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  1. Buch ; Online: Therapeutic Landscapes in Colorectal Carcinoma

    Scanu, Antonio M / De Miglio, Maria Rosaria

    2023  

    Schlagwörter Medicine ; Oncology ; colorectal cancer ; inflammatory pathways ; NFKB ; RIPK2 ; MSI ; dMMR ; colorectal ; cancer ; immunotherapy ; Romania ; incidence ; PCR ; IHC ; drug development ; targeted therapies ; preclinical candidates ; databases ; cancer therapeutics ; TGF-b ; regorafenib ; colorectal carcinoma ; intratumor heterogeneity ; single-cell next-generation sequencing ; precision medicine ; metastatic colorectal cancer ; BRAF mutation ; triple target therapy ; colorectal cancer screening ; COVID-19 ; SARS-CoV-2 ; colon cancer ; cell line models ; dependencies ; targeted therapy ; signal transduction ; neoadjuvant chemotherapy (NAC) ; locally advanced colon cancer (LACC) ; preoperative treatment ; propensity score matching ; survival ; liver transplantation ; de novo malignancy ; immunosuppression ; uracil-tegafur ; chemotherapy ; adjuvant therapy ; stage IIA ; n/a
    Sprache Englisch
    Umfang 1 electronic resource (142 pages)
    Verlag MDPI - Multidisciplinary Digital Publishing Institute
    Erscheinungsort Basel
    Dokumenttyp Buch ; Online
    Anmerkung English
    HBZ-ID HT030646168
    ISBN 9783036594408 ; 303659440X
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Therapeutic Landscapes in Colorectal Carcinoma.

    Scanu, Antonio Mario / De Miglio, Maria Rosaria

    Medicina (Kaunas, Lithuania)

    2023  Band 59, Heft 5

    Abstract: Colorectal cancer (CRC) is a disease of major public health and socioeconomic concern [ ... ]. ...

    Abstract Colorectal cancer (CRC) is a disease of major public health and socioeconomic concern [...].
    Mesh-Begriff(e) Humans ; Colorectal Neoplasms/therapy ; Colorectal Neoplasms/pathology ; Public Health
    Sprache Englisch
    Erscheinungsdatum 2023-04-23
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59050821
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Current management of incidental gallbladder cancer: A review.

    Feo, Claudio F / Ginesu, Giorgio C / Fancellu, Alessandro / Perra, Teresa / Ninniri, Chiara / Deiana, Giulia / Scanu, Antonio M / Porcu, Alberto

    International journal of surgery (London, England)

    2022  Band 98, Seite(n) 106234

    Abstract: Early-stage gallbladder cancer (GBC) is mostly discovered incidentally by the pathologist after cholecystectomy for a presumed benign disease. It is the most common malignancy of the biliary tract with a variable incidence rate all over the World. The ... ...

    Abstract Early-stage gallbladder cancer (GBC) is mostly discovered incidentally by the pathologist after cholecystectomy for a presumed benign disease. It is the most common malignancy of the biliary tract with a variable incidence rate all over the World. The majority of patients with GBC remain asymptomatic for a long time and diagnosis is usually late when the disease is at an advanced stage. Radical surgery consisting in resection of the gallbladder liver bed and regional lymph nodes seems to be the best treatment option for incidental GBC. However, recurrence rates after salvage surgery are still high and the addition of neoadjuvant/adjuvant chemotherapy may improve outcomes. The aim of the present review is to evaluate current literature for advances in management of incidental GBC, with particular focus on staging techniques and surgical options.
    Mesh-Begriff(e) Cholecystectomy ; Gallbladder Neoplasms/diagnosis ; Gallbladder Neoplasms/epidemiology ; Gallbladder Neoplasms/surgery ; Humans ; Incidental Findings ; Lymph Node Excision ; Neoplasm Staging
    Sprache Englisch
    Erscheinungsdatum 2022-01-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2022.106234
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Harnessing Minimal Residual Disease as a Predictor for Colorectal Cancer: Promising Horizons Amidst Challenges.

