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  1. Artikel ; Online: Facile process of

    Saha, Ishita / Ghosh, Sourav / Roy, Shubham / Basu, Tarakdas / Karmakar, Parimal

    Biomedical materials (Bristol, England)

    2024  Band 19, Heft 3

    Abstract: Mucilage is a sticky substance found in various plants and microorganisms and is made up of proteins and polysaccharides. Mucilage ... ...

    Abstract Mucilage is a sticky substance found in various plants and microorganisms and is made up of proteins and polysaccharides. Mucilage from
    Mesh-Begriff(e) Mice ; Animals ; Humans ; Wound Healing ; Rosa ; Plant Extracts/chemistry ; Bromodeoxyuridine ; Reactive Oxygen Species ; Burns/therapy ; Skin Diseases
    Chemische Substanzen Plant Extracts ; Bromodeoxyuridine (G34N38R2N1) ; Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2024-03-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2265222-X
    ISSN 1748-605X ; 1748-6041
    ISSN (online) 1748-605X
    ISSN 1748-6041
    DOI 10.1088/1748-605X/ad2c1d
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  2. Artikel ; Online: Corrigendum: Topical effect of polyherbal flowers extract on xanthan gum hydrogel patch-induced wound healing activity in human cell lines and male BALB/c mice (2023

    Saha, Ishita / Roy, Shubham / Das, Deepak / Das, Sukhen / Karmakar, Parimal

    Biomedical materials (Bristol, England)

    2023  Band 18, Heft 6

    Sprache Englisch
    Erscheinungsdatum 2023-09-15
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2265222-X
    ISSN 1748-605X ; 1748-6041
    ISSN (online) 1748-605X
    ISSN 1748-6041
    DOI 10.1088/1748-605X/acf663
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Topical effect of polyherbal flowers extract on xanthan gum hydrogel patch-induced wound healing activity in human cell lines and male BALB/c mice.

    Saha, Ishita / Roy, Shubham / Das, Deepak / Das, Sukhen / Karmakar, Parimal

    Biomedical materials (Bristol, England)

    2023  Band 18, Heft 3

    Abstract: Wound or injury is a breakdown in the skin's protective function as well as damage to the normal tissues. Wound healing is a dynamic and complex phenomenon of replacing injured skin or body tissues. In ancient times ... ...

    Abstract Wound or injury is a breakdown in the skin's protective function as well as damage to the normal tissues. Wound healing is a dynamic and complex phenomenon of replacing injured skin or body tissues. In ancient times the
    Mesh-Begriff(e) Animals ; Mice ; Humans ; Male ; Hydrogels/chemistry ; Wound Healing ; Cell Line ; Plants, Medicinal ; Flowers ; Plant Extracts/chemistry
    Chemische Substanzen Hydrogels ; xanthan gum (TTV12P4NEE) ; Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2023-05-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265222-X
    ISSN 1748-605X ; 1748-6041
    ISSN (online) 1748-605X
    ISSN 1748-6041
    DOI 10.1088/1748-605X/acce89
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  4. Artikel ; Online: Contrasting effects of molecular crowding on the membrane-perturbing and chaperone-like activities of major bovine seminal plasma protein, PDC-109.

    Singh, Bhanu Pratap / Cheppali, Sudheer K / Saha, Ishita / Swamy, Musti J

    International journal of biological macromolecules

    2023  Band 254, Heft Pt 2, Seite(n) 127573

    Abstract: Crowded environments inside cells and biological fluids greatly affect protein stability and activity. PDC-109, a polydisperse oligomeric protein of the bovine seminal plasma selectively binds choline phospholipids on the sperm cell surface and causes ... ...

