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Artikel ; Online: Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease.

Komuro, Mariko / Nagane, Masaki / Endo, Rikito / Nakamura, Takashi / Miyamoto, Takayoshi / Niwa, Chiaki / Fukuyama, Tomoki / Harashima, Hideyoshi / Aihara, Naoyuki / Kamiie, Junichi / Suzuki, Rimina / Yamashita, Tadashi

Biochemical and biophysical research communications

2022 Band 599, Seite(n) 24–30

Abstract: ... by excessive activation of T cells. Glycosphingolipids (GSLs) are composed of lipid rafts in cellular membranes ... and T cells from the spleen. Furthermore, the knockdown of Ugcg in T cells exacerbated ... nanoparticles prevented DSS-induced colitis. These results suggested that GlcCer in T cells is involved ...

Abstract	Inflammatory bowel disease (IBD) is a chronic inflammatory disease in the colon characterized by excessive activation of T cells. Glycosphingolipids (GSLs) are composed of lipid rafts in cellular membranes, and their content is linked to immune cell function. In the present study, we investigated the involvement of GSLs in IBD. Microarray data showed that in IBD patients, the expression of only UDP-glucose ceramide glucosyltransferase (UGCG) decreased among the GSLs synthases. Ad libitum access to dextran sulfate sodium (DSS) resulted in decreased UGCG and glucosylceramide (GlcCer) content in mesenteric lymph nodes and T cells from the spleen. Furthermore, the knockdown of Ugcg in T cells exacerbated the pathogenesis of colitis, which was accompanied by a decrease in Treg levels. Treatment with GlcCer nanoparticles prevented DSS-induced colitis. These results suggested that GlcCer in T cells is involved in the pathogenesis of IBD. Furthermore, GlcCer nanoparticles are a potential efficacious therapeutic target for IBD patients.
Mesh-Begriff(e)	Animals ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/pathology ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Glucosylceramides/administration & dosage ; Glucosylceramides/genetics ; Glucosylceramides/metabolism ; Glucosyltransferases/genetics ; Glucosyltransferases/metabolism ; Humans ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/pathology ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Mice
Chemische Substanzen	Glucosylceramides ; Dextran Sulfate (9042-14-2) ; Glucosyltransferases (EC 2.4.1.-) ; ceramide glucosyltransferase (EC 2.4.1.80)
Sprache	Englisch
Erscheinungsdatum	2022-02-03
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.02.004
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease

Biochemical and biophysical research communications. 2022 Apr. 09, v. 599

2022

Abstract	Inflammatory bowel disease (IBD) is a chronic inflammatory disease in the colon characterized by excessive activation of T cells. Glycosphingolipids (GSLs) are composed of lipid rafts in cellular membranes, and their content is linked to immune cell function. In the present study, we investigated the involvement of GSLs in IBD. Microarray data showed that in IBD patients, the expression of only UDP-glucose ceramide glucosyltransferase (UGCG) decreased among the GSLs synthases. Ad libitum access to dextran sulfate sodium (DSS) resulted in decreased UGCG and glucosylceramide (GlcCer) content in mesenteric lymph nodes and T cells from the spleen. Furthermore, the knockdown of Ugcg in T cells exacerbated the pathogenesis of colitis, which was accompanied by a decrease in Treg levels. Treatment with GlcCer nanoparticles prevented DSS-induced colitis. These results suggested that GlcCer in T cells is involved in the pathogenesis of IBD. Furthermore, GlcCer nanoparticles are a potential efficacious therapeutic target for IBD patients.
Schlagwörter	colitis ; colon ; dextran sulfate ; glucosylceramides ; lymph ; microarray technology ; pathogenesis ; research ; spleen ; therapeutics
Sprache	Englisch
Erscheinungsverlauf	2022-0409
Umfang	p. 24-30.
Erscheinungsort	Elsevier Inc.
Dokumenttyp	Artikel
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.02.004
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Feasibility of a T-Shirt-Type Wearable Electrocardiography Monitor for Detection of Covert Atrial Fibrillation in Young Healthy Adults.

