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  1. AU="Zhou, Long" AU="Zhou, Long"
  2. AU=Bauer Michael AU=Bauer Michael
  3. AU=Clapp Benjamin
  4. AU="Makarenko, V"
  5. AU="Stahl, Anna"
  6. AU="Wa, Qingbo"
  7. AU="Annette T. Byrne"
  8. AU="Godwin Oligbu"

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  1. Buch ; Online: Urban and Regional Cooperation and Development

    Zhou, Long / Li, Bin / Li, Sihong / Lei, Ngan Leng / Cheong, Kengfong

    Challenges and Strategies for the Planning and Development of the Guangdong–Macao Intensive Cooperation Zone in Hengqin Island

    (SpringerBriefs in Geography)

    2023  

    Verfasserangabe by Long Zhou, Bin Li, Sihong Li, Ngan Leng Lei, Kengfong Cheong
    Serientitel SpringerBriefs in Geography
    Schlagwörter Human geography ; Geography ; Urban economics
    Thema/Rubrik (Code) 304.2
    Sprache Englisch
    Umfang 1 Online-Ressource (IX, 94 p. 30 illus., 29 illus. in color)
    Ausgabenhinweis 1st ed. 2023
    Verlag Springer Nature Singapore ; Imprint: Springer
    Erscheinungsort Singapore
    Dokumenttyp Buch ; Online
    HBZ-ID HT021626151
    ISBN 978-981-19-8061-9 ; 9789811980602 ; 9789811980626 ; 9789811980633 ; 981-19-8061-6 ; 9811980608 ; 9811980624 ; 9811980632
    DOI 10.1007/978-981-19-8061-9
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Online: Urban and Regional Cooperation and Development

    Zhou, Long / Li, Bin / Li, Sihong / Lei, Ngan Leng / Cheong, Kengfong

    Challenges and Strategies for the Planning and Development of the Guangdong-Macao Intensive Cooperation Zone in Hengqin Island

    (SpringerBriefs in Geography)

    2023  

    Serientitel SpringerBriefs in Geography
    Schlagwörter Human geography ; Geography ; Urban economics ; Regional Cooperation ; Regional Planning and Development ; Collaborative Urban Development ; Sustainable Cities ; Hengqin Guangdong-Macao Intensive Cooperation Zone ; City Cluster ; Urban Planning ; Urban Studies ; Regional Research ; Cross Border Cooperation
    Sprache Englisch
    Umfang 1 electronic resource (94 pages)
    Verlag Springer Nature
    Erscheinungsort Singapore
    Dokumenttyp Buch ; Online
    Anmerkung English
    HBZ-ID HT030379934
    ISBN 9789811980619 ; 9811980616
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Artikel ; Online: Association of statin use with osteoporosis risk: a drug-targeted Mendelian randomization study.

    Ren, Zhaozhou / Zhou, Long

    Inflammopharmacology

    2024  Band 32, Heft 2, Seite(n) 1253–1261

    Abstract: Background: Hypercholesterolemia and the related inflammatory response promote the development of osteoporosis, but whether targeted interventions are protective against this bone metabolic disease remains unknown. The aim of this study was to ... ...

    Abstract Background: Hypercholesterolemia and the related inflammatory response promote the development of osteoporosis, but whether targeted interventions are protective against this bone metabolic disease remains unknown. The aim of this study was to investigate the association between the use of statins (one well-recognized cholesterol-lowering drug with anti-inflammatory properties) and the risk of osteoporosis using a drug-targeted Mendelian randomization (MR) approach.
    Methods: Instrumental variables predicting three cholesterol-lowering target genes (including HGMCR) and the cholesterol effectors mediated by these genes (i.e., total cholesterol, LDL cholesterol, and non-HDL cholesterol) were extracted from expression quantitative trait loci and genome-wide association studies. Inverse variance-weighted (IVW), summary data-based MR (SMR), multivariate MR, and colocalization analysis were used to determine the association of the interventions represented by these instrumental variables with heel bone mineral density (one diagnostic indicator of osteoporosis).
    Results: The IVW reported that increased levels of HGMCR-mediated total cholesterol, LDL cholesterol, and non-HDL cholesterol were associated with the decreased level of heel bone mineral density (P = 4.086e-10, P = 1.487e-09, P = 1.967e-09). The colocalization analysis supported the relationship between HGMCR-mediated non-HDL cholesterol and heel bone mineral density. The SMR reported that higher expression of HGMCR was associated with the decreased level of this osteoporosis indicator (P = 0.036). The multivariate MR further confirmed the role of HGMCR in the correlation between cholesterol traits and heel bone mineral density, and also reported that estrogen played a mediating role in the above correlations.
    Conclusion: These evidence supported a protective effect of HMGCR-mediated non-HDL cholesterol reduction or statin use against osteoporosis.
    Mesh-Begriff(e) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Cholesterol, LDL ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Osteoporosis/drug therapy ; Osteoporosis/genetics ; Polymorphism, Single Nucleotide
    Chemische Substanzen Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol, LDL
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-024-01441-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Numerical study on fiber waviness defect and sensitivity analysis of the parameters

