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  1. Artikel ; Online: Cultivating curiosity about our patients can make all the difference to their care.

    Smith, Louise

    BMJ (Clinical research ed.)

    2024  Band 384, Seite(n) q129

    Sprache Englisch
    Erscheinungsdatum 2024-01-17
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.q129
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Integrating the Physical Environment Within a Population Neuroscience Perspective.

    Smith, Lindsey

    Current topics in behavioral neurosciences

    2024  

    Abstract: Population neuroscience recognises the role of the environment in shaping brain, behaviour, and mental health. An overview of current evidence from neuroscientific and epidemiological studies highlights the protective effects of nature on cognitive ... ...

    Abstract Population neuroscience recognises the role of the environment in shaping brain, behaviour, and mental health. An overview of current evidence from neuroscientific and epidemiological studies highlights the protective effects of nature on cognitive function and stress reduction, the detrimental effects of urban living on mental health, and emerging concerns relating to extreme weather events and eco-anxiety. Despite the growing body of evidence in this area, knowledge gaps remain due to inconsistent measures of exposure and a reliance on small samples. In this chapter, attention is given to the physical environment and population-level studies as a necessary starting point for exploring the long-term impacts of environmental exposures on mental health, and for informing future research that may capture immediate emotional and neural responses to the environment. Key data sources, including remote sensing imagery, administrative, sensor, and social media data, are outlined. Appropriate measures of exposure are advocated for, recognising the value of area-level measures for estimating exposure over large study samples and spatial and temporal scales. Although integrating data from multiple sources requires consideration for data quality and completeness, deep learning and the increasing availability of high-resolution data present opportunities to build a more complete picture of physical environments. Advances in leveraging detailed locational data are discussed as a subsequent approach for building upon initial observations from population studies and improving understanding of the mechanisms underlying behaviour and human-environment interactions.
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2024_477
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Should Patients Be Required to Receive COVID Vaccine to Be Listed for Kidney Transplant?: PRO.

    Smith, LaMorgan

    Kidney360

    2024  Band 5, Heft 2, Seite(n) 175–176

    Mesh-Begriff(e) Humans ; Kidney Transplantation ; COVID-19 Vaccines ; COVID-19/prevention & control ; Kidney Failure, Chronic ; Vaccines
    Chemische Substanzen COVID-19 Vaccines ; Vaccines
    Sprache Englisch
    Erscheinungsdatum 2024-01-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000324
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The marine sponge, Hymeniacidon sinapium, displays allorecognition of siblings during post-larval settling and metamorphosis to juveniles.

    Smith, L Courtney

    Developmental and comparative immunology

    2024  Band 157, Seite(n) 105179

    Abstract: Marine sponges, including the crumb of bread sponge, Hymeniacidon sinapium, display allorejection responses to contact with conspecifics in both experimental and natural settings. These responses have been used to infer immunocompetence in a variety of ... ...

    Abstract Marine sponges, including the crumb of bread sponge, Hymeniacidon sinapium, display allorejection responses to contact with conspecifics in both experimental and natural settings. These responses have been used to infer immunocompetence in a variety of marine invertebrates. However, larvae and juveniles from several marine sponge species fuse and form chimeras. Some of these chimeras persist, whereas others eventually break down, revealing a period of allogeneic non-responsiveness that varies depending on the species. Alternatively, for H. sinapium, most pairs of sibling post-larvae and juveniles that settle in contact initiate immediate allorecognition and show the same morphological response progression as the adults. This indicates that allorecognition and response occurs during early metamorphosis. Results from H. sinapium and other sponge species, in addition to annotations of sponge genomes, suggest that allorecognition and immunocompetence in sponges are mediated by distinct systems and may become functional at different times during or after metamorphosis for different species. Consequently, allorecognition may not be a good proxy for the onset of immunocompetence.
    Sprache Englisch
    Erscheinungsdatum 2024-04-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2024.105179
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  5. Artikel ; Online: My Induction Into Anesthesiology: Where Words No Longer Work.

    Smith, L Daniela

    Anesthesia and analgesia

    2024  Band 138, Heft 6, Seite(n) 1349

    Mesh-Begriff(e) Humans ; Anesthesiology/methods ; Anesthesiologists
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006629
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  6. Artikel ; Online: Space station and spacecraft environmental conditions and human mental health: Specific recommendations and guidelines.