    Wen, Xiaofen / Coradduzza, Donatella / Shen, Jiaxin / Scanu, Antonio Mario / Muroni, Maria Rosaria / Massidda, Matteo / Rallo, Vincenzo / Carru, Ciriaco / Angius, Andrea / De Miglio, Maria Rosaria

    Medicina (Kaunas, Lithuania)

    2023  Band 59, Heft 10

    Abstract: Minimal Residual Disease (MRD) detection has emerged as an independent factor in clinical and pathological cancer assessment offering a highly effective method for predicting recurrence in colorectal cancer (CRC). The ongoing research initiatives such as ...

    Abstract Minimal Residual Disease (MRD) detection has emerged as an independent factor in clinical and pathological cancer assessment offering a highly effective method for predicting recurrence in colorectal cancer (CRC). The ongoing research initiatives such as the DYNAMIC and CIRCULATE-Japan studies, have revealed the potential of MRD detection based on circulating tumor DNA (ctDNA) to revolutionize management for CRC patients. MRD detection represents an opportunity for risk stratification, treatment guidance, and early relapse monitoring. Here we overviewed the evolving landscape of MRD technology and its promising applications through the most up-to-date research and reviews, underscoring the transformative potential of this approach. Our primary focus is to provide a point-to-point perspective and address key challenges relating to the adoption of ctDNA-based MRD detection in the clinical setting. By identifying critical areas of interest and hurdles surrounding clinical significance, detection criteria, and potential applications of basic research, this article offers insights into the advancements needed to evaluate the role of ctDNA in CRC MRD detection, contributing to favorable clinical options and improved outcomes in the management of CRC.
    Mesh-Begriff(e) Humans ; Neoplasm, Residual/diagnosis ; Clinical Relevance ; Japan ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Biomarkers, Tumor/genetics
    Chemische Substanzen Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2023-10-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59101886
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: A Portrait of Intratumoral Genomic and Transcriptomic Heterogeneity at Single-Cell Level in Colorectal Cancer.

    Angius, Andrea / Scanu, Antonio Mario / Arru, Caterina / Muroni, Maria Rosaria / Carru, Ciriaco / Porcu, Alberto / Cossu-Rocca, Paolo / De Miglio, Maria Rosaria

    Medicina (Kaunas, Lithuania)

    2021  Band 57, Heft 11

    Abstract: In the study of cancer, omics technologies are supporting the transition from traditional clinical approaches to precision medicine. Intra-tumoral heterogeneity (ITH) is detectable within a single tumor in which cancer cell subpopulations with different ... ...

    Abstract In the study of cancer, omics technologies are supporting the transition from traditional clinical approaches to precision medicine. Intra-tumoral heterogeneity (ITH) is detectable within a single tumor in which cancer cell subpopulations with different genome features coexist in a patient in different tumor areas or may evolve/differ over time. Colorectal carcinoma (CRC) is characterized by heterogeneous features involving genomic, epigenomic, and transcriptomic alterations. The study of ITH is a promising new frontier to lay the foundation towards successful CRC diagnosis and treatment. Genome and transcriptome sequencing together with editing technologies are revolutionizing biomedical research, representing the most promising tools for overcoming unmet clinical and research challenges. Rapid advances in both bulk and single-cell next-generation sequencing (NGS) are identifying primary and metastatic intratumoral genomic and transcriptional heterogeneity. They provide critical insight in the origin and spatiotemporal evolution of genomic clones responsible for early and late therapeutic resistance and relapse. Single-cell technologies can be used to define subpopulations within a known cell type by searching for differential gene expression within the cell population of interest and/or effectively isolating signal from rare cell populations that would not be detectable by other methods. Each single-cell sequencing analysis is driven by clustering of cells based on their differentially expressed genes. Genes that drive clustering can be used as unique markers for a specific cell population. In this review we analyzed, starting from published data, the possible achievement of a transition from clinical CRC research to precision medicine with an emphasis on new single-cell based techniques; at the same time, we focused on all approaches and issues related to this promising technology. This transition might enable noninvasive screening for early diagnosis, individualized prediction of therapeutic response, and discovery of additional novel drug targets.
    Mesh-Begriff(e) Colorectal Neoplasms/genetics ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Precision Medicine ; Transcriptome/genetics
    Sprache Englisch
    Erscheinungsdatum 2021-11-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57111257
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Lipoprotein(a): Looking ahead.