    Zhou Long / Zhu Shuhua

    E3S Web of Conferences, Vol 360, p

    2022  Band 01084

    Abstract: The presence of fiber waviness defects is well-known to reduce the compressive strength. A FE model was established and the results of failure load and mode were compared with the test results to demonstrate the validity and accuracy. The influence of ... ...

    Abstract The presence of fiber waviness defects is well-known to reduce the compressive strength. A FE model was established and the results of failure load and mode were compared with the test results to demonstrate the validity and accuracy. The influence of two parameters L and offset Angle θ of fiber waviness defect was studied. The simulation results show that the compression failure load increases with the increasing of L at constant A/H for convex and concave fiber fold by 33.0% and 20.1% respectively, but there is no significant effect on the failure load with θ within 5%.
    Schlagwörter Environmental sciences ; GE1-350
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag EDP Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Construction of a Ceramic Appearance Design System Based on Technology for Internet of Things

    Zhou Long / Junzhe Ouyang

    Computational Intelligence and Neuroscience, Vol

    2022  Band 2022

    Abstract: The planning and design of intelligent storage systems in ceramic parks based on the industrial Internet of Things technology are proposed. Based on the analysis of the storage demand of ceramic parks, information transformation is carried out according ... ...

    Abstract The planning and design of intelligent storage systems in ceramic parks based on the industrial Internet of Things technology are proposed. Based on the analysis of the storage demand of ceramic parks, information transformation is carried out according to the original manual operation mode. The RFID technology is applied to the overall planning of the warehouse area and the deployment of the software; it is applied to the overall planning of the RFID system, the hardware deployment of the two-dimensional warehouse system, and the integration of the RFID technology and the software deployment of the two-dimensional warehouse system. It realizes the close cooperation between the information system and hardware equipment, optimizes the system process, and improves the level of warehouse management.In addition, smart terminal ceramics refer to those with fine ceramic appearances or functionalities in smart terminal products, such as smartphones, smart watches, and other wearable devices, in the field of consumer electronics, including ceramic back plates, middle frames, buttons, fingerprint recognition sheets on mobile phones and ceramic cases, bracelets, and back covers on smart watches. Aside the excellent performance and aesthetic properties of ceramic materials, they can also be adapted to the trends in 5G and wireless communication technology. From the perspective of high strength, high toughness, and colorful nano-zirconia ceramics, this article was aimed to review the development process and industrialization application process.
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
    Thema/Rubrik (Code) 600
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Helicobacter pylori infection induces POU5F1 upregulation and SPP1 activation to promote chemoresistance and T cell inactivation in gastric cancer cells.

    Song, Hanyi / Yao, Xinjie / Zheng, Yuqi / Zhou, Long

    Biochemical pharmacology

    2024  Band 225, Seite(n) 116253

    Abstract: Infection with Helicobacter pylori (H. pylori or Hp) is associated with an increased susceptibility to gastric diseases, notably gastric cancer (GC). This study investigates the impact of Hp infection on chemoresistance and immune activity in GC cells. ... ...