    Smith, Logan

    Life sciences in space research

    2023  Band 40, Seite(n) 126–134

    Abstract: The way that a given environment may influence human mental health is widely established, with decades of research linking anxiety, depression, stress, productivity, and general mood with all facets of a given environment, including noise levels, ... ...

    Abstract The way that a given environment may influence human mental health is widely established, with decades of research linking anxiety, depression, stress, productivity, and general mood with all facets of a given environment, including noise levels, lighting, air quality, and other factors. The environmental conditions of a space habitat have far reaching consequences for human mental health and should be carefully managed. This manuscript serves to briefly review what is known about the main components of a space habitat (e.g., noise levels, lighting, air quality, privacy, plant life, etc.), and provide specific and clear recommendations for mission planners and space habitat designers. Where appropriate, opportunities for future research are highlighted.
    Mesh-Begriff(e) Humans ; Spacecraft ; Space Flight ; Mental Health
    Sprache Englisch
    Erscheinungsdatum 2023-10-11
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ISSN 2214-5532
    ISSN (online) 2214-5532
    DOI 10.1016/j.lssr.2023.10.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Relationship Between Gene Expression Networks and Muscle Contractile Physiology Differences in Anolis Lizards.

    Smith, Luke

    South Dakota medicine : the journal of the South Dakota State Medical Association

    2023  Band 76, Heft 9, Seite(n) 404

    Abstract: Introduction: Muscles facilitate most animal behavior, from eating to fleeing. However, to generate the variation in behavior necessary for survival, different muscles must perform differently. For instance, sprinting requires multiple rapid muscle ... ...

    Abstract Introduction: Muscles facilitate most animal behavior, from eating to fleeing. However, to generate the variation in behavior necessary for survival, different muscles must perform differently. For instance, sprinting requires multiple rapid muscle contractions, whereas biting may require fewer contractions but greater force.
    Methods: Here, a transcriptomic approach was utilized to identify genes associated with variation in muscle contractile physiology among different muscles from the same individual. Differential gene expression was measured between a leg and jaw muscle of Anolis lizards (A. chlorocyanus, A. cybotes, A. osa, A. sagrei) known to differ in muscle contractile physiology and performance. For each individual, one muscle was used to measure muscle contractile physiology, including Vmax (the muscle contraction velocity at zero force), V40 (the muscle contraction velocity at 40% force), power ratio (a measure of the trade-off between force and velocity), and twitch time (the amount of time it takes to create and dissipate tension at 50% force). The contralateral muscle was used to extract RNA for transcriptomic sequencing. Weighted Gene Co-Expression Analysis (WGCNA) was performed to cluster differentially expressed genes into groups, or modules with color designations, based on an eigengene. Modules were correlated to physiologic metrics and analyzed for function with gene ontology (GO term) analysis.
    Results: Using the transcriptomic data, clear clustering of muscle type was found indicating there were no specific differences among the four species. Several contractile metrics were significantly different between the jaw and leg: twitch time, V40, and power ratio. Expression of genes clustered in GO terms related to muscle contraction and extracellular matrix was negatively correlated with slower twitch times but positively correlated to power ratio and V40. Conversely, genes related to the GO terms related to aerobic respiration were downregulated in muscles with higher power ratio and V40 and over-expressed with slower twitch times.
    Conclusions: Determining the molecular mechanisms that underlie variation in muscle contractile physiology can begin to explain how organisms are able to optimize behavior under variable conditions. Key areas of difference between gene expression of the jaw and leg included muscle contraction, energy synthesis, and extracellular structures. Modules relating to aerobic respiration are strongly correlated with slower twitch time likely due to slower utilization of ATP. Modules relating to muscle contraction and extracellular structure are negatively correlated with slower twitch time and positively correlated with V40 and power ratio indicating the increased need for structural components to increase and transmit force for greater power.
    Mesh-Begriff(e) Animals ; Lizards/genetics ; Muscle Contraction/genetics ; Muscles ; Gene Expression
    Sprache Englisch
    Erscheinungsdatum 2023-09-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2278073-7
    ISSN 0038-3317
    ISSN 0038-3317
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Regulation and the scope of practice of the RNA role.

