Reaction/immunology ; Transfusion-Related Acute Lung Injury/immunology
Chemische Substanzen	Antibodies
Sprache	Englisch
Erscheinungsdatum	2018-12-13
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.15094
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021).

Toy, Pearl / Looney, Mark R / Popovsky, Mark / Palfi, Miodrag / Berlin, Gösta / Chapman, Catherine E / Bolton-Maggs, Paula / Matthay, Michael A

Annals of the American Thoracic Society

2022 Band 19, Heft 5, Seite(n) 705–712

Abstract: The term transfusion-related acute lung injury (TRALI) was coined in 1985 to describe acute respiratory distress syndrome (ARDS) after transfusion, when another ARDS risk factor was absent; TRALI cases were mostly associated with donor leukocyte antibody. ...

Abstract	The term transfusion-related acute lung injury (TRALI) was coined in 1985 to describe acute respiratory distress syndrome (ARDS) after transfusion, when another ARDS risk factor was absent; TRALI cases were mostly associated with donor leukocyte antibody. In 2001, plasma from multiparous donors was implicated in TRALI in a randomized controlled trial in Sweden. In 2003 and in many years thereafter, the U.S. Food and Drug Administration reported that TRALI was the leading cause of death from transfusion in the United States. In 2003, the United Kingdom was the first among many countries to successfully reduce TRALI using male-predominant plasma. These successes are to be celebrated. Nevertheless, questions remain about the mechanisms of non-antibody TRALI, the role of blood products in the development of ARDS in patients receiving massive transfusion, the causes of unusual TRALI cases, and how to reduce inaccurate diagnoses of TRALI in clinical practice. Regarding the latter, a study in 2013-2015 at 169 U.S. hospitals found that many TRALI diagnoses did not meet clinical definitions. In 2019, a consensus panel established a more precise terminology for clinical diagnosis: TRALI type I and TRALI type II are cases where transfusion is the likely cause, and ARDS are cases where transfusion is not the likely cause. For accurate diagnosis using these clinical definitions, critical care or pulmonary expertise is needed to distinguish between permeability versus hydrostatic pulmonary edema, to determine whether an ARDS risk factor is present, and, if so, to determine whether respiratory function was stable within the 12 hours before transfusion.
Mesh-Begriff(e)	Blood Transfusion ; Humans ; Male ; Pulmonary Edema/etiology ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Transfusion Reaction/complications ; Transfusion-Related Acute Lung Injury/complications ; Transfusion-Related Acute Lung Injury/diagnosis
Sprache	Englisch
Erscheinungsdatum	2022-01-19
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202108-963CME
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reply to concerns regarding dropping the term "possible TRALI".

Toy, Pearl / Kleinman, Steven H / Looney, Mark R

Transfusion

2016 Band 56, Heft 9, Seite(n) 2394–2395

Sprache	Englisch
Erscheinungsdatum	2016-09
Erscheinungsland	United States
Dokumenttyp	Letter
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.13734
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Proposed revised nomenclature for transfusion-related acute lung injury.

Toy, Pearl / Kleinman, Steven H / Looney, Mark R

Transfusion

2017 Band 57, Heft 3, Seite(n) 709–713

Abstract: A decade ago, definitions of "transfusionߚrelated acute lung injury (TRALI)" and "possible TRALI" were standardized for research and clinical diagnosis. Since then, evidence has confirmed that TRALI is often due to transfusion of white blood cell ... ...

Abstract	A decade ago, definitions of "transfusionߚrelated acute lung injury (TRALI)" and "possible TRALI" were standardized for research and clinical diagnosis. Since then, evidence has confirmed that TRALI is often due to transfusion of white blood cell antibodies to at-risk patients, and the term "TRALI, antibody mediated" is appropriate for such cases. Other TRALI cases are non-antibody mediated. Because specific, nonantibody transfusion factors have not yet been confirmed to cause TRALI in humans, the general term "TRALI, non-antibody mediated" is appropriate for such cases. In contrast, evidence is against possible TRALI being due to transfusion with the more likely cause of the acute respiratory distress syndrome (ARDS) being the alternative ARDS risk factor present in these patients. We propose to drop the misleading term "possible TRALI" and to rename this category of cases as "transfused ARDS." These nomenclature updates will more accurately categorize ARDS cases that develop after transfusion.
Mesh-Begriff(e)	Acute Lung Injury/blood ; Acute Lung Injury/classification ; Humans ; Respiratory Distress Syndrome, Adult/blood ; Respiratory Distress Syndrome, Adult/classification ; Risk Factors ; Transfusion Reaction/blood ; Transfusion Reaction/classification
Sprache	Englisch
Erscheinungsdatum	2017-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.13944
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: An update of the transfusion-related acute lung injury (TRALI) definition.

