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  1. AU="Shyamprasad, K" AU="Shyamprasad, K"
  2. AU=Tsuda Hiroyuki
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  1. Artikel ; Online: ViphyllinTM, a Standardized Black Pepper Extract Exerts Antihyperglycemic Effect and Improves Sciatic Nerve Conduction in High Fat Diet/Streptozotocin-Induced Diabetic Model Rats

    Ramanaiah I / Sudeep HV / Shyamprasad K

    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 15, Pp 1819-

    2022  Band 1829

    Abstract: Illuri Ramanaiah, Heggar Venkataramana Sudeep, Kodimule Shyamprasad Department of Preclinical Studies, R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, Karnataka, 560 105, IndiaCorrespondence: Heggar Venkataramana Sudeep, Department of ... ...

    Abstract Illuri Ramanaiah, Heggar Venkataramana Sudeep, Kodimule Shyamprasad Department of Preclinical Studies, R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, Karnataka, 560 105, IndiaCorrespondence: Heggar Venkataramana Sudeep, Department of Preclinical Studies, R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, Karnataka, 560 105, India, Tel +91 80-42094158, Email research@vidyaherbs.comPurpose: Research on plant-based formulations has drawn considerable attention in the management of diabetic neuropathy (DN) for having lesser side effects than the synthetic counterparts. Here, we have investigated for the first time the therapeutic effects of a standardized Piper nigrum L., (black pepper) seed extract, ViphyllinTM in mitigating hyperglycemia and neuropathic pain of type 2 diabetes model rats.Methods: Type 2 diabetes was induced in male Wistar rats using high fat diet and a single dose of streptozotocin (60 mg/kg i.p.). The diabetic rats were orally administered with Viphyllin containing not less than 30% β-caryophyllene (BCP), at 25 mg, 50 mg and 100 mg/kg/day doses for 6 weeks. Changes in body weight, fasting blood glucose (FBG), glucose tolerance, and blood biochemical parameters were measured. The nociceptive response to thermal stimulus (tail flick test) and sciatic nerve conduction velocity (NCV) were recorded at the end of study.Results: Viphyllin treatment markedly improved the body weight and glucose tolerance in diabetic rats. Also, the extract could significantly reduce the diabetes-induced elevation in FBG, liver and kidney indices. Further, Viphyllin dose-dependently increased the nociception latency in tail flick test compared to untreated diabetic rats (p< 0.05). Viphyllin at 100 mg/kg significantly increased the NCV (44.12± 1.91*** m/s vs diabetic control 25.80± 1.88 m/s). The antioxidant enzyme activities in sciatic nerve tissue were considerably increased in Viphyllin-treated groups compared to diabetic control. A 6-week treatment with Viphyllin markedly reversed the ...
    Schlagwörter diabetic neuropathy ; thermal hyperalgesia ; peripheral nerves ; black pepper ; Specialties of internal medicine ; RC581-951
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Dove Medical Press
    Dokumenttyp Artikel ; Online
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  2. Artikel: Molecular docking analysis of Withaferin A from Withania somnifera with the Glucose regulated protein 78 (GRP78) receptor and the SARS-CoV-2 main protease.

    Sudeep, H V / Gouthamchandra, K / Shyamprasad, K

    Bioinformation

    2020  Band 16, Heft 5, Seite(n) 411–417

    Abstract: Design and development of an effective compound to combat COVID-19 is clearly critical in the current circumstances. Therefore, it is of interest to document the molecular docking analysis data of the cellular receptor Glucose regulated protein 78 (GRP78) ...

