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  1. Artikel ; Online: Gut Microbiota Association with Diverticular Disease Pathogenesis and Progression: A Systematic Review.

    Reitano, Elisa / Francone, Elisa / Bona, Elisa / Follenzi, Antonia / Gentilli, Sergio

    Digestive diseases and sciences

    2022  Band 68, Heft 3, Seite(n) 913–921

    Abstract: Introduction: Growing evidence supports the role of the intestinal microbiome in the development of different intestinal and extraintestinal diseases. Diverticular disease (DD) is one of the most common disorders in western countries. In the last years, ...

    Abstract Introduction: Growing evidence supports the role of the intestinal microbiome in the development of different intestinal and extraintestinal diseases. Diverticular disease (DD) is one of the most common disorders in western countries. In the last years, different articles have suggested a possible role of the intestinal microbiome in DD pathogenesis and in the development of acute diverticulitis (AD). This systematic review aimed to clarify the current knowledge on the role of the intestinal microbiome in colonic diverticulitis in different stages according to the 2009 PRISMA guidelines.
    Materials and methods: Two independent reviewers searched the literature in a systematic manner through online databases, including Medline, Scopus, Embase, Cochrane Oral Health Group Specialized Register, ProQuest Dissertations and Theses Database, and Google Scholar. Patients with any stage of disease were included. The Newcastle-Ottawa scale for case-control and cohort studies was used for the quality assessment of the selected articles.
    Results: Overall, nine studies were included in the review. Only one article was focused on patients with AD, while all other articles only considered patients with DD without acute inflammation signs. Enterobacteriaceae seems to be the microbiota most associated with the disease, followed by Bifidobacteria.
    Conclusions: All the included studies showed great heterogeneity in population characteristics and sampling methods. Therefore, given the high prevalence of colonic diverticulitis in the general population, further studies are needed to clarify the role of the intestinal microbiome, paving the way to new target therapies with important social implications.
    Mesh-Begriff(e) Humans ; Diverticulitis, Colonic ; Gastrointestinal Microbiome ; Diverticular Diseases/etiology ; Diverticulitis/epidemiology ; Intestines
    Sprache Englisch
    Erscheinungsdatum 2022-07-07
    Erscheinungsland United States
    Dokumenttyp Systematic Review ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-022-07600-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Colorectal surgery in elderly patients: our experience with DaVinci Xi® System.

    Oldani, A / Bellora, P / Monni, M / Amato, B / Gentilli, S

    Aging clinical and experimental research

    2017  Band 29, Heft Suppl 1, Seite(n) 91–99

    Abstract: Background: Robotic technology for colorectal surgery was introduced by Weber in 2002 to improve the benefits of the minimally invasive surgery already offered by the laparoscopic approach.: Aims: To evaluate the feasibility and the efficacy of the ... ...

    Abstract Background: Robotic technology for colorectal surgery was introduced by Weber in 2002 to improve the benefits of the minimally invasive surgery already offered by the laparoscopic approach.
    Aims: To evaluate the feasibility and the efficacy of the application of robotic surgery in elderly patients affected by colorectal diseases.
    Methods: We reported the outcomes obtained during our first 50 colorectal robotic surgical performances with DaVinci Xi® System, and we compared the results assessed for patients younger or older than 70 years.
    Results: We examined 28 patients younger and 22 older than 70 years who underwent colorectal robotic surgery in our institution from September 2014 to June 2016. We performed 15 right colectomies, 20 left colectomies, 15 rectal resections. Mean ASA score was significantly higher in the Elderly Group. No statistically significant differences have been revealed in terms of post-operative morbidity, hospital stay, first diet intake, first flatus canalization and oncological outcome.
    Discussion: According to the prolonged operative time, robotic technology was initially reserved to young patients with good performance status in order to avoid systemic failures in elderly patients suffering from pre-existent comorbidities. Otherwise, once robotic approach safety and benefits in terms of better systemic outcomes were demonstrated, it started to be performed in elderly patients with satisfactory outcomes.
    Conclusion: Our experience revealed that robotic surgical approach is safe, feasible and offers many systemic benefits in elderly patients also with high ASA score. Age alone has not to be considered as exclusion criteria for robotic approach.
    Mesh-Begriff(e) Aged ; Colectomy/adverse effects ; Colectomy/methods ; Colorectal Neoplasms/surgery ; Feasibility Studies ; Female ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Length of Stay ; Male ; Operative Time ; Outcome and Process Assessment (Health Care) ; Risk Adjustment ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/instrumentation ; Robotic Surgical Procedures/methods
    Sprache Englisch
    Erscheinungsdatum 2017-02
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-016-0670-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: A rare case of Calot's triangle paraganglioma