Vlaar, Alexander P J / Toy, Pearl / Fung, Mark / Looney, Mark R / Juffermans, Nicole P / Bux, Juergen / Bolton-Maggs, P / Peters, Anna L / Silliman, Christopher C / Kor, Daryl J / Kleinman, Steve

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

2019 Band 26, Heft 4, Seite(n) 354–356

Mesh-Begriff(e)	Canada ; Delphi Technique ; Humans ; Respiratory Distress Syndrome, Adult/etiology ; Terminology as Topic ; Transfusion Reaction ; Transfusion-Related Acute Lung Injury
Sprache	Englisch
Erscheinungsdatum	2019-06-12
Erscheinungsland	France
Dokumenttyp	Letter
ZDB-ID	1204698-x
ISSN	1953-8022 ; 1246-7820
ISSN (online)	1953-8022
ISSN	1246-7820
DOI	10.1016/j.tracli.2019.05.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury.

Sayah, David M / Looney, Mark R / Toy, Pearl

Critical care clinics

2012 Band 28, Heft 3, Seite(n) 363–72, v

Abstract: Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. TRALI presents as acute lung injury (ALI) within 6 hours after blood product transfusion. Diagnosing TRALI requires a high index of suspicion, and the ... ...

Abstract	Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. TRALI presents as acute lung injury (ALI) within 6 hours after blood product transfusion. Diagnosing TRALI requires a high index of suspicion, and the exclusion of circulatory overload or other causes of ALI. The pathophysiology of TRALI is incompletely understood, but in part involves transfusion of certain anti-neutrophil antibodies, anti-HLA antibodies, or other bioactive substances, into susceptible recipients. Recent studies have identified both recipient and transfusion risk factors for the development of TRALI. This article describes these TRALI risk factors, as well as diagnosis, treatment and prevention strategies.
Mesh-Begriff(e)	Acute Lung Injury/epidemiology ; Acute Lung Injury/etiology ; Acute Lung Injury/physiopathology ; Acute Lung Injury/prevention & control ; Acute Lung Injury/therapy ; Blood Group Incompatibility ; Humans ; Incidence ; Risk Factors ; Transfusion Reaction
Sprache	Englisch
Erscheinungsdatum	2012-06-19
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1006423-0
ISSN	1557-8232 ; 0749-0704
ISSN (online)	1557-8232
ISSN	0749-0704
DOI	10.1016/j.ccc.2012.04.001
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: TRALI--definition, mechanisms, incidence and clinical relevance.

Toy, Pearl / Lowell, Clifford

Best practice & research. Clinical anaesthesiology

2007 Band 21, Heft 2, Seite(n) 183–193

Abstract: Transfusion-related acute lung injury (TRALI) is defined as new acute lung injury (ALI) that occurs during or within six hours of transfusion, not explained by another ALl risk factor. Transfusion of part of one unit of any blood product can cause TRALI. ...

Abstract	Transfusion-related acute lung injury (TRALI) is defined as new acute lung injury (ALI) that occurs during or within six hours of transfusion, not explained by another ALl risk factor. Transfusion of part of one unit of any blood product can cause TRALI. The mechanism may include factors in unit(s) of blood, such as antibody and biologic response modifiers. In addition, yet to be described factors in a patient's illness may predispose to the condition. The current incidence is estimated to be 1 in 5000 units. Patients present with acute dyspnea, or froth in the endotracheal tube in intubated patients. Hypertension, hypotension, acute leukopenia have been described. Management is similar to that for ALI and is predominantly supportive. When TRALI is suspected, Blood banks should be notified to quarantine other components from the same donation. No special blood product is required for subsequent transfusion of a patient who has developed TRALI.
Mesh-Begriff(e)	Blood Donors ; Genetic Predisposition to Disease ; Humans ; Incidence ; Practice Guidelines as Topic ; Pulmonary Edema/epidemiology ; Pulmonary Edema/etiology ; Respiratory Distress Syndrome, Adult/epidemiology ; Respiratory Distress Syndrome, Adult/etiology ; Risk Assessment ; Risk Factors ; Transfusion Reaction
Sprache	Englisch
Erscheinungsdatum	2007-07-03
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1499424-0
ISSN	1521-6896
ISSN	1521-6896
DOI	10.1016/j.bpa.2007.01.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Eradicating hepatitis B virus: The critical role of preventing perinatal transmission.

Stevens, Cladd E / Toy, Pearl / Kamili, Saleem / Taylor, Patricia E / Tong, Myron J / Xia, Guo-Liang / Vyas, Girish N

Biologicals : journal of the International Association of Biological Standardization

2017 Band 50, Seite(n) 3–19

Abstract: Prevention of hepatitis B virus (HBV) transmission from infected mothers to their newborns is critical to HBV control and eventual eradication. Mother-to-child perinatal transmission causes the highest chronic carrier rate (>85%) with a high rate of ... ...