Fukuma, Nobuaki / Hasumi, Eriko / Fujiu, Katsuhito / Waki, Kayo / Toyooka, Tsuguyoshi / Komuro, Issei / Ohe, Kazuhiko

Scientific reports

2019 Band 9, Heft 1, Seite(n) 11768

Abstract: ... screening for asymptomatic AF using a wireless single-lead ECG with an electrode embedded in a T-shirt. One ... was detected in 2 participants (2.0%). The T-shirt-type wearable ECG monitoring system was suitable ...

Abstract	Covert atrial fibrillation (AF) accounts for cryptogenic stroke aetiology in elderly patients and in younger populations. However, asymptomatic AF is difficult to diagnose based on a short electrocardiography (ECG) recording. We evaluated the feasibility of a self-applied continuous ECG monitoring device that can record automatically, easily, and noninvasively in a younger population. We investigated community screening for asymptomatic AF using a wireless single-lead ECG with an electrode embedded in a T-shirt. One hundred men with a CHADS2 score ≥1 who were free from AF and <65 years of age were enrolled. We instructed the participants to wear ECG monitoring devices for at least 4 days/week over 2 months. The proportion of participants with newly detected AF (NDAF) and the monitoring time were evaluated. The mean CHADS2 score was 1.43 ± 0.62. The mean patient age was 52.5 ± 5.4 years. The mean monitoring time was 222 ± 199 hours. NDAF continuing for >30 seconds was detected in 10 participants (10.0%). AF continuing for >6 minutes was detected in 2 participants (2.0%). The T-shirt-type wearable ECG monitoring system was suitable for continuous, daily long-term use among young people with high physical activity, and it had the distinct capability of identifying covert AF.
Mesh-Begriff(e)	Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Electrocardiography, Ambulatory/instrumentation ; Feasibility Studies ; Female ; Humans ; Male ; Wearable Electronic Devices
Sprache	Englisch
Erscheinungsdatum	2019-08-13
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-48267-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Regulatory B1a Cells Suppress Melanoma Tumor Immunity via IL-10 Production and Inhibiting T Helper Type 1 Cytokine Production in Tumor-Infiltrating CD8

Kobayashi, Tadahiro / Oishi, Kyosuke / Okamura, Ai / Maeda, Shintaro / Komuro, Akito / Hamaguchi, Yasuhito / Fujimoto, Manabu / Takehara, Kazuhiko / Matsushita, Takashi

The Journal of investigative dermatology

2019 Band 139, Heft 7, Seite(n) 1535–1544.e1

Abstract: In tumor immunity, the participation of IL-10-producing regulatory B cells (Bregs), which play an important role in suppressing immune responses, is unclear. In this study, we demonstrated an increase in B16F10 melanoma growth and a decrease in the ... ...

Abstract	In tumor immunity, the participation of IL-10-producing regulatory B cells (Bregs), which play an important role in suppressing immune responses, is unclear. In this study, we demonstrated an increase in B16F10 melanoma growth and a decrease in the proportion of IFN-γ- and TNF-α-secreting tumor-infiltrating CD8
Mesh-Begriff(e)	Animals ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/transplantation ; B-Lymphocytes, Regulatory/immunology ; B-Lymphocytes, Regulatory/transplantation ; CD8-Positive T-Lymphocytes/immunology ; Cytokines/metabolism ; Humans ; Immune Tolerance ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Lymphocytes, Tumor-Infiltrating/immunology ; Melanoma/immunology ; Melanoma, Experimental ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplasms, Experimental ; PTEN Phosphohydrolase/genetics ; Th1 Cells/immunology
Chemische Substanzen	Cytokines ; Interleukin-10 (130068-27-8) ; PTEN Phosphohydrolase (EC 3.1.3.67)
Sprache	Englisch
Erscheinungsdatum	2019-03-02
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2019.02.016
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Raman spectroscopic detection of the T-Hg II-T base pair and the ionic characteristics of mercury.