    Abstract Design and development of an effective compound to combat COVID-19 is clearly critical in the current circumstances. Therefore, it is of interest to document the molecular docking analysis data of the cellular receptor Glucose regulated protein 78 (GRP78) with Withaferin A from Withania somnifera in the context of COVID-19 pandemic for further consideration. Here, we report the optimal interaction features of withaferin A, artemisinin, curcumin and andrographolide with the GRP78 receptor having low binding energies (-8.7, -7.89, -6.21 and -6.17 kcal/mol respectively) in this report. In order to gain additional insights, the interaction pattern of compounds with SARS-CoV-2 main protease (Mpro) was studied.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-30
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    ZDB-ID 2203786-X
    ISSN 0973-2063
    ISSN 0973-2063
    DOI 10.6026/97320630016411
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency.

    Sudeep, H V / Thomas, Jestin V / Shyamprasad, K

    BMC urology

    2020  Band 20, Heft 1, Seite(n) 86

    Abstract: Background: The present clinical trial was conducted to evaluate the efficacy and tolerability of a standardized saw palmetto oil containing 3% β-sitosterol in the treatment of benign prostate hyperplasia (BPH) and androgen deficiency.: Methods: ... ...

    Abstract Background: The present clinical trial was conducted to evaluate the efficacy and tolerability of a standardized saw palmetto oil containing 3% β-sitosterol in the treatment of benign prostate hyperplasia (BPH) and androgen deficiency.
    Methods: Subjects aged 40-65 years with symptomatic BPH were randomized to 12-week double-blind treatment with 500 mg doses of β-sitosterol enriched saw palmetto oil, conventional saw palmetto oil and placebo orally in the form of capsules (n = 33 in each group). BPH severity was determined using the International Prostate Symptom Score (IPSS), uroflowmetry, serum measurement of prostate specific antigen (PSA), testosterone and 5α-reductase. During the trial, the androgen deficiency was evaluated using Aging Male Symptoms (AMS) scale, the Androgen Deficiency in the Aging Male (ADAM) questionnaire, serum levels of free testosterone.
    Results: Subjects treated with β-sitosterol enriched saw palmetto oil showed significant decrease in IPSS, AMS and ADAM scores along with reduced postvoiding residual volume (p < 0.001), PSA (p < 0.01) and 5α-reductase from baseline to end of 12-week treatment as compared to placebo. There was also a significant increment in the maximum and average urine flow rate (p < 0.001), and serum free testosterone level of subjects treated with enriched saw palmetto oil as compared to placebo.
    Conclusion: This study demonstrates the efficacy of β-sitosterol enriched saw palmetto oil superior to conventional oil thus extending the scope of effective BPH and androgen deficiency treatment with improved quality of life through the intake of functional ingredients.
    Trial registration: CTRI/2018/12/016724 dated 19/12/2018 prospectively registered. URL: http://ctri.nic.in/Clinicaltrials/advsearch.php.
    Mesh-Begriff(e) Adult ; Aged ; Androgens/deficiency ; Double-Blind Method ; Humans ; Male ; Middle Aged ; Phytosterols/therapeutic use ; Phytotherapy ; Plant Extracts/therapeutic use ; Plant Oils/therapeutic use ; Prostatic Hyperplasia/drug therapy ; Sitosterols/therapeutic use ; Treatment Outcome ; Urological Agents/therapeutic use
    Chemische Substanzen Androgens ; Phytosterols ; Plant Extracts ; Plant Oils ; Sitosterols ; Urological Agents ; gamma-sitosterol (5LI01C78DD) ; saw palmetto extract (J7WWH9M8QS)
    Sprache Englisch
    Erscheinungsdatum 2020-07-03
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-020-00648-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: ViphyllinTM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels

    Venkatakrishna K / Sundeep K / Sudeep HV / Gouthamchandra K / Shyamprasad K

    Journal of Pain Research, Vol Volume 15, Pp 355-

    2022  Band 366

    Abstract: Karempudi Venkatakrishna, Kuppam Sundeep, Heggar Venkataramana Sudeep, Kuluvar Gouthamchandra, Kodimule Shyamprasad R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, 560 105, Karnataka, IndiaCorrespondence: Heggar Venkataramana Sudeep, Tel +91 ... ...