    Oldani, A. / Boldorini, R. / Spina, P. / Gentilli, S.

    European surgery

    2017  Band 49, Heft 5, Seite(n) 244

    Sprache Englisch ; Deutsch
    Dokumenttyp Artikel
    ZDB-ID 2073941-2
    ISSN 1682-8631 ; 1682-1769
    Datenquelle Current Contents Medizin

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  4. Artikel ; Online: MicroRNAs differential expression profile in metastatic colorectal cancer: A pilot study with literature review.

    Francone, Elisa / Gentilli, Sergio / Santori, Gregorio / Stabilini, Cesare / Fornaro, Rosario / Frascio, Marco

    Surgical oncology

    2021  Band 37, Seite(n) 101524

    Abstract: Background and objectives: Colorectal cancer is still one of the leading causes of cancer-related deaths worldwide and specific tools to improve disease assessment and treatment response are advocated. The aim of this study was to analyze miRNAs ... ...

    Abstract Background and objectives: Colorectal cancer is still one of the leading causes of cancer-related deaths worldwide and specific tools to improve disease assessment and treatment response are advocated. The aim of this study was to analyze miRNAs expression in metastatic and non-metastatic colorectal cancer, in order to identify reliable biomarkers suitable for prognosis, treatment and patient's monitoring.
    Material and methods: Among 25 patients (mean age 71 ± 12 years; Female/Male: 12/13) submitted to laparoscopic colorectal resection between August 2017 and February 2019, miRNAs were extracted from fresh frozen tissues of solid tumors. Gene expression's analysis arising from microarray technology was performed.
    Results: Pathological evaluation identified 15 metastatic patients (8 presenting with stage III and 7 with stage IV cancers) and 10 non-metastatic patients (4 presenting with stage I and 6 stage II cancers). Bioinformatic analysis of solid biopsies revealed 16 miRNAs (11 upregulated and 5 downregulated) differently expressed between metastatic and non-metastatic groups, with three miRNAs (miR-7515, miR-7109-5p and miR-6831-5p) never linked to colorectal cancer before.
    Conclusions: Our study showed an association between miRNAs and metastatic colorectal cancer, suggesting their potential role as biomarkers for tumor management, if confirmed by further studies.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Female ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Metastasis/genetics ; Neoplasm Metastasis/pathology ; Pilot Projects ; Prospective Studies
    Chemische Substanzen Biomarkers, Tumor ; MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2021-01-31
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1107810-8
    ISSN 1879-3320 ; 0960-7404
    ISSN (online) 1879-3320
    ISSN 0960-7404
    DOI 10.1016/j.suronc.2021.101524
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Butyrate Inhibits Colorectal Cancer Cell Proliferation through Autophagy Degradation of β-Catenin Regardless of

    Garavaglia, Beatrice / Vallino, Letizia / Ferraresi, Alessandra / Esposito, Andrea / Salwa, Amreen / Vidoni, Chiara / Gentilli, Sergio / Isidoro, Ciro

    Biomedicines

    2022  Band 10, Heft 5

    Abstract: Colorectal cancer (CRC) pathogenesis is mainly driven by alterations in WNT signaling, which results in altered transcriptional activity of β-Catenin. Mutations ... ...

    Abstract Colorectal cancer (CRC) pathogenesis is mainly driven by alterations in WNT signaling, which results in altered transcriptional activity of β-Catenin. Mutations in
    Sprache Englisch
    Erscheinungsdatum 2022-05-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10051131
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Thin metallic thread in the gastrointestinal tract: an uncommon complication after coil embolization of a visceral pseudoaneurysm.

