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  1. Artikel: Contraintes réglementaires des échanges de ressources biologiques à l'international : quand la biodiversité s'invite là où on ne l'attend pas….

    Mathieu, Cyrille

    Virologie (Montrouge, France)

    2020  Band 20, Heft 2, Seite(n) 73–74

    Titelübersetzung Contraintes réglementaires des échanges de ressources biologiques à l’international : quand la biodiversité s’invite là où on ne l’attend pas….
    Sprache Englisch
    Erscheinungsdatum 2020-09-11
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 2118387-9
    ISSN 1950-6961 ; 1267-8694
    ISSN (online) 1950-6961
    ISSN 1267-8694
    DOI 10.1684/vir.2016.0648
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Viral-induced neuroinflammation: Different mechanisms converging to similar exacerbated glial responses.

    Rocamonde, Brenda / Hasan, Uzma / Mathieu, Cyrille / Dutartre, Hélène

    Frontiers in neuroscience

    2023  Band 17, Seite(n) 1108212

    Abstract: There is increasing evidence that viral infections are the source/origin of various types of encephalitis, encephalomyelitis, and other neurological and cognitive disorders. While the involvement of certain viruses, such as the Nipah virus and measles ... ...

    Abstract There is increasing evidence that viral infections are the source/origin of various types of encephalitis, encephalomyelitis, and other neurological and cognitive disorders. While the involvement of certain viruses, such as the Nipah virus and measles virus, is known, the mechanisms of neural invasion and the factors that trigger intense immune reactions are not fully understood. Based on recent publications, this review discusses the role of the immune response, interactions between viruses and glial cells, and cytokine mediators in the development of inflammatory diseases in the central nervous system. It also highlights the significant gaps in knowledge regarding these mechanisms.
    Sprache Englisch
    Erscheinungsdatum 2023-03-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1108212
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Host-Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans.

    Escudero-Pérez, Beatriz / Lalande, Alexandre / Mathieu, Cyrille / Lawrence, Philip

    Viruses

    2023  Band 15, Heft 3

    Abstract: Emerging infectious diseases of zoonotic origin are an ever-increasing public health risk and economic burden. The factors that determine if and when an animal virus is able to spill over into the human population with sufficient success to achieve ... ...

    Abstract Emerging infectious diseases of zoonotic origin are an ever-increasing public health risk and economic burden. The factors that determine if and when an animal virus is able to spill over into the human population with sufficient success to achieve ongoing transmission in humans are complex and dynamic. We are currently unable to fully predict which pathogens may appear in humans, where and with what impact. In this review, we highlight current knowledge of the key host-pathogen interactions known to influence zoonotic spillover potential and transmission in humans, with a particular focus on two important human viruses of zoonotic origin, the Nipah virus and the Ebola virus. Namely, key factors determining spillover potential include cellular and tissue tropism, as well as the virulence and pathogenic characteristics of the pathogen and the capacity of the pathogen to adapt and evolve within a novel host environment. We also detail our emerging understanding of the importance of steric hindrance of host cell factors by viral proteins using a "flytrap"-type mechanism of protein amyloidogenesis that could be crucial in developing future antiviral therapies against emerging pathogens. Finally, we discuss strategies to prepare for and to reduce the frequency of zoonotic spillover occurrences in order to minimize the risk of new outbreaks.
    Mesh-Begriff(e) Animals ; Humans ; Zoonoses ; Host-Pathogen Interactions ; Communicable Diseases, Emerging/epidemiology ; Viruses ; Public Health
    Sprache Englisch
    Erscheinungsdatum 2023-02-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15030599
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Interféron de type I et sélectivité de l’infection des cellules du système nerveux central par le virus de la rougeole.