    Abstract Karempudi Venkatakrishna, Kuppam Sundeep, Heggar Venkataramana Sudeep, Kuluvar Gouthamchandra, Kodimule Shyamprasad R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, 560 105, Karnataka, IndiaCorrespondence: Heggar Venkataramana Sudeep, Tel +91 80-42094158, Email research@vidyaherbs.comPurpose: Plant-based natural products as anti-nociceptors have enormous potential as safer alternatives to conventional opiates and NSAIDS. Piper nigrum (black pepper) is one of the major culinary spices with medicinal attributes.Methods: In the present study, the antinociceptive activity of a standardized black pepper seed extract (Viphyllin) containing not less than 30% β-caryophyllene (BCP) was evaluated using pain models in mice, namely acetic acid-induced writhing test, formalin-induced paw licking test, hot plate test and tail flick test. Further, the antagonists SR141716A (0.1 mg/kg i.p.), AM630 (5 mg/kg i.p.), capsazepine (0.1 mg/kg body weight i.p.), and GW6471 (1 mg/kg i.p.) were used to evaluate the involvement of cannabinoid receptors CB1 and CB2, TRPV1 ion channel and PPARα receptor, respectively. Molecular docking (AutoDock 4.2) was used to study the interaction of BCP with the agonist-binding sites of the selected pain receptors.Results: Viphyllin at 10 mg, 25 mg and 50 mg/kg (i.p.) significantly inhibited the writhings in mice as compared to untreated control group (p < 0.001). Further, Viphyllin at 50 mg/kg showed strong antinociceptive effect in formalin-induced paw licking test (p < 0.05). Pretreatment of mice with AM630 significantly reversed the antinociceptive activity of Viphyllin in both early and late phases of formalin test (p < 0.05). Administration of Viphyllin markedly increased the latency time of mice in hot plate test (p < 0.001). Further, Viphyllin markedly increased the latency time of tail flick compared to control group from 30 min to 90 min after treatment. AM630, Capsazepine, and GW6471 abolished the analgesic effect of Viphyllin. These findings clearly suggest the ...
    Schlagwörter piper nigrum ; β-caryophyllene ; pain ; nociceptive receptors ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Dove Medical Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel: Viphyllin

    Ramanaiah, Illuri / Sudeep, Heggar Venkataramana / Shyamprasad, Kodimule

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2022  Band 15, Seite(n) 1819–1829

    Abstract: Purpose: Research on plant-based formulations has drawn considerable attention in the management of diabetic neuropathy (DN) for having lesser side effects than the synthetic counterparts. Here, we have investigated for the first time the therapeutic ... ...

    Abstract Purpose: Research on plant-based formulations has drawn considerable attention in the management of diabetic neuropathy (DN) for having lesser side effects than the synthetic counterparts. Here, we have investigated for the first time the therapeutic effects of a standardized
    Methods: Type 2 diabetes was induced in male Wistar rats using high fat diet and a single dose of streptozotocin (60 mg/kg
    Results: Viphyllin treatment markedly improved the body weight and glucose tolerance in diabetic rats. Also, the extract could significantly reduce the diabetes-induced elevation in FBG, liver and kidney indices. Further, Viphyllin dose-dependently increased the nociception latency in tail flick test compared to untreated diabetic rats (
    Conclusion: The study concludes that Viphyllin exerts antidiabetic effects and improves nerve conduction to mitigate neuropathic pain.
    Sprache Englisch
    Erscheinungsdatum 2022-06-15
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S366609
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Molecular docking analysis of Withaferin A from Withania somnifera with the Glucose regulated protein 78 (GRP78) receptor and the SARS-CoV-2 main protease

    Sudeep, H V / Gouthamchandra, K / Shyamprasad, K

    Bioinformation

    Abstract: Design and development of an effective compound to combat COVID-19 is clearly critical in the current circumstances. Therefore, it is of interest to document the molecular docking analysis data of the cellular receptor Glucose regulated protein 78 (GRP78) ...