    Abstract Infection with Helicobacter pylori (H. pylori or Hp) is associated with an increased susceptibility to gastric diseases, notably gastric cancer (GC). This study investigates the impact of Hp infection on chemoresistance and immune activity in GC cells. Hp infection in AGS and MKN-74 cells promoted proliferation, migration and invasion, apoptosis resistance, and tumorigenic activity of cells under cisplatin (DDP) plus gemcitabine (GEM) treatment. Additionally, it dampened activity of the co-cultured CD8
    Sprache Englisch
    Erscheinungsdatum 2024-05-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116253
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 19: Hefte anzeigen Standort:
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  7. Artikel ; Online: Association of serum 25-hydroxyvitamin D concentrations with all-cause and cardiovascular mortality among US adults with prehypertension: a prospective cohort study.

    Zhou, Yongmei / Chen, Yu / Chen, Fuli / Li, Gang / Zhou, Long

    Journal of health, population, and nutrition

    2024  Band 43, Heft 1, Seite(n) 24

    Abstract: Background: Prehypertension affects 25-50% of adults worldwide and no prior study has examined the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentrations and mortality risk in individuals with prehypertension. This study aims to ... ...

    Abstract Background: Prehypertension affects 25-50% of adults worldwide and no prior study has examined the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentrations and mortality risk in individuals with prehypertension. This study aims to investigate the association of serum 25(OH)D concentrations with all-cause and CVD mortality among prehypertensive adults by utilizing data from the US National Health and Nutrition Examination Survey (NHANES) 2007-2014 and linked 2019 mortality file.
    Methods: We included 4345 prehypertensive adults who participated in the NHANES between 2007 and 2014 and were followed up until 31 December 2019. Weighted Cox proportional hazards models were used with adjustments for multiple covariates to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the risks of dying from any cause and CVD.
    Results: During a median follow-up of 8.8 years, 335 deaths from any causes were documented, of which 88 participants died from CVD. Compared with participants with sufficient 25(OH)D (≥ 75 nmol/L), the multivariate-adjusted HRs and 95% CIs for participants with severe deficiency (< 25 nmol/L), moderate deficiency (25-49.9 nmol/L), and insufficient concentrations (50-74.9 nmol/L) of serum 25(OH)D for all-cause death were 2.83 (1.46-5.52), 1.17 (0.74-1.86), and 1.36 (0.93-1.98), respectively. Similarly, the multivariable-adjusted HRs and 95%CIs for CVD death were 4.14 (1.10-15.51), 1.23 (0.46-3.28), and 1.73 (0.96-3.14), respectively. We found that there was a 9% reduction in the risk of death from all causes and a 14% reduction in the risk of death from CVD for every 10 nmol/L increase in serum 25(OH)D concentrations.
    Conclusion: Severe serum 25(OH)D deficiency among prehypertensive adults was associated with increased risk of mortality from all causes as well as from CVD. Our work suggests that supplementing with vitamin D may prevent premature death in severely deficient individuals with prehypertension.
    Mesh-Begriff(e) Adult ; Humans ; Nutrition Surveys ; Cardiovascular Diseases ; Vitamin D Deficiency ; Prospective Studies ; Prehypertension ; Vitamin D ; Calcifediol ; Risk Factors
    Chemische Substanzen 25-hydroxyvitamin D (A288AR3C9H) ; Vitamin D (1406-16-2) ; Calcifediol (P6YZ13C99Q)
    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland Bangladesh
    Dokumenttyp Journal Article
    ZDB-ID 2025045-9
    ISSN 2072-1315 ; 1606-0997
    ISSN (online) 2072-1315
    ISSN 1606-0997
    DOI 10.1186/s41043-024-00515-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Aspirin versus low-molecular-weight heparin for thromboprophylaxis after orthopaedic surgery: a systematic review and meta-analysis.

    Wu, Haichao / Zhou, Long / Wang, Qiang / Wang, Tao / Liang, Siyuan

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

    2024  Band 35, Heft 4, Seite(n) 187–195

    Abstract: The article aimed to compare the efficiency and safety of aspirin with low-molecular-weight heparin (LMWH) for thromboprophylaxis in orthopaedic surgery patients. According to the inclusion and exclusion criteria, PubMed, Embase and Cochrane Library ... ...