    Scanu, Angelo M

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2005  Band 15, Heft 5, Seite(n) 331–333

    Mesh-Begriff(e) Apolipoprotein B-100 ; Apolipoproteins A/blood ; Apolipoproteins A/chemistry ; Apolipoproteins B/chemistry ; Cardiovascular Diseases ; Humans ; Lipoprotein(a)/blood ; Lipoprotein(a)/chemistry ; Lipoprotein(a)/genetics ; Lipoproteins, LDL/blood ; Lipoproteins, LDL/chemistry
    Chemische Substanzen Apolipoprotein B-100 ; Apolipoproteins A ; Apolipoproteins B ; Lipoprotein(a) ; Lipoproteins, LDL
    Sprache Englisch
    Erscheinungsdatum 2005-10
    Erscheinungsland Netherlands
    Dokumenttyp Editorial
    ZDB-ID 1067704-5
    ISSN 0939-4753
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2005.07.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  7. Artikel: Metaproteomic Profile of the Colonic Luminal Microbiota From Patients With Colon Cancer.

    Tanca, Alessandro / Abbondio, Marcello / Fiorito, Giovanni / Pira, Giovanna / Sau, Rosangela / Manca, Alessandra / Muroni, Maria Rosaria / Porcu, Alberto / Scanu, Antonio Mario / Cossu-Rocca, Paolo / De Miglio, Maria Rosaria / Uzzau, Sergio

    Frontiers in microbiology

    2022  Band 13, Seite(n) 869523

    Abstract: Recent studies have provided evidence of interactions among the gut microbiota (GM), local host immune cells, and intestinal tissues in colon carcinogenesis. However, little is known regarding the functions exerted by the GM in colon cancer (CC), ... ...

    Abstract Recent studies have provided evidence of interactions among the gut microbiota (GM), local host immune cells, and intestinal tissues in colon carcinogenesis. However, little is known regarding the functions exerted by the GM in colon cancer (CC), particularly with respect to tumor clinical classification and lymphocyte infiltration. In addition, stool, usually employed as a proxy of the GM, cannot fully represent the original complexity of CC microenvironment. Here, we present a pilot study aimed at characterizing the metaproteome of CC-associated colonic luminal contents and identifying its possible associations with CC clinicopathological features. Colonic luminal contents were collected from 24 CC tissue specimens immediately after surgery. Samples were analyzed by shotgun metaproteomics. Almost 30,000 microbial peptides were quantified in the samples, enabling the achievement of the taxonomic and functional profile of the tumor-associated colonic luminal metaproteome. Upon sample aggregation based on tumor stage, grade, or tumor-infiltrating lymphocytes (TILs), peptide sets enabling discrimination of sample groups were identified through discriminant analysis (DA). As a result,
    Sprache Englisch
    Erscheinungsdatum 2022-04-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.869523
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Inflammatory Indexes as Predictive Biomarkers of Postoperative Complications in Oncological Thoracic Surgery.

    Ginesu, Giorgio Carlo / Paliogiannis, Panagiotis / Feo, Claudio F / Cossu, Maria Laura / Scanu, Antonio Mario / Fancellu, Alessandro / Fois, Alessandro Giuseppe / Zinellu, Angelo / Perra, Teresa / Veneroni, Simone / Porcu, Alberto

    Current oncology (Toronto, Ont.)