Uchiyama, Tomomi / Miura, Takashi / Takeuchi, Hideo / Dairaku, Takenori / Komuro, Tomoyuki / Kawamura, Takuya / Kondo, Yoshinori / Benda, Ladislav / Sychrovsky, Vladimír / Bour, Petr / Okamoto, Itaru / Ono, Akira / Tanaka, Yoshiyuki

Nucleic acids research

2012 Band 40, Heft 12, Seite(n) 5766–5774

Abstract: ... mediated T-T (T-Hg(II)-T) base pair by Raman spectroscopy, which revealed the unique physical and ... contributor in the thymine ring of the T-Hg(II)-T pair. This resonance includes the N-Hg(II)-bonded state (Hg ... reduced the bond order of N-Hg(II). Consequently, the Hg(II) nucleus in the T-Hg(II)-T pair exhibited ...

Abstract	Developing applications for metal-mediated base pairs (metallo-base-pair) has recently become a high-priority area in nucleic acid research, and physicochemical analyses are important for designing and fine-tuning molecular devices using metallo-base-pairs. In this study, we characterized the Hg(II)-mediated T-T (T-Hg(II)-T) base pair by Raman spectroscopy, which revealed the unique physical and chemical properties of Hg(II). A characteristic Raman marker band at 1586 cm(-1) was observed and assigned to the C4=O4 stretching mode. We confirmed the assignment by the isotopic shift ((18)O-labeling at O4) and density functional theory (DFT) calculations. The unusually low wavenumber of the C4=O4 stretching suggested that the bond order of the C4=O4 bond reduced from its canonical value. This reduction of the bond order can be explained if the enolate-like structure (N3=C4-O4(-)) is involved as a resonance contributor in the thymine ring of the T-Hg(II)-T pair. This resonance includes the N-Hg(II)-bonded state (Hg(II)-N3-C4=O4) and the N-Hg(II)-dissociated state (Hg(II+) N3=C4-O4(-)), and the latter contributor reduced the bond order of N-Hg(II). Consequently, the Hg(II) nucleus in the T-Hg(II)-T pair exhibited a cationic character. Natural bond orbital (NBO) analysis supports the interpretations of the Raman experiments.
Mesh-Begriff(e)	Base Pairing ; Cations/chemistry ; Mercury/chemistry ; Spectrum Analysis, Raman ; Thymine/chemistry
Chemische Substanzen	Cations ; Mercury (FXS1BY2PGL) ; Thymine (QR26YLT7LT)
Sprache	Englisch
Erscheinungsdatum	2012-03-01
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gks208
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch: Atlas of interstitial cells of cajal in the gastrointestinal tract

Komuro, Terumasa

2012

Verfasserangabe	Terumasa Komuro
Schlagwörter	Pacemaker cells--Atlases ; Gastrointestinal system--Atlases
Sprache	Englisch
Umfang	XII, 134 S. : zahlr. Ill., 24 cm
Verlag	Springer
Erscheinungsort	Dordrecht u.a.
Erscheinungsland	Niederlande
Dokumenttyp	Buch
Begleitmaterial	1 3D-Brille
HBZ-ID	HT017225194
ISBN	978-94-007-2916-2 ; 94-007-2916-2 ; 9789400729179 ; 9400729170
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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Artikel ; Online: Subclinical elevation of high-sensitive troponin T levels at the convalescent stage is associated with increased 5-year mortality after ST-elevation myocardial infarction.

Hara, Masahiko / Sakata, Yasuhiko / Nakatani, Daisaku / Suna, Shinichiro / Nishino, Masami / Sato, Hiroshi / Kitamura, Tetsuhisa / Nanto, Shinsuke / Hamasaki, Toshimitsu / Hori, Masatsugu / Komuro, Issei

Journal of cardiology

2016 Band 67, Heft 4, Seite(n) 314–320

Abstract: Background: It is unclear whether serum high-sensitive troponin T (hs-TnT) levels ...