    Ferren, Marion / Horvat, Branka / Gerlier, Denis / Mathieu, Cyrille

    Medecine sciences : M/S

    2021  Band 37, Heft 1, Seite(n) 22–25

    Titelübersetzung Type I interferon and selective permissiveness of central nervous system to measles virus infection.
    Mesh-Begriff(e) Animals ; Antigens, Viral/analysis ; Brain/immunology ; Central Nervous System Viral Diseases/virology ; Dendritic Cells/virology ; Encephalitis, Viral/virology ; Humans ; Interferon Type I/metabolism ; Macrophages, Alveolar/virology ; Measles virus/immunology ; Mice ; Mice, Transgenic/metabolism ; Receptor, Interferon alpha-beta/deficiency ; Receptor, Interferon alpha-beta/genetics ; Signaling Lymphocytic Activation Molecule Family Member 1/metabolism ; Virus Internalization
    Chemische Substanzen Antigens, Viral ; Interferon Type I ; Slamf1 protein, mouse ; Receptor, Interferon alpha-beta (156986-95-7) ; Signaling Lymphocytic Activation Molecule Family Member 1 (169535-43-7)
    Sprache Französisch
    Erscheinungsdatum 2021-01-25
    Erscheinungsland France
    Dokumenttyp News ; Research Support, Non-U.S. Gov't
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020252
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Predictive factors of a viral neutralizing humoral response after a third dose of COVID-19 mRNA vaccine.

    Charmetant, Xavier / Espi, Maxime / Barba, Thomas / Ovize, Anne / Morelon, Emmanuel / Mathieu, Cyrille / Thaunat, Olivier

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2022  Band 22, Heft 5, Seite(n) 1442–1450

    Abstract: Kidney transplant recipients (KTRs) have reduced ability to mount adequate antibody response after two doses of the COVID-19 mRNA vaccine. French health authorities have allowed a third booster dose (D3) for KTRs, but their response is heterogeneous and ... ...

    Abstract Kidney transplant recipients (KTRs) have reduced ability to mount adequate antibody response after two doses of the COVID-19 mRNA vaccine. French health authorities have allowed a third booster dose (D3) for KTRs, but their response is heterogeneous and tools able to discriminate the responders are lacking. Anti-RBD IgG titers (chemiluminescence immunoassay), spike-specific cellular responses (IFN-γ-releasing assay, IGRA), and in vitro serum neutralization of the virus (the best available correlate of protection), were evaluated 7-14 days after the second dose (D2) of BNT162b2 vaccine in 93 KTRs. Among the 73 KTRs, whose serum did not neutralize SARS-CoV-2 in vitro after D2, 14 (19%) acquired this capacity after D3, and were considered as "responders." Exploratory univariate analysis identified short time from transplantation and high maintenance immunosuppression as detrimental factors for the response to D3. In addition, any of the presence of anti-RBD IgGs and/or positive IGRA after D2 was predictive of response to D3. By contrast, none of the KTRs with both a negative serology and IGRA responded to D3. In summary, routinely available bioassays performed after D2 allow identifying KTRs that will respond to a booster D3. These results pave the way for the personalization of vaccination strategy in KTRs.
    Mesh-Begriff(e) Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Kidney Transplantation ; SARS-CoV-2 ; Vaccines, Synthetic ; mRNA Vaccines
    Chemische Substanzen Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Vaccines, Synthetic ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Sprache Englisch
    Erscheinungsdatum 2022-02-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.16990
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  6. Artikel ; Online: Early Permissiveness of Central Nervous System Cells to Measles Virus Infection Is Determined by Hyperfusogenicity and Interferon Pressure.

    Ferren, Marion / Lalande, Alexandre / Iampietro, Mathieu / Canus, Lola / Decimo, Didier / Gerlier, Denis / Porotto, Matteo / Mathieu, Cyrille

    Viruses

    2023  Band 15, Heft 1

    Abstract: The cessation of measles virus (MeV) vaccination in more than 40 countries as a consequence of the COVID-19 pandemic is expected to significantly increase deaths due to measles. MeV can infect the central nervous system (CNS) and lead to lethal ... ...