    Abstract The article aimed to compare the efficiency and safety of aspirin with low-molecular-weight heparin (LMWH) for thromboprophylaxis in orthopaedic surgery patients. According to the inclusion and exclusion criteria, PubMed, Embase and Cochrane Library database were searched for studies comparing aspirin and LMWH in venous thromboembolism (VTE) prophylaxis until 25 April 2023. The outcome measures included deep venous thrombosis(DVT)/Pulmonary embolism(PE) events, major bleeding events, wound complications, wound infection and death. Six studies met the requirements of our meta-analysis, including 12 470 patients in the aspirin group and 10 857 patients in the LMWH group. The meta-analysis showed that results showed that LMWH was superior to aspirin in preventing VTE events (odds ratio (OR) 1.44, 95% CI 1.24-1.68, P  < 0.00001), whereas there was no significant difference between them in bleeding events (OR 0.95, 95% CI 0.86-1.05, P  = 0.33), wound complication (OR 0.58, 95% CI 0.28-1.17, P  = 0.13), wound infection (OR 1.12, 95% CI 0.86-1.47, P  = 0.39) and mortality (OR 1.04, 95% CI 0.70-1.55, P  = 0.83). In addition, subgroup analysis showed that compared with aspirin, LMWH was more likely to reduce the incidence of DVT events in orthopaedic surgery patients (OR 1.59, 95% CI 1.33-1.91, P  < 0.00001), whereas there was no advantage in reducing the incidence of PE events (OR 1.22, 95% CI 0.62-2.40, P  = 0.56). Despite the similar safety profiles, this meta-analysis showed that LMWH was significantly superior to aspirin in thromboprophylaxis after orthopaedic surgery. LMWH was still the first-line drug for thrombosis prevention in patients who underwent major orthopaedic surgeries.
    Mesh-Begriff(e) Humans ; Heparin, Low-Molecular-Weight/therapeutic use ; Aspirin/therapeutic use ; Aspirin/adverse effects ; Orthopedic Procedures/adverse effects ; Venous Thromboembolism/prevention & control ; Venous Thromboembolism/etiology ; Anticoagulants/therapeutic use ; Pulmonary Embolism/prevention & control ; Pulmonary Embolism/etiology ; Venous Thrombosis/prevention & control ; Venous Thrombosis/etiology ; Postoperative Complications/prevention & control
    Chemische Substanzen Heparin, Low-Molecular-Weight ; Aspirin (R16CO5Y76E) ; Anticoagulants
    Sprache Englisch
    Erscheinungsdatum 2024-04-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Systematic Review ; Meta-Analysis
    ZDB-ID 1033551-1
    ISSN 1473-5733 ; 0957-5235
    ISSN (online) 1473-5733
    ISSN 0957-5235
    DOI 10.1097/MBC.0000000000001300
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2920: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Artikel ; Online: Inhibition of Liver Cancer Cell Viability by Triazole through Up-regulation of p38 Phosphorylation and Targeting the Activation of p-ERK1/2 and Akt Protein Expression.

    Shanfeng Li / Zhou, Long / Zhao, Feng / Wang, Haisong / Sun, Meng

    Doklady. Biochemistry and biophysics

    2024  Band 516, Heft 1, Seite(n) 66–72

    Abstract: The present study was aimed to explore the effect of triazole on growth and viability of liver cancer cells. Cell growth was examined using the MTT test and expression of several proteins was assessed by western blotting assay. The Matrigel-coated ... ...