Abstract	Background: It is unclear whether serum high-sensitive troponin T (hs-TnT) levels at the convalescent stage of ST-elevation myocardial infarction (STEMI) are associated with long-term mortality. Methods: This study enrolled a total of 2944 consecutive STEMI patients who were registered in the Osaka Acute Coronary Insufficiency Study between 2000 and 2009, and whose hs-TnT levels were evaluated at the convalescent stage. Patients were divided into four hs-TnT category groups according to the results of survival classification and regression tree (CART) analysis. The impact of hs-TnT levels on 5-year mortality was evaluated using multivariate Cox regression analysis. Results: Only one patient had hs-TnT level below the detection limit of the assay (<0.003ng/mL). The median hs-TnT level was 0.025 (quartile 0.011-0.083)ng/mL. During the median follow-up period of 1782 days, 188 patients died. Survival CART analysis revealed that the 1st, 2nd, and 3rd discriminating hs-TnT levels to discern 5-year mortality were 0.028, 0.008, and 1.340ng/mL, respectively. The adjusted hazard ratios for the medium-low (0.009-0.028ng/mL), medium-high (0.029-1.340ng/mL), and high-risk (≥1.341ng/mL) groups were 3.03 (95% confidence interval 1.18-7.77, p=0.021), 4.29 (1.63-11.28, p=0.003), and 8.68 (2.20-34.27, p=0.002), respectively. Integrated discrimination improvement (IDI) analysis revealed that incorporation of this hs-TnT classification scheme with other clinical variables statistically improved the discriminatory accuracy for 5-year mortality, with a time-dependent IDI of 0.0076 (p=0.033). Conclusions: hs-TnT levels at the convalescent stage were associated with long-term mortality in STEMI patients. Even subclinical elevation of hs-TnT levels was associated with increased 5-year mortality.
Mesh-Begriff(e)	Aged ; Convalescence ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/mortality ; Myocardial Infarction/pathology ; Proportional Hazards Models ; Prospective Studies ; Regression Analysis ; Survival Analysis ; Troponin T/blood
Chemische Substanzen	Troponin T
Sprache	Englisch
Erscheinungsdatum	2016-04
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2015.08.021
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Systemic DC Activation Modulates the Tumor Microenvironment and Shapes the Long-Lived Tumor-Specific Memory Mediated by CD8+ T Cells.

Shimizu, Kanako / Yamasaki, Satoru / Shinga, Jun / Sato, Yusuke / Watanabe, Takashi / Ohara, Osamu / Kuzushima, Kiyotaka / Yagita, Hideo / Komuro, Yoshiko / Asakura, Miki / Fujii, Shin-Ichiro

Cancer research

2016 Band 76, Heft 13, Seite(n) 3756–3766

Abstract: ... by establishing tertiary lymphoid structures (TLS), which include expanded antigen-specific CD8(+) T-cell clones ... T-cell clones, leading to the formation of long-term memory T cells. When combined with PD-1 ... blockade alone, as well as expansion of antigen-specific CD8(+) T-cell clones in the tumor. The findings ...

Abstract	Strategies to reprogram the tumor microenvironment are being explored to improve cancer immunotherapy. In one approach, we have targeted dendritic cells (DC) to improve their function with adjuvant vector cells (aAVC) that are engineered from NKT ligand-loaded CD1d(+) allogeneic cells transfected with tumor antigen mRNAs. Here, we report the finding that this approach also programs local immune responses by establishing tertiary lymphoid structures (TLS), which include expanded antigen-specific CD8(+) T-cell clones, mobilized DCs, and normalized tumor vasculature. aAVC therapy also expanded specific Vβ-expressing antitumor T-cell clones, leading to the formation of long-term memory T cells. When combined with PD-1 blockade, aAVC infusion triggered regression of poorly immunogenic tumor cells that did not respond to PD-1 blockade alone, as well as expansion of antigen-specific CD8(+) T-cell clones in the tumor. The findings of this study help to inform a next-generation platform for the generation of efficacious cancer vaccines. Cancer Res; 76(13); 3756-66. ©2016 AACR.
Mesh-Begriff(e)	Adjuvants, Immunologic ; Animals ; Antigens, Neoplasm ; CD8-Positive T-Lymphocytes/immunology ; Cancer Vaccines/immunology ; Dendritic Cells/immunology ; Female ; Humans ; Immunologic Memory/immunology ; Immunotherapy ; Lymphocyte Activation ; Male ; Melanoma, Experimental/immunology ; Melanoma, Experimental/pathology ; Melanoma, Experimental/therapy ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Tumor Cells, Cultured ; Tumor Microenvironment/immunology ; Xenograft Model Antitumor Assays
Chemische Substanzen	Adjuvants, Immunologic ; Antigens, Neoplasm ; Cancer Vaccines
Sprache	Englisch
Erscheinungsdatum	2016--01
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-15-3219
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Feasibility of a T-Shirt-Type Wearable Electrocardiography Monitor for Detection of Covert Atrial Fibrillation in Young Healthy Adults