Abstract	Prevention of hepatitis B virus (HBV) transmission from infected mothers to their newborns is critical to HBV control and eventual eradication. Mother-to-child perinatal transmission causes the highest chronic carrier rate (>85%) with a high rate of subsequent chronic liver disease and hepatocellular carcinoma. This risk is reduced by 90% with HBV vaccine given along with hepatitis B immune globulin (HBIG) starting at birth. New analyses of our data from US trials of HBIG and HBV vaccine in high-risk infants revealed better efficacy with yeast-recombinant vaccine than plasma-derived vaccine, especially in preventing late onset infections, with evidence that vaccine prevented transmission of maternal HBV infection with the glycine to arginine mutation in surface antigen codon 145 (sG145R). Most late infections with sG145R were in vaccine non-responders, suggesting escape from HBIG rather than from vaccine-induced antibody. Our findings also help explain survey results from Taiwan following universal childhood immunization implemented in the mid-1980s. We conclude that current vaccines will remain effective against surface antigen mutants. Anti-viral drugs in high-risk pregnant women, in combination with newborn HBIG and vaccine, show promise for eliminating residual breakthrough neonatal infections, critical to meeting WHO 2030 goals and for eradicating HBV.
Mesh-Begriff(e)	Adult ; Female ; Hepatitis B/immunology ; Hepatitis B/transmission ; Hepatitis B/virology ; Hepatitis B Vaccines/immunology ; Hepatitis B Vaccines/therapeutic use ; Hepatitis B virus/drug effects ; Hepatitis B virus/immunology ; Hepatitis B virus/physiology ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Pregnancy ; Pregnancy Complications, Infectious/immunology ; Pregnancy Complications, Infectious/prevention & control ; Pregnancy Complications, Infectious/virology
Chemische Substanzen	Hepatitis B Vaccines
Sprache	Englisch
Erscheinungsdatum	2017-11
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	1017370-5
ISSN	1095-8320 ; 1045-1056
ISSN (online)	1095-8320
ISSN	1045-1056
DOI	10.1016/j.biologicals.2017.08.008
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery.

Feiner, John R / Gropper, Michael A / Toy, Pearl / Lieberman, Jeremy / Twiford, Jenifer / Weiskopf, Richard B

Anesthesiology

2015 Band 123, Heft 1, Seite(n) 126–135

Abstract: Background: Transfusion-related acute lung injury incidence remains the leading cause of posttransfusion mortality. The etiology may be related to leukocyte antibodies or biologically active compounds in transfused plasma, injuring susceptible recipient' ...

Abstract	Background: Transfusion-related acute lung injury incidence remains the leading cause of posttransfusion mortality. The etiology may be related to leukocyte antibodies or biologically active compounds in transfused plasma, injuring susceptible recipient's lungs. The authors have hypothesized that transfusion could have less severe effects that are not always appreciated clinically and have shown subtly decreased pulmonary oxygen gas transfer in healthy volunteers after transfusion of fresh and 21-day stored erythrocytes. In this study, the authors tested the same hypothesis in surgical patients. Methods: Ninety-one patients undergoing elective major spine surgery with anticipated need for erythrocyte transfusion were randomly allocated to receive their first transfusion of erythrocytes as cell salvage (CS), washed stored, or unwashed stored. Clinicians were not blinded to group assignment. Pulmonary gas transfer and mechanics were measured 5 min before and 30 min after erythrocyte transfusion. Results: The primary outcome variable, gas transfer, as assessed by change of PaO2/FIO2, with erythrocyte transfusion was not significant in any group (mean ± SD; CS: 9 ± 59; washed: 10 ± 26; and unwashed: 15 ± 1) and did not differ among groups (P = 0.92). Pulmonary dead space (VD/VT) decreased with CS transfusion (-0.01 ± 0.04; P = 0.034) but did not change with other erythrocytes; the change from before to after erythrocyte transfusion did not differ among groups (-0.01 to +0.01; P = 0.28). Conclusions: The authors did not find impaired gas exchange as assessed by PaO2/FIO2 with transfused erythrocytes that did or did not contain nonautologous plasma. This clinical trial did not support the hypothesis of erythrocyte transfusion-induced gas exchange deficit that had been found in healthy volunteers.
Mesh-Begriff(e)	Acute Lung Injury/diagnosis ; Acute Lung Injury/etiology ; Adolescent ; Adult ; Aged ; Elective Surgical Procedures/adverse effects ; Elective Surgical Procedures/trends ; Erythrocyte Transfusion/adverse effects ; Erythrocyte Transfusion/trends ; Female ; Humans ; Intraoperative Complications/diagnosis ; Intraoperative Complications/etiology ; Male ; Middle Aged ; Pulmonary Gas Exchange/physiology ; Young Adult
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2015-07
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000000689
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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