    Abstract The present study was aimed to explore the effect of triazole on growth and viability of liver cancer cells. Cell growth was examined using the MTT test and expression of several proteins was assessed by western blotting assay. The Matrigel-coated Transwell assay was employed to examine the infiltration of cells. The data from MTT assay showed that MHCC97H and H4TG liver cancer cell viability was inhibited by triazole in a concentration-dependent manner. After treatment with 0.5, 1.0, 2.0, 4, 8, and 16 µM doses of triazole, the rate of H4TG cell viability was decreased to 96, 73, 58, 39, 29, and 28%, respectively. Treatment of MHCC97H cells with 0.5, 1.0, 2.0, 4, 8, and 16 µM doses of triazole resulted in a reduction in cell viability to 94, 70, 53, 35, 22, and 21%, respectively. Triazole treatment also led to a significant reduction in MHCC97H cell invasiveness compared to the control cells. In MHCC97H cells treated with triazole, there was a noticeable decrease in the levels of p-ERK1/2, and p-Akt protein expression. Treatment of MHCC97H cells with triazole resulted in a prominent increase in p-p38 level. In summary, triazole inhibits growth and viability of liver cancer cells through targeting the activation of p-ERK1/2 and Akt proteins. Therefore, triazole may be investigated further as a therapeutic agent for the treatment of liver cancer.
    Mesh-Begriff(e) Humans ; Triazoles/pharmacology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Cell Survival/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphorylation/drug effects ; Cell Line, Tumor ; p38 Mitogen-Activated Protein Kinases/metabolism ; Up-Regulation/drug effects ; Mitogen-Activated Protein Kinase 3/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Cell Proliferation/drug effects ; MAP Kinase Signaling System/drug effects ; Antineoplastic Agents/pharmacology
    Chemische Substanzen Triazoles ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2024-05-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2062390-2
    ISSN 1608-3091 ; 1607-6729
    ISSN (online) 1608-3091
    ISSN 1607-6729
    DOI 10.1134/S1607672923600525
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  10. Artikel ; Online: Sophorolipid modification enables high reactivity and electron selectivity of nanoscale zerovalent iron toward hexavalent chromium

    Zhou, Long / Wang, Guang / Yi, Yunqiang / Fang, Zhanqiang

    Journal of Environmental Management. 2023 Jan., v. 326 p.116775-

    2023  

    Abstract: Nanoscale zero-valent iron is considered to be a promising nanostructure for environmental remediation, while increasing the electron selectivity of nanoscale zerovalent iron (nZVI) during target contaminant removal is still a challenge (electron ... ...

    Abstract Nanoscale zero-valent iron is considered to be a promising nanostructure for environmental remediation, while increasing the electron selectivity of nanoscale zerovalent iron (nZVI) during target contaminant removal is still a challenge (electron selectivity, defined as the percentage of electrons transferred to the target contaminants over the number of electrons donated by nZVI). In this study, the strategy for increasing the reactivity and electron selectivity of nZVI via sophorolipid (SL-nZVI) modification was proposed. The results showed that the removal efficiency and electron selectivity of SL-nZVI toward Cr(VI) was 99.99% and 56.30%, which was higher than that of nZVI (61.16%, 25.91%). Meanwhile, the particles were well characterized and the mechanism for enhanced reactivity and electron selectivity was investigated. Specially, both the morphology and BET specific surface area characterization suggested that stability against aggregation was higher in SL-nZVI nanoparticles than in nZVI. Besides, X-ray photoelectron spectroscopy (XPS), Tafel polarization curves, and Electrochemical impedance spectroscopy also indicated that the introduction of sophorolipid successfully prevent the nanoparticles from oxidation and benefit the electron transferring. In addition, a water contact angle test revealed that SL-nZVI nanoparticles were less hydrophilic (contact angle = 34.8°) than nZVI (contact angle = 23.9°). Therefore, in terms of reactivity, sophorolipid modification inhibited the aggregation of the nanoparticles and enhanced the electrical conductivity. For electron selectivity, the introduction of sophorolipid not only benefited Cr(VI) adsorption and the electron transfer from Fe⁰ to the surface-adsorbed Cr(VI) that followed but also reduced the possibility of side reactions between Fe⁰ and H₂O. This study demonstrates that the introduction of sophorolipid is an effective strategy for developing a highly efficient nZVI-based nanocomposite system and highlights the potential role of sophorolipid in improving the electron selectivity of nZVI.
    Schlagwörter X-ray photoelectron spectroscopy ; adsorption ; chromium ; contact angle ; dielectric spectroscopy ; electrical conductivity ; electron transfer ; hydrophilicity ; iron ; nanocomposites ; nanoparticles ; oxidation ; remediation ; surface area ; Sophorolipid ; nZVI ; Cr(VI) ; Electron selectivity ; Mechanism
    Sprache Englisch
    Erscheinungsverlauf 2023-01
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2022.116775
    Datenquelle NAL Katalog (AGRICOLA)

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