    Paladini, A / Guzzardi, G / Stanca, C / Del Sette, B / Tettoni, S / Negroni, D / Cernigliaro, M / Galbiati, A / Spinetta, M / Gentilli, S / Carriero, A

    Journal of biological regulators and homeostatic agents

    2020  Band 34, Heft 5, Seite(n) 1955–1957

    Mesh-Begriff(e) Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/therapy ; Embolization, Therapeutic/adverse effects ; Gastrointestinal Tract ; Humans ; Stents
    Sprache Englisch
    Erscheinungsdatum 2020-11-26
    Erscheinungsland Italy
    Dokumenttyp Letter
    ZDB-ID 639196-5
    ISSN 1724-6083 ; 0393-974X
    ISSN (online) 1724-6083
    ISSN 0393-974X
    DOI 10.23812/20-315-L
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Learning curve for laparoscopic cholecystectomy has not been defined: A systematic review.

    Reitano, Elisa / de'Angelis, Nicola / Schembari, Elena / Carrà, Maria Clotilde / Francone, Elisa / Gentilli, Sergio / La Greca, Gaetano

    ANZ journal of surgery

    2021  Band 91, Heft 9, Seite(n) E554–E560

    Abstract: Background: Laparoscopic cholecystectomy is one of the most performed surgeries worldwide but its learning curve is still unclear.: Methods: A systematic review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and ... ...

    Abstract Background: Laparoscopic cholecystectomy is one of the most performed surgeries worldwide but its learning curve is still unclear.
    Methods: A systematic review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Two independent reviewers searched the literature in a systematic manner through online databases, including Medline, Scopus, Embase, and Google Scholar. Human studies investigating the learning curve of laparoscopic cholecystectomy were included. The Newcastle-Ottawa scale for cohort studies and the GRADE scale were used for the quality assessment of the selected articles.
    Results: Nine cohort studies published between 1991 and 2020 were included. All studies showed a great heterogeneity among the considered variables. Seven articles (77.7%) assessed intraoperative variables only, without considering patient's characteristics, operator's experience, and grade of gallbladder inflammation. Only five articles (55%) provided a precise cut-off value to see proficiency in the learning curve, ranging from 13 to 200 laparoscopic cholecystectomies.
    Conclusions: The lack of clear guidelines when evaluating the learning curve in surgery, probably contributed to the divergent data and heterogeneous results among the studies. The development of guidelines for the investigation and reporting of a surgical learning curve would be helpful to obtain more objective and reliable data especially for common operation such as laparoscopic cholecystectomy.
    Mesh-Begriff(e) Cholecystectomy, Laparoscopic ; Humans ; Learning Curve
    Sprache Englisch
    Erscheinungsdatum 2021-06-28
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Review ; Systematic Review
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.17021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Ultrastructural analysis of different-made staplers' staples.

    Gentilli, S / Portigliotti, L / Surico, D / Milanesio, M / Gatti, G

    Techniques in coloproctology

    2013  Band 17, Heft 6, Seite(n) 683–685

    Mesh-Begriff(e) Microscopy, Electron, Scanning ; Sutures
    Sprache Englisch
    Erscheinungsdatum 2013-12
    Erscheinungsland Italy
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-012-0941-3
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  9. Artikel ; Online: Ileal endometriosis and Crohn's disease: an unusual association causing acute bowel obstruction.

    Oldani, Alberto / Monni, Manuela / Gentilli, Sergio

    Annali italiani di chirurgia

    2016  Band 87, Heft ePub

    Abstract: Aim: Endometriosis is a commun health disorder in women, which is defined as the presence of bowel endometrial-like tissue outside the uterus. Bowel endometriosis occurs in approximately10% pf all cases, with ileal localization as a very rare clinical ... ...