    Abstract Crowded environments inside cells and biological fluids greatly affect protein stability and activity. PDC-109, a polydisperse oligomeric protein of the bovine seminal plasma selectively binds choline phospholipids on the sperm cell surface and causes membrane destabilization and lipid efflux, leading to acrosome reaction. PDC-109 also exhibits chaperone-like activity (CLA) and protects client proteins against various kinds of stress, such as high temperature and low pH. In the present work, we have investigated the effect of molecular crowding on these two different activities of PDC-109 employing Dextran 70 (D70) - a widely used polymeric dextran - as the crowding agent. The results obtained show that presence of D70 markedly increases membrane destabilization by PDC-109. Isothermal titration calorimetric studies revealed that under crowded condition the binding affinity of PDC-109 for choline phospholipids increases approximately 3-fold, which could in turn facilitate membrane destabilization. In contrast, under identical conditions, its CLA was reduced significantly. The decreased CLA could be correlated to reduced surface hydrophobicity, which was due to stabilization of the protein oligomers. These results establish that molecular crowding exhibits contrasting effects on two different functional activities of PDC-109 and highlight the importance of microenvironment of proteins in modulating their functional activities.
    Mesh-Begriff(e) Humans ; Male ; Cattle ; Animals ; Seminal Plasma Proteins/metabolism ; Semen/metabolism ; Seminal Vesicle Secretory Proteins/analysis ; Seminal Vesicle Secretory Proteins/chemistry ; Seminal Vesicle Secretory Proteins/metabolism ; Spermatozoa/metabolism ; Phospholipids/metabolism ; Choline/analysis
    Chemische Substanzen Seminal Plasma Proteins ; Seminal Vesicle Secretory Proteins ; Phospholipids ; Choline (N91BDP6H0X)
    Sprache Englisch
    Erscheinungsdatum 2023-11-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127573
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  5. Artikel ; Online: Contributions and Limitations of Mitochondria-Targeted and Non-Targeted Antioxidants in the Treatment of Parkinsonism: an Updated Review.

    Banerjee, Priyajit / Saha, Ishita / Sarkar, Diptendu / Maiti, Arpan Kumar

    Neurotoxicity research

    2022  Band 40, Heft 3, Seite(n) 847–873

    Abstract: As conventional therapeutics can only treat the symptoms of Parkinson's disease (PD), major focus of research in recent times is to slow down or prevent the progression of neuronal degeneration in PD. Non-targeted antioxidants have been an integral part ... ...

    Abstract As conventional therapeutics can only treat the symptoms of Parkinson's disease (PD), major focus of research in recent times is to slow down or prevent the progression of neuronal degeneration in PD. Non-targeted antioxidants have been an integral part of the conventional therapeutics regimen; however, their importance have lessened over time because of their controversial outcomes in clinical PD trials. Inability to permeate and localize within the mitochondria remains the main drawback on the part of non-targeted antioxidants inspite of possessing free radical scavenging properties. In contrast, mitochondrial-targeted antioxidants (MTAs), a special class of compounds have emerged having high advantages over non-targeted antioxidants by virtue of efficient pharmacokinetics and better absorption rate with capability to localize many fold inside the mitochondrial matrix. Preclinical experimentations indicate that MTAs have the potential to act as better alternatives compared to conventional non-targeted antioxidants in treating PD; however, sufficient clinical trials have not been conducted to investigate the efficacies of MTAs in treating PD. Controversial clinical outcomes on the part of non-targeted antioxidants and lack of clinical trials involving MTAs have made it difficult to go ahead with a direct comparison and in turn have slowed down the progress of development of safer and better alternate strategies in treating PD. This review provides an insight on the roles MTAs and non-targeted antioxidants have played in the treatment of PD till date in preclinical and clinical settings and discusses about the limitations of mitochondria-targeted and non-targeted antioxidants that can be resolved for developing effective strategies in treating Parkinsonism.
    Mesh-Begriff(e) Antioxidants/therapeutic use ; Humans ; Mitochondria/physiology ; Parkinson Disease/drug therapy ; Parkinsonian Disorders/drug therapy
    Chemische Substanzen Antioxidants
    Sprache Englisch
    Erscheinungsdatum 2022-04-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2036826-4
    ISSN 1476-3524 ; 1029-8428
    ISSN (online) 1476-3524
    ISSN 1029-8428
    DOI 10.1007/s12640-022-00501-x
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  6. Artikel ; Online: Fabrication and Therapeutic Process of a Green Silver-Nanoparticle-Embedded Mucilage Microsphere for Pathogenic-Bacteria-Infected Second-Degree Burn and Excision Wounds.

    Saha, Ishita / Ghosh, Sourav / Mondal, Arunima / Roy, Shubham / Basu, Tarakdas / Sengupta, Arunima / Das, Deepak / Karmakar, Parimal

    ACS applied bio materials

    2024  Band 7, Heft 4, Seite(n) 2554–2568

    Abstract: Multidrug-resistant bacteria are a serious problem in biomedical applications that decrease the wound healing process and increase the mortality rate. Therefore, in this study, we have prepared a green-synthesized silver-nanoparticle-encapsulated ... ...

    Abstract Multidrug-resistant bacteria are a serious problem in biomedical applications that decrease the wound healing process and increase the mortality rate. Therefore, in this study, we have prepared a green-synthesized silver-nanoparticle-encapsulated mucilage microsphere (HMMS@GSNP) from
    Mesh-Begriff(e) Male ; Mice ; Animals ; Silver ; Methicillin-Resistant Staphylococcus aureus ; Microspheres ; Burns/drug therapy ; Nanoparticles
    Chemische Substanzen colloidal silver ; Silver (3M4G523W1G)
    Sprache Englisch
    Erscheinungsdatum 2024-04-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.4c00177
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  7. Artikel ; Online: 10-(6-Plastoquinonyl) decyltriphenylphosphonium imparts anti-colitogenic protection through recovery of mitochondrial dysfunction in ulcerated murine colon: Implications in ulcerative colitis.