    Abstract Design and development of an effective compound to combat COVID-19 is clearly critical in the current circumstances. Therefore, it is of interest to document the molecular docking analysis data of the cellular receptor Glucose regulated protein 78 (GRP78) with Withaferin A from Withania somnifera in the context of COVID-19 pandemic for further consideration. Here, we report the optimal interaction features of withaferin A, artemisinin, curcumin and andrographolide with the GRP78 receptor having low binding energies (-8.7, -7.89, -6.21 and -6.17 kcal/mol respectively) in this report. In order to gain additional insights, the interaction pattern of compounds with SARS-CoV-2 main protease (Mpro) was studied.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #729743
    Datenquelle COVID19

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  7. Artikel: Oral and Topical Administration of a Standardized Saw Palmetto Oil Reduces Hair Fall and Improves the Hair Growth in Androgenetic Alopecia Subjects - A 16-Week Randomized, Placebo-Controlled Study.

    Sudeep, Heggar Venkataramana / Rashmi, Sriram / Jestin, Thomas V / Richards, Aleksander / Gouthamchandra, Kuluvar / Shyamprasad, Kodimule

    Clinical, cosmetic and investigational dermatology

    2023  Band 16, Seite(n) 3251–3266

    Abstract: Purpose: Androgenetic alopecia (AGA) is the most common type of hair loss in humans, affecting self-esteem and emotional well-being. This study aimed to assess the safety and efficacy of VISPO: Methods: In a double-blind, placebo-controlled, four-arm ...

    Abstract Purpose: Androgenetic alopecia (AGA) is the most common type of hair loss in humans, affecting self-esteem and emotional well-being. This study aimed to assess the safety and efficacy of VISPO
    Methods: In a double-blind, placebo-controlled, four-arm clinical study, 80 healthy male and female subjects aged 18-50 years were randomly allocated (1:1:1:1) to receive either 400 mg capsules of VISPO or 5 mL of a topical formulation containing 20% VISPO or the respective placebo once daily for 16 weeks. The primary endpoints included hair count (hair comb and hair pull tests) and the self-assessment of perceived efficacy. Objective evaluation was performed using the global photographic assessment score. Hair density, thickness, and anagen/telogen ratio were evaluated using phototrichogram analysis.
    Results: At the end of the study, oral and topical formulations of VISPO reduced hair fall by up to 29% (
    Conclusion: VISPO formulations reduced hair fall and promoted hair regrowth and scalp appearance in AGA patients.
    Sprache Englisch
    Erscheinungsdatum 2023-11-11
    Erscheinungsland New Zealand
    Dokumenttyp Case Reports ; Clinical Trial
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S435795
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  8. Artikel ; Online: Aframomum melegueta

    Sudeep, Heggar Venkataramana / Aman, Khanna / Jestin, Thomas V / Shyamprasad, Kodimule

    Drug design, development and therapy

    2022  Band 16, Seite(n) 3777–3791

    Abstract: Purpose: Aframomum melegueta: Methods: In a double-blind, placebo-controlled clinical trial design, we have examined the thermogenic effects of a standardized : Results: Consumption of AfperFit significantly increased the energy expenditure (: ... ...

    Abstract Purpose: Aframomum melegueta
    Methods: In a double-blind, placebo-controlled clinical trial design, we have examined the thermogenic effects of a standardized
    Results: Consumption of AfperFit significantly increased the energy expenditure (
    Conclusion: Overall, this study validates the health benefits of
    Mesh-Begriff(e) Adult ; Male ; Female ; Humans ; Overweight/drug therapy ; Overweight/metabolism ; Intra-Abdominal Fat/metabolism ; Quality of Life ; Zingiberaceae/chemistry ; Energy Metabolism ; Double-Blind Method ; Seeds ; Plant Extracts
    Chemische Substanzen 6-paradol (BO24ID7E9U) ; Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2022-10-28
    Erscheinungsland New Zealand
    Dokumenttyp Randomized Controlled Trial ; Case Reports ; Clinical Trial
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S367350
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A standardized extract of