    Abstract Aim: Endometriosis is a commun health disorder in women, which is defined as the presence of bowel endometrial-like tissue outside the uterus. Bowel endometriosis occurs in approximately10% pf all cases, with ileal localization as a very rare clinical intestinal occlusion:acute intestinal obstruction is possible presentation of this disease. We report a case of a patient with known history of Crohn's treated with ileal resection for acute intestinal occlusion;histology showed the coexistence of IBD and endometriosis in the intestinal wall.
    Case report: A 35 years old female patient, with previous diagnosis of Crohn's disease confirmed by endoscopic biopsies, was admitted to our Institutions because oc acute intestinal obstruction. She previously suffered of dysmenorrhea and pelvic pain during menstration. A contrast enhanced CT abdominal scan was performed with evidence of diffuse small bowel fluid distension and thickening of terminal iileum wall, compatible with ilea stenosis in acute Crohn disease.
    Results: The patient underwent laparoscopic resection of distal ileus. Definitive histological examination showed ileal wall with multiple endometriosis foci and chronic follicular flogosis.
    Conclusion: The case that we have described shows a rare co-existence of the two clinical entitle (Crohn's disease and ileal deep endometriosis), histologically demonstrated, with acute presentation as intestinal obstruction, susseflully treated with laparoscopic ileal resection KEY WORDS Bowel obstruction, Crohn's disease, Endometriosis.
    Mesh-Begriff(e) Adult ; Crohn Disease/complications ; Diagnosis, Differential ; Endometriosis/complications ; Endometriosis/diagnosis ; Endometriosis/surgery ; Female ; Humans ; Ileum/surgery ; Intestinal Obstruction/diagnosis ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Laparoscopy ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2016-03-23
    Erscheinungsland Italy
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 418927-9
    ISSN 2239-253X ; 0003-469X
    ISSN (online) 2239-253X
    ISSN 0003-469X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Weight loss after laparoscopic sleeve gastrectomy: the 4-years experience at maggiore della carità hospital (novara, piedmont)

    Cerri, C. / Cava, E. / Butera, F. / Collo, A. / D'Aloisio, G. / Passera, S.A. / Albertazzi, E. / Capello, E.C. / Scotti, L. / Riso, S. / Gentilli, S.

    Nutrition. 2021 Aug., v. 87-88

    2021  

    Abstract: Bariatric surgery is currently considered the most effective longterm treatment to obtain substantial and sustained Weight Loss (WL) in severe and/or morbid obesity. We present data collected by a multi-disciplinary team between July 2016 and September ... ...

    Abstract Bariatric surgery is currently considered the most effective longterm treatment to obtain substantial and sustained Weight Loss (WL) in severe and/or morbid obesity. We present data collected by a multi-disciplinary team between July 2016 and September 2020 at “Maggiore Della Carità” University Hospital (Novara, Piedmont) concerning bariatric procedures performed according to international and national guidelines (1).Among 267 candidates, 92 (34,4%) subjects underwent a bariatric procedure. Laparoscopic Sleeve Gastrectomy (LSG) was performed in 66 (71.7%) subjects, including 4 anti-reflux valves. Other procedures included: 7 (10.6%) Roux-Y Gastric Bypass, 4 (6.1%) Endoscopic Gastric Plication, and 10 (15.2%) Laparoscopic Adjustable Gastric Banding Removal.Among LSG, 35 patients completed at least a 2-year follow-up after surgery: 27 (77.1%) females, 8 (22.9%) males, mean age 44,89 (± 10.1) years old. Table 1 shows significant variations from baseline (p<0.05) after 1, 6, 12, and 24 months observed for body weight, BMI, excess weight, waist circumference, and serum glucose levels. Among complications, no severe adverse events were recorded. Two gastric fistulas were successfully treated by endoscopy.In our multidisciplinary experience, LSG was effective to achieve and maintain a significant weight loss and to improve glucose levels up to 2 years after surgery. Larger cohorts and longer period data will provide further concerns in terms of maintenance, insulin resistance, and long-term metabolic complications decrease.
    Schlagwörter bariatric surgery ; blood glucose ; glucose ; hospitals ; insulin resistance ; nutrition ; obesity ; piedmont ; waist circumference ; weight loss
    Sprache Englisch
    Erscheinungsverlauf 2021-08
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2021.111322
    Datenquelle NAL Katalog (AGRICOLA)

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