    Abstract The cessation of measles virus (MeV) vaccination in more than 40 countries as a consequence of the COVID-19 pandemic is expected to significantly increase deaths due to measles. MeV can infect the central nervous system (CNS) and lead to lethal encephalitis. Substantial part of virus sequences recovered from patients' brain were mutated in the matrix and/or the fusion protein (F). Mutations of the heptad repeat domain located in the C terminal (HRC) part of the F protein were often observed and were associated to hyperfusogenicity. These mutations promote brain invasion as a hallmark of neuroadaptation. Wild-type F allows entry into the brain, followed by limited spreading compared with the massive invasion observed for hyperfusogenic MeV. Taking advantage of our ex vivo models of hamster organotypic brain cultures, we investigated how the hyperfusogenic mutations in the F HRC domain modulate virus distribution in CNS cells. In this study, we also identified the dependence of neural cells susceptibility on both their activation state and destabilization of the virus F protein. Type I interferon (IFN-I) impaired mainly astrocytes and microglial cells permissiveness contrarily to neurons, opening a new way of consideration on the development of treatments against viral encephalitis.
    Mesh-Begriff(e) Animals ; Cricetinae ; Humans ; Brain ; Central Nervous System/virology ; Interferons/metabolism ; Measles ; Measles virus/physiology ; Viral Fusion Proteins/genetics
    Chemische Substanzen Interferons (9008-11-1) ; Viral Fusion Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-01-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15010229
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Measles Encephalitis: Towards New Therapeutics

    Ferren, Marion / Horvat, Branka / Mathieu, Cyrille

    Viruses. 2019 Nov. 02, v. 11, no. 11

    2019  

    Abstract: Measles remains a major cause of morbidity and mortality worldwide among vaccine preventable diseases. Recent decline in vaccination coverage resulted in re-emergence of measles outbreaks. Measles virus (MeV) infection causes an acute systemic disease, ... ...

    Abstract Measles remains a major cause of morbidity and mortality worldwide among vaccine preventable diseases. Recent decline in vaccination coverage resulted in re-emergence of measles outbreaks. Measles virus (MeV) infection causes an acute systemic disease, associated in certain cases with central nervous system (CNS) infection leading to lethal neurological disease. Early following MeV infection some patients develop acute post-infectious measles encephalitis (APME), which is not associated with direct infection of the brain. MeV can also infect the CNS and cause sub-acute sclerosing panencephalitis (SSPE) in immunocompetent people or measles inclusion-body encephalitis (MIBE) in immunocompromised patients. To date, cellular and molecular mechanisms governing CNS invasion are still poorly understood. Moreover, the known MeV entry receptors are not expressed in the CNS and how MeV enters and spreads in the brain is not fully understood. Different antiviral treatments have been tested and validated in vitro, ex vivo and in vivo, mainly in small animal models. Most treatments have high efficacy at preventing infection but their effectiveness after CNS manifestations remains to be evaluated. This review describes MeV neural infection and current most advanced therapeutic approaches potentially applicable to treat MeV CNS infection.
    Schlagwörter Measles morbillivirus ; animal models ; brain ; encephalitis ; measles ; morbidity ; mortality ; patients ; receptors ; vaccination ; vaccines
    Sprache Englisch
    Erscheinungsverlauf 2019-1102
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11111017
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Glucosylceramide in bunyavirus particles is essential for virus binding to host cells.

    Uckeley, Zina M / Duboeuf, Maëva / Gu, Yu / Erny, Alexandra / Mazelier, Magalie / Lüchtenborg, Christian / Winter, Sophie L / Schad, Paulina / Mathieu, Cyrille / Koch, Jana / Boulant, Steeve / Chlanda, Petr / Maisse, Carine / Brügger, Britta / Lozach, Pierre-Yves

    Cellular and molecular life sciences : CMLS

    2024  Band 81, Heft 1, Seite(n) 71

    Abstract: Hexosylceramides (HexCer) are implicated in the infection process of various pathogens. However, the molecular and cellular functions of HexCer in infectious cycles are poorly understood. Investigating the enveloped virus Uukuniemi (UUKV), a bunyavirus ... ...