    2022  Band 29, Heft 5, Seite(n) 3425–3432

    Abstract: The role of inflammatory responses in predicting outcomes in oncological thoracic surgery is still unclear. The aim of this study was to evaluate a series of blood count inflammation indexes as predicting factors for postoperative complications. We ... ...

    Abstract The role of inflammatory responses in predicting outcomes in oncological thoracic surgery is still unclear. The aim of this study was to evaluate a series of blood count inflammation indexes as predicting factors for postoperative complications. We retrospectively studied 249 patients undergoing elective thoracic surgery in our institution between 2008 and 2020. A total of 184 patients underwent open surgery, and 65 underwent VATS. The neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte (PLR) ratios, Systemic Inflammation Response Index (SIRI) were calculated preoperatively and on the first and fourth postoperative days, as well as a new derivative index, the Aggregate Inflammation Systemic Index (AISI). Univariate correlations evidenced a statistically significant association between the NLR at the fourth postoperative day and the occurrence of surgical complications in the global cohort (rho = 0.15,
    Mesh-Begriff(e) Biomarkers ; Humans ; Inflammation ; Postoperative Complications/etiology ; Prospective Studies ; Retrospective Studies ; Thoracic Surgery
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2022-05-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29050276
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report.

    Feo, Claudio F / Veneroni, Simone / Santoru, Antonio / Cossu, Maria Laura / Scanu, Antonio M / Ginesu, Giorgio C / Porcu, Alberto

    International journal of surgery case reports

    2020  Band 78, Seite(n) 99–102

    Abstract: Introduction: Perianal mucinous adenocarcinoma is rarely encountered in the setting of anal neoplasms. The rarity of the disease and the paucity of publications on this topic are responsible for a lack of diagnostic and therapeutic guidelines.: ... ...

    Abstract Introduction: Perianal mucinous adenocarcinoma is rarely encountered in the setting of anal neoplasms. The rarity of the disease and the paucity of publications on this topic are responsible for a lack of diagnostic and therapeutic guidelines.
    Presentation of case: An 80-year-old man with mucinous adenocarcinoma of the anal canal associated with dysplastic polyps of the colon was treated by multiple endoscopic polypectomies and abdomino-perineal resection of the rectum. We discuss the management of this rare case from the diagnosis up to one-year follow-up.
    Discussion: Perianal mucinous adenocarcinoma is a very rare entity frequently combined with chronic fistulas. Inflammatory symptoms may mislead its diagnosis, which is often delayed. The unique association between perianal mucinous adenocarcinoma and dysplastic polyps of the colon, that we have reported, may suggest a secondary etiology. High clinical suspicion is important for early and correct diagnosis, which should be based on endoanal ultrasound and/or magnetic resonance imaging followed by deep tissue biopsies.
    Conclusion: We stress the importance of accumulating such cases in the literature. The understanding of the etiopathogenic mechanisms may lead to the development of novel diagnostic and therapeutic protocols.
    Sprache Englisch
    Erscheinungsdatum 2020-12-05
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.12.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Lp(a) lipoprotein--coping with heterogeneity.

    Scanu, Angelo M

    The New England journal of medicine

    2003  Band 349, Heft 22, Seite(n) 2089–2090

    Mesh-Begriff(e) Cardiovascular Diseases/blood ; Genetic Heterogeneity ; Humans ; Lipoprotein(a)/blood ; Lipoprotein(a)/chemistry ; Lipoprotein(a)/genetics ; Lipoproteins, LDL/blood ; Lipoproteins, LDL/chemistry ; Risk Factors
    Chemische Substanzen Lipoprotein(a) ; Lipoproteins, LDL
    Sprache Englisch
    Erscheinungsdatum 2003-11-27
    Erscheinungsland United States
    Dokumenttyp Comment ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp038128
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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