    Ghosh, Shashwati / Spoorthi, B C / Banerjee, Priyajit / Saha, Ishita / Dua, Tarun Kumar / Sahu, Ranabir / Maiti, Arpan Kumar

    Life sciences

    2024  Band 348, Seite(n) 122700

    Abstract: Aims: To elucidate the impact of 10-(6-plastoquinonyl) decyltriphenylphosphonium (SkQ1) as an anti-colitogenic agent for maintenance of colon epithelial tract in ulcerated mice through recovery of mitochondrial dysfunction and mitochondrial stress by ... ...

    Abstract Aims: To elucidate the impact of 10-(6-plastoquinonyl) decyltriphenylphosphonium (SkQ1) as an anti-colitogenic agent for maintenance of colon epithelial tract in ulcerated mice through recovery of mitochondrial dysfunction and mitochondrial stress by virtue of its free radical scavenging properties.
    Main methods: DSS induced ulcerated BALB/c mice were treated with SkQ1 for 14 days @ 30 nmol/kg/body wt./day/mice. Post-treatment, isolated colonic mitochondria were utilized for spectrophotometric and spectrofluorometric biochemical analysis of various mitochondrial functional variables including individual mitochondrial respiratory enzyme complexes. Confocal microscopy was utilized for measuring mitochondrial membrane potential in vivo. ELISA technique was adapted for measuring colonic nitrite and 3-nitrotyrosine (3-NT) content. Finally in vitro cell line study was carried out to substantiate in vivo findings and elucidate the involvement of free radicals in UC using antioxidant/free radical scavenging regimen.
    Key findings: Treatment with SkQ1 in vivo reduced histopathological severity of colitis, induced recovery of mitochondrial respiratory complex activities and associated functional variables, improved oxidative stress indices and normalized mitochondrial cardiolipin content. Importantly, SkQ1 lowered nitrite concentration and 3-nitrotyrosine formation in vivo. In vitro SkQ1 restored mitochondrial functions wherein the efficacy of SkQ1 proved equal or better compared to SOD and DMSO indicating predominant involvement of O
    Significance: SkQ1 can be considered as a potent anti-colitogenic agent by virtue of its free radical scavenging properties in treating UC.
    Sprache Englisch
    Erscheinungsdatum 2024-05-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2024.122700
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  8. Artikel ; Online: Melatonin ameliorates lipopolysaccharide induced brain inflammation through modulation of oxidative status and diminution of cytokine rush in Danio rerio.

    Moniruzzaman, Mahammed / Maiti, Arpan Kumar / Chakraborty, Suman Bhusan / Saha, Ishita / Saha, Nimai Chandra

    Environmental toxicology and pharmacology

    2022  Band 96, Seite(n) 103983

    Abstract: Lipopolysaccharide (LPS) is known to induce inflammation and immunonomodulation in a piscine model of Danio rerio. Present study aimed to explore the ability of melatonin in attenuating LPS-induced oxidative damages using this model. In LPS-exposed fish, ... ...

    Abstract Lipopolysaccharide (LPS) is known to induce inflammation and immunonomodulation in a piscine model of Danio rerio. Present study aimed to explore the ability of melatonin in attenuating LPS-induced oxidative damages using this model. In LPS-exposed fish, activation of stress marker MDA was observed in brain with corresponding augmentation of multiple pro-inflammatory cytokines (IL1β, IL6, IL10 and TNFα). In addition, it also showed marked increase in the levels of heat shock factor (HSF) and heat shock proteins (HSPs) in association with transcription factors (NF-kB and NRF2) and mitogen-activated protein kinases (MAPKs). The changes in the levels of these mediators are highly correlated with the induction of pro-inflammatory cytokines. In melatonin-treated fishes, significant amelioration of oxidative stress was observed with reduced levels of MDA and pro-inflammatory cytokines. Melatonin also modulated expression of HSPs that facilitated the brain to overcome inflammation-induced stress by directly initiating NFkB/NRF2 translocation. In summary, melatonin effectively functions to reduce stress induced inflammatory signalling through modulation of oxidative stress and protects the brain from the neuropathological insult.
    Mesh-Begriff(e) Animals ; Lipopolysaccharides/toxicity ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Cytokines/metabolism ; NF-E2-Related Factor 2/metabolism ; Zebrafish/metabolism ; Oxidative Stress ; NF-kappa B/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/pathology ; Encephalitis
    Chemische Substanzen Lipopolysaccharides ; Melatonin (JL5DK93RCL) ; Cytokines ; NF-E2-Related Factor 2 ; NF-kappa B
    Sprache Englisch
    Erscheinungsdatum 2022-09-29
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2022.103983
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  9. Artikel ; Online: In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India.