    Smith, Laura

    British journal of nursing (Mark Allen Publishing)

    2023  Band 32, Heft 8, Seite(n) 368–370

    Abstract: The nursing associate role was introduced in in 2017, and is now registered with the Nursing and Midwifery Council. This article looks at the importance of understanding the registered nursing associate (RNA) scope of practice. In some areas, the roles ... ...

    Abstract The nursing associate role was introduced in in 2017, and is now registered with the Nursing and Midwifery Council. This article looks at the importance of understanding the registered nursing associate (RNA) scope of practice. In some areas, the roles of the RNA and registered nurse have become interchangeable with detriment to patient safety. The author explores the differences between the role of a registered nurse and an RNA, the training completed by RNAs and ways in which they can free the time of the registered nurse to provide more complex nursing care. As a registrant, nursing associates are accountable for their own practice and responsible for accepting tasks, as well as delegating tasks. Again, it is important that RNAs themselves and members of the multidisciplinary team understand what this means in practice and for maintaining patient safety.
    Mesh-Begriff(e) Humans ; Scope of Practice ; Nursing Care ; Nurse's Role
    Sprache Englisch
    Erscheinungsdatum 2023-04-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2023.32.8.368
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  9. Artikel: The saga of James Lucett and the process for curing insanity, Part 2 (1814-38): 'Insanity cured'.

    Smith, Leonard

    History of psychiatry

    2023  , Seite(n) 957154X231211727

    Abstract: Following the collapse of the Delahoyde and Lucett joint enterprise, James Lucett resumed practice on his own account. He continued to implement his 'process', promoting it as a unique cure for intractable cases of insanity. For two decades he pursued ... ...

    Abstract Following the collapse of the Delahoyde and Lucett joint enterprise, James Lucett resumed practice on his own account. He continued to implement his 'process', promoting it as a unique cure for intractable cases of insanity. For two decades he pursued his activities, with varying success, at different locations in the London area. He maintained his public profile by extensive advertising, letters to newspapers and published pamphlets, extolling his unique 'discovery' and recounting claims of successful cures achieved. Accusations of quackery persisted along with other hostile criticism, particularly from medical men, which Lucett strongly challenged. Periodically he faced more serious difficulties due to legal infractions or financial hardships, but somehow Lucett survived most of these and persevered with his endeavours.
    Sprache Englisch
    Erscheinungsdatum 2023-12-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1028145-9
    ISSN 1740-2360 ; 0957-154X
    ISSN (online) 1740-2360
    ISSN 0957-154X
    DOI 10.1177/0957154X231211727
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  10. Artikel: The saga of James Lucett and the process for curing insanity, Part 1 (1811-14): The rise and fall of Delahoyde and Lucett.

    Smith, Leonard

    History of psychiatry

    2023  Band 35, Heft 2, Seite(n) 125–140

    Abstract: James Lucett, a London clerk, claimed possession of a secret remedy for curing chronic insanity. In 1813, he and the Irish surgeon Charles Delahoyde secured royal and aristocratic patronage to implement their 'process' and opened a private asylum. They ... ...

    Abstract James Lucett, a London clerk, claimed possession of a secret remedy for curing chronic insanity. In 1813, he and the Irish surgeon Charles Delahoyde secured royal and aristocratic patronage to implement their 'process' and opened a private asylum. They aroused great public interest after apparently remarkable results with hitherto intractable patients from Bethlem and Hoxton. Delahoyde and Lucett attained brief celebrity, but within a year it was evident that the dramatic recoveries were only temporary. Their venture collapsed in disarray and bankruptcy, and the episode was soon largely forgotten. Delahoyde fled to Ireland, but Lucett managed to re-establish himself in practice. This article narrates the origins, operation and failure of the enterprise. A second article will consider Lucett's subsequent career.
    Mesh-Begriff(e) History, 19th Century ; Humans ; Hospitals, Psychiatric/history ; Ireland
    Sprache Englisch
    Erscheinungsdatum 2023-11-08
    Erscheinungsland England
    Dokumenttyp Historical Article ; Journal Article ; Biography
    ZDB-ID 1028145-9
    ISSN 1740-2360 ; 0957-154X
    ISSN (online) 1740-2360
    ISSN 0957-154X
    DOI 10.1177/0957154X231199352
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