Nobuaki Fukuma / Eriko Hasumi / Katsuhito Fujiu / Kayo Waki / Tsuguyoshi Toyooka / Issei Komuro / Kazuhiko Ohe

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Band 6

Abstract	Abstract Covert atrial fibrillation (AF) accounts for cryptogenic stroke aetiology in elderly patients and in younger populations. However, asymptomatic AF is difficult to diagnose based on a short electrocardiography (ECG) recording. We evaluated the feasibility of a self-applied continuous ECG monitoring device that can record automatically, easily, and noninvasively in a younger population. We investigated community screening for asymptomatic AF using a wireless single-lead ECG with an electrode embedded in a T-shirt. One hundred men with a CHADS2 score ≥1 who were free from AF and <65 years of age were enrolled. We instructed the participants to wear ECG monitoring devices for at least 4 days/week over 2 months. The proportion of participants with newly detected AF (NDAF) and the monitoring time were evaluated. The mean CHADS2 score was 1.43 ± 0.62. The mean patient age was 52.5 ± 5.4 years. The mean monitoring time was 222 ± 199 hours. NDAF continuing for >30 seconds was detected in 10 participants (10.0%). AF continuing for >6 minutes was detected in 2 participants (2.0%). The T-shirt-type wearable ECG monitoring system was suitable for continuous, daily long-term use among young people with high physical activity, and it had the distinct capability of identifying covert AF.
Schlagwörter	Medicine ; R ; Science ; Q
Thema/Rubrik (Code)	150
Sprache	Englisch
Erscheinungsdatum	2019-08-01T00:00:00Z
Verlag	Nature Publishing Group
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Pure intracerebral mass lesion of adult T-cell leukemia/lymphoma--case report.

Komuro, Taro / Okamoto, Shinichiro

Neurologia medico-chirurgica

2010 Band 50, Heft 6, Seite(n) 492–494

Abstract: A 48-year-old female presented with a rare case of adult T-cell leukemia/lymphoma (ATL) occurring ...

Abstract	A 48-year-old female presented with a rare case of adult T-cell leukemia/lymphoma (ATL) occurring as only intracerebral mass lesion manifesting as progressively worsening headaches, transient mild weakness of the left lower extremity, bilateral papilledema, and left homonymous hemianopsia. Laboratory examination showed transient leukocytosis (15900/microl) without febrile episode or elevation of C-reactive protein. Neuroimaging revealed a solitary enhanced mass lesion in the right occipital lobe adjacent to the choroid plexus with prominent perifocal edema. The patient underwent gross total removal, and the histological diagnosis was intracerebral ATL. She underwent radiation therapy and chemotherapy after local recurrence and metastasis to an optic nerve. The lesions had disappeared on magnetic resonance imaging with contrast medium 10 months after onset and no recurrence was detected even 5 years later. Intracerebral ATL should be considered in the differential diagnosis of intracerebral mass without leukemia or systemic lymphoma.
Mesh-Begriff(e)	Brain Neoplasms/diagnosis ; Brain Neoplasms/therapy ; Female ; Humans ; Leukemia-Lymphoma, Adult T-Cell/diagnosis ; Leukemia-Lymphoma, Adult T-Cell/therapy ; Middle Aged ; Neoplasm Recurrence, Local/prevention & control ; Occipital Lobe/pathology ; Occipital Lobe/surgery ; Treatment Outcome
Sprache	Englisch
Erscheinungsdatum	2010-06-25
Erscheinungsland	Japan
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	604061-5
ISSN	1349-8029 ; 0470-8105
ISSN (online)	1349-8029
ISSN	0470-8105
DOI	10.2176/nmc.50.492
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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