    Sudeep, Heggar Venkataramana / Gouthamchandra, Kuluvar / Ramanaiah, Illuri / Raj, Amritha / Naveen, Puttaswamy / Shyamprasad, Kodimule

    Pharmaceutical biology

    2023  Band 61, Heft 1, Seite(n) 1211–1221

    Abstract: Context: Preparations of : Objective: In this study, : Materials and methods: The standardized hydroalcoholic extract (4% chicoric acid) was prepared from the aerial parts of : Results: The SEP extract inhibited DPPH (IC50 = 106.7 µg/mL), ABTS!# ...

    Abstract Context: Preparations of
    Objective: In this study,
    Materials and methods: The standardized hydroalcoholic extract (4% chicoric acid) was prepared from the aerial parts of
    Results: The SEP extract inhibited DPPH (IC50 = 106.7 µg/mL), ABTS
    Conclusion: Our results strongly support SEP extract with 4% chicoric acid as a functional ingredient for immunomodulation.
    Mesh-Begriff(e) Mice ; Male ; Animals ; Echinacea/chemistry ; Nitric Oxide ; Cytokines ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Macrophages ; Immunosuppression Therapy ; Immunity
    Chemische Substanzen chicoric acid (S4YY3V8YHD) ; Nitric Oxide (31C4KY9ESH) ; Cytokines ; Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2023-08-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2023.2244000
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Kinetics and computational analysis of cholinesterase inhibition by REVERC3, a bisdemethoxycurcumin-rich extract

    Sudeep HV / Amritha Raj / Gouthamchandra K / Chandrappa S / Shyamprasad K

    SAGE Open Medicine, Vol

    Relevance to the treatment of Alzheimer’s disease

    2020  Band 8

    Abstract: Objectives: Cholinesterase inhibition is a common strategy to treat Alzheimer’s disease. In this study, we have investigated the cholinesterase inhibitory effects of a first-of-its-kind turmeric extract (REVERC3) having enriched content of ... ...

    Abstract Objectives: Cholinesterase inhibition is a common strategy to treat Alzheimer’s disease. In this study, we have investigated the cholinesterase inhibitory effects of a first-of-its-kind turmeric extract (REVERC3) having enriched content of bisdemethoxycurcumin as major active curcuminoid. Methods : The inhibition studies were performed using Ellman’s colorimetric assay. The kinetics of acetylcholinesterase and butyrylcholinesterase was determined in the presence of REVERC3 using the Lineweaver–Burk double reciprocal plots. Furthermore, we used AutoDock tools to predict the binding of bisdemethoxycurcumin with the active sites of cholinesterases. Results : REVERC3 showed 4.8- and 5.39-fold higher inhibitory potential of acetylcholinesterase and butyrylcholinesterase with IC50 values of 29.08 and 33.59 µg/mL, respectively, compared to the regular turmeric extract. The mode of binding of REVERC3 was competitive in the case of acetylcholinesterase while it was uncompetitive for the inhibition of butyrylcholinesterase. Docking analysis revealed that bisdemethoxycurcumin, the major constituent of REVERC3, has different preferences of binding in the active sites of acetylcholinesterase and butyrylcholinesterase. However, the best binding pose predictions are in line with the experimental binding mode of the cholinesterases. Conclusion : These results indicate that bisdemethoxycurcumin-enriched turmeric extract could improve the cholinergic functions via dual inhibition of cholinesterases. However, the predominant role of bisdemethoxycurcumin in REVERC3 must be further validated using preclinical studies and clinical trials.
    Schlagwörter Medicine (General) ; R5-920
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2020-11-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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