    Abstract Hexosylceramides (HexCer) are implicated in the infection process of various pathogens. However, the molecular and cellular functions of HexCer in infectious cycles are poorly understood. Investigating the enveloped virus Uukuniemi (UUKV), a bunyavirus of the Phenuiviridae family, we performed a lipidomic analysis with mass spectrometry and determined the lipidome of both infected cells and derived virions. We found that UUKV alters the processing of HexCer to glycosphingolipids (GSL) in infected cells. The infection resulted in the overexpression of glucosylceramide (GlcCer) synthase (UGCG) and the specific accumulation of GlcCer and its subsequent incorporation into viral progeny. UUKV and several pathogenic bunyaviruses relied on GlcCer in the viral envelope for binding to various host cell types. Overall, our results indicate that GlcCer is a structural determinant of virions crucial for bunyavirus infectivity. This study also highlights the importance of glycolipids on virions in facilitating interactions with host cell receptors and infectious entry of enveloped viruses.
    Mesh-Begriff(e) Orthobunyavirus ; Glucosylceramides ; Virus Attachment ; Lipidomics ; Mass Spectrometry
    Chemische Substanzen Glucosylceramides
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-023-05103-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 195: Hefte anzeigen Standort:
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  9. Artikel ; Online: Measles Encephalitis: Towards New Therapeutics.

    Ferren, Marion / Horvat, Branka / Mathieu, Cyrille

    Viruses

    2019  Band 11, Heft 11

    Abstract: Measles remains a major cause of morbidity and mortality worldwide among vaccine preventable diseases. Recent decline in vaccination coverage resulted in re-emergence of measles outbreaks. Measles virus (MeV) infection causes an acute systemic disease, ... ...

    Abstract Measles remains a major cause of morbidity and mortality worldwide among vaccine preventable diseases. Recent decline in vaccination coverage resulted in re-emergence of measles outbreaks. Measles virus (MeV) infection causes an acute systemic disease, associated in certain cases with central nervous system (CNS) infection leading to lethal neurological disease. Early following MeV infection some patients develop acute post-infectious measles encephalitis (APME), which is not associated with direct infection of the brain. MeV can also infect the CNS and cause sub-acute sclerosing panencephalitis (SSPE) in immunocompetent people or measles inclusion-body encephalitis (MIBE) in immunocompromised patients. To date, cellular and molecular mechanisms governing CNS invasion are still poorly understood. Moreover, the known MeV entry receptors are not expressed in the CNS and how MeV enters and spreads in the brain is not fully understood. Different antiviral treatments have been tested and validated in vitro, ex vivo and in vivo
    Mesh-Begriff(e) Animals ; Antiviral Agents/therapeutic use ; Central Nervous System/pathology ; Central Nervous System/virology ; Disease Models, Animal ; Encephalitis, Viral/drug therapy ; Encephalitis, Viral/epidemiology ; Encephalitis, Viral/pathology ; Encephalitis, Viral/virology ; Humans ; Measles/drug therapy ; Measles/epidemiology ; Measles/pathology ; Measles/virology ; Measles virus/pathogenicity ; Measles virus/physiology ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Viral Tropism
    Chemische Substanzen Antiviral Agents ; Viral Proteins
    Sprache Englisch
    Erscheinungsdatum 2019-11-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11111017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic tails govern CCHFV assembly.

    Gautam, Anupriya / Lalande, Alexandre / Ritter, Maureen / Freitas, Natalia / Lerolle, Solène / Canus, Lola / Amirache, Fouzia / Lotteau, Vincent / Legros, Vincent / Cosset, François-Loïc / Mathieu, Cyrille / Boson, Bertrand

    Emerging microbes & infections

    2024  , Seite(n) 2348508

    Abstract: ... ...

    Abstract Abstract
    Sprache Englisch
    Erscheinungsdatum 2024-04-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2024.2348508
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