    Ganai, Indranil / Saha, Ishita / Banerjee, Priyajit / Laha, Arghya / Sultana, Saheen / Sultana, Nasima / Biswas, Himani / Moitra, Saibal / Podder, Sanjoy

    Frontiers in immunology

    2023  Band 14, Seite(n) 1089514

    Abstract: Introduction: Prevalence of asthma is increasing steadily among general population in developing countries over past two decades. One of the causative agents of broncho-constriction in asthma is thromboxane A2 receptor (TBXA2R). However few studies of ... ...

    Abstract Introduction: Prevalence of asthma is increasing steadily among general population in developing countries over past two decades. One of the causative agents of broncho-constriction in asthma is thromboxane A2 receptor (TBXA2R). However few studies of TBXA2R polymorphism were performed so far. The present study aimed to assess potential association of TBXA2R rs34377097 polymorphism causing missense substitution of Arginine to Leucine (R60L) among 482 patients diagnosed with pollen-induced asthma and 122 control participants from West Bengal, India. Also we performed in-silico analysis of mutated TBXA2R protein (R60L) using homology modeling.
    Methods: Clinical parameters like Forced expiratory volume in 1 second (FEV
    Results: Genotype frequencies differed significantly between the study groups (P=0.03). There was no significant deviation from Hardy-Weinberg equilibrium in control population (χ2=1.56). Asthmatic patients have significantly higher frequency of rs34377097TT genotype than control subjects (P=0.03). SPT of patients showed maximum sensitivity in
    Discussion: The present in-silico study is the first one to report association of TBXA2R rs34377097 polymorphism in an Indian population. It may be used as prognostic marker of clinical response to asthma in West Bengal and possible target of therapeutics in future.
    Mesh-Begriff(e) Adolescent ; Humans ; Young Adult ; Asthma/genetics ; Asthma/epidemiology ; Genotype ; Pollen ; Polymorphism, Single Nucleotide ; Receptors, Thromboxane A2, Prostaglandin H2/genetics ; Receptors, Thromboxane A2, Prostaglandin H2/metabolism
    Chemische Substanzen Receptors, Thromboxane A2, Prostaglandin H2
    Sprache Englisch
    Erscheinungsdatum 2023-03-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1089514
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Substance P failed to reverse dextran sulfate sodium-induced murine colitis mediated by mitochondrial dysfunction: implications in ulcerative colitis.

    Chandraiah, Spoorthi B / Ghosh, Shashwati / Saha, Ishita / More, Sunil S / Annappa, Gautham S / Maiti, Arpan K

    3 Biotech

    2021  Band 11, Heft 4, Seite(n) 199

    Abstract: As controversy exists about the efficacy of substance P (SP) in treating ulcerative colitis (UC) with no previous study highlighting the impact of SP on mitochondrial dysfunction in this diseased condition, it became logical to perform the present study. ...

    Abstract As controversy exists about the efficacy of substance P (SP) in treating ulcerative colitis (UC) with no previous study highlighting the impact of SP on mitochondrial dysfunction in this diseased condition, it became logical to perform the present study. C57BL/6 J mice were administered with DSS @ 3.5%/gm body weight for 3 cycles of 5 days each followed by i.v. dose of SP @ 5nmole per kg for consecutive 7 days. Histopathological features were noticed in the affected colon along with colonic mitochondrial dysfunction, alterations in mitochondrial stress variables and enhanced colonic cell death. Interestingly, SP failed to reverse colitic features and proved ineffective in inhibiting mitochondrial dysfunction. Unexpectedly SP alone seemed to impart detrimental effects on some of the mitochondrial functions, enhanced lipid peroxidation and increased staining intensities for caspases 3 and 9 in the normal colon. To substantiate in vivo findings and to assess free radical scavenging property of SP, Caco-2 cells were exposed to DSS with or without SP in the presence and absence of specific free radical scavengers and antioxidants. Interestingly, in vitro treatment with SP failed to restore mitochondrial functions and its efficacy proved below par compared to SOD and DMSO indicating involvement of O
    Sprache Englisch
    Erscheinungsdatum 2021-03-29
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-